Zobrazeno 1 - 10
of 20
pro vyhledávání: '"P. I. Lorenzo"'
Autor:
N. Cobo-Vuilleumier, P. I. Lorenzo, E. Martin Vazquez, L. López Noriega, R. Nano, L. Piemonti, F. Martín, B. R. Gauthier
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The intricate etiology of type 1 diabetes mellitus (T1D), characterized by harmful interactions between the immune system and insulin-producing beta cells, has hindered the development of effective therapies including human islet transplantation, whi
Externí odkaz:
https://doaj.org/article/eeaffeea84374d9e83d3ee9e209b180b
Autor:
Eugenia Martin Vázquez, Nadia Cobo-Vuilleumier, Raquel Araujo Legido, Sandra Marín-Cañas, Emanuele Nola, Akaitz Dorronsoro, Lucia López Bermudo, Alejandra Crespo, Silvana Y. Romero-Zerbo, Maria García-Fernández, Alejandro Martin Montalvo, Anabel Rojas, Valentine Comaills, Francisco J. Bérmudez-Silva, Maureen Gannon, Franz Martin, Decio Eizirik, Petra I. Lorenzo, Benoit R. Gauthier
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104345- (2022)
Summary: LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse models of Type 1 Diabetes Mellitus. Islet transcriptome profiling re
Externí odkaz:
https://doaj.org/article/8058666987f74aa8a44031e045ebfaf8
Autor:
Alejandro I. Lorenzo-Pouso, Mercedes Gallas-Torreira, Mario Pérez-Sayáns, Cintia M. Chamorro-Petronacci, Oscar Alvarez-Calderon, Bahi Takkouche, Claudiu T. Supuran, Abel García-García
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1258-1266 (2020)
Carbonic anhydrase IX (CAIX) is a hypoxia-related protein considered as a predictor for oral squamous cell carcinoma (OSCC) biological behaviour. Nevertheless, this prognostic value is still yet to be validated. We aim to quantify prognostic signific
Externí odkaz:
https://doaj.org/article/4596948d64114b9cabc8690e27eb751d
Autor:
Alejandro I. Lorenzo-Pouso, Alba Pérez-Jardón, Vito Carlo Alberto Caponio, Francesca Spirito, Cintia M. Chamorro-Petronacci, Óscar Álvarez-Calderón-Iglesias, Pilar Gándara-Vila, Lorenzo Lo Muzio, Mario Pérez-Sayáns
Publikováno v:
Journal of Fungi, Vol 8, Iss 10, p 1093 (2022)
Chronic hyperplastic candidiasis (CHC) is a prototypical oral lesion caused by chronic Candida infection. A major controversy surrounding CHC is whether this oral lesion owns malignant transformation (MT) potential. The aim of the present study was t
Externí odkaz:
https://doaj.org/article/c7959d59fa6d45de9f8acca0598391b1
Autor:
Elena Padin-Iruegas, Cintia M. Chamorro-Petronacci, Iria Sines-Cajade, Alejandro I. Lorenzo-Pouso, Andrés Blanco-Carrión, Alba Pérez-Jardón, Pilar Gándara-Vila, Mario Pérez-Sayans
Publikováno v:
Medicina, Vol 58, Iss 7, p 878 (2022)
Background and Objectives: MGMT methylation is a well-described biomarker in several solid tumors and MLH1 seems to occur in the initial stages of oral carcinogenesis. The aims of this study were to evaluate MHL1 and MGMT methylation levels in oral s
Externí odkaz:
https://doaj.org/article/ba8502c4680941cd9828e46d62020d8d
Autor:
Nadia Cobo-Vuilleumier, Petra I. Lorenzo, Noelia García Rodríguez, Irene de Gracia Herrera Gómez, Esther Fuente-Martin, Livia López-Noriega, José Manuel Mellado-Gil, Silvana-Yanina Romero-Zerbo, Mathurin Baquié, Christian Claude Lachaud, Katja Stifter, German Perdomo, Marco Bugliani, Vincenzo De Tata, Domenico Bosco, Geraldine Parnaud, David Pozo, Abdelkrim Hmadcha, Javier P. Florido, Miguel G. Toscano, Peter de Haan, Kristina Schoonjans, Luis Sánchez Palazón, Piero Marchetti, Reinhold Schirmbeck, Alejandro Martín-Montalvo, Paolo Meda, Bernat Soria, Francisco-Javier Bermúdez-Silva, Luc St-Onge, Benoit R. Gauthier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Type 1 diabetes mellitus (T1DM) is characterized by beta cell loss because of an autoimmune attack. Here the authors show that an agonist for LRH-1/NR5A2, a nuclear receptor known to be protective against beta cell apoptosis, inhibits immune-mediated
Externí odkaz:
https://doaj.org/article/fbb9d971aff1451c95b83f3e8763290c
Publikováno v:
Cell Stress, Vol 2, Iss 6, Pp 141-143 (2018)
Type 1 diabetes mellitus (T1DM) is defined as an autoimmune disease that targets the selective destruction of islet insulin-producing beta cells by infiltrating immune cells (insulitis). As a result, the organism is no longer able to produce insulin
Externí odkaz:
https://doaj.org/article/f75c5751d6db4241a1f0cba0b1e4f1df
Autor:
Xiang Y. Kong, Cecilie Kasi Nesset, Markus Damme, Else-Marit Løberg, Torben Lübke, Jan Mæhlen, Kristin B. Andersson, Petra I. Lorenzo, Norbert Roos, G. Hege Thoresen, Arild C. Rustan, Eili T. Kase, Winnie Eskild
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 3, Pp 351-362 (2014)
Human kidney predominant protein, NCU-G1, is a highly conserved protein with an unknown biological function. Initially described as a nuclear protein, it was later shown to be a bona fide lysosomal integral membrane protein. To gain insight into the
Externí odkaz:
https://doaj.org/article/118cd37476824946b0852ead9ad9bb7b
Publikováno v:
Trabajos de Prehistoria, Vol 62, Iss 1, Pp 65-83 (2005)
En este articulo se pasa revista, de forma resumida, a 20 años de excavaciones en el abrigo del Filador y se dan a conocer los resultados más importantes (sedimentología, fauna, polen, industria, dataciones, etc..), obtenidos con la aplicación de
Externí odkaz:
https://doaj.org/article/0db23251bb4f46edb1e927582d976f64
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