Výsledky vyhledávání - "P. Holtappels"

Akademický článek

Rapid Down‐Slope Transport of Fresh Dissolved Organic Matter to the Deep Ocean in the Eastern North Atlantic

Autor: Bingbing Wei, Michael Seidel, Gesine Mollenhauer, Alice Lefebvre, Elda Miramontes, Hendrik Grotheer, Marcus Elvert, Jenny Wendt, Thorsten Dittmar, Moritz Holtappels

Publikováno v: Geophysical Research Letters, Vol 51, Iss 21, Pp n/a-n/a (2024)

Abstract Intense convective mixing in the central North Atlantic is a major gateway for dissolved organic matter (DOM) into the deep ocean, sustaining elevated dissolved organic carbon (DOC) concentrations. Rapid down‐slope transport on adjacent Ir

Externí odkaz: https://doaj.org/article/a7c138a94a8140de9b85bd60942de16d

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Akademický článek

Case Report: Dual monoclonal antibody therapy in chronic rhinosinusitis with nasal polyps and severe eosinophilic asthma—a proteome analysis

Autor: Manon Blauwblomme, Philippe Gevaert, Sharon Van Nevel, Sebastian Riemann, Elke Vandewalle, Gabriele Holtappels, Natalie De Ruyck, Lara Derycke, Anne-Sophie Eeckels, Stijn Vanhee, Bart N. Lambrecht, Guy Brusselle, Thibaut Van Zele

Publikováno v: Frontiers in Allergy, Vol 5 (2024)

ContextRecent insights into type 2 inflammation have led to the development of monoclonal antibody therapies for severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). Despite add-on therapy with a monoclonal antibody, some individuals

Externí odkaz: https://doaj.org/article/5788d24459c043d2a013ed0b837983f4

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Akademický článek

Cytomegalovirus inhibitors of programmed cell death restrict antigen cross-presentation in the priming of antiviral CD8 T cells.

Autor: Stefan Ebert, Verena Böhm, Julia K Büttner, Wolfram Brune, Melanie M Brinkmann, Rafaela Holtappels, Matthias J Reddehase, Niels A W Lemmermann

Publikováno v: PLoS Pathogens, Vol 20, Iss 8, p e1012173 (2024)

CD8 T cells are the predominant effector cells of adaptive immunity in preventing cytomegalovirus (CMV) multiple-organ disease caused by cytopathogenic tissue infection. The mechanism by which CMV-specific, naïve CD8 T cells become primed and clonal

Externí odkaz: https://doaj.org/article/1200ce28502447d2809beede76445e04

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Akademický článek

Genomic characterization of Pseudomonas syringae pv. syringae from Callery pear and the efficiency of associated phages in disease protection

Autor: D. Holtappels, S. A. Abelson, S. C. Nouth, G. E. J. Rickus, S. Z. Amare, J. P. Giller, D. Z. Jian, B. Koskella

Publikováno v: Microbiology Spectrum, Vol 12, Iss 3 (2024)

ABSTRACTThe Pseudomonas syringae species complex is a heterogeneous group of plant pathogenic bacteria associated with a wide distribution of plant species. Advances in genomics are revealing the complex evolutionary history of this species complex a

Externí odkaz: https://doaj.org/article/98be9ea5fa6e440d80e6b0c950a9fc66

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Akademický článek

Modulation of cytomegalovirus immune evasion identifies direct antigen presentation as the predominant mode of CD8 T-cell priming during immune reconstitution after hematopoietic cell transplantation

Autor: Rafaela Holtappels, Julia K. Büttner, Kirsten Freitag, Matthias J. Reddehase, Niels A. Lemmermann

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Cytomegalovirus (CMV) infection is the most critical infectious complication in recipients of hematopoietic cell transplantation (HCT) in the period between a therapeutic hematoablative treatment and the hematopoietic reconstitution of the immune sys

Externí odkaz: https://doaj.org/article/c6a9e7e2512046fc8ea54b9f03241739

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Akademický článek

Direct antigen presentation is the canonical pathway of cytomegalovirus CD8 T-cell priming regulated by balanced immune evasion ensuring a strong antiviral response

Autor: Julia K. Büttner, Sara Becker, Annette Fink, Melanie M. Brinkmann, Rafaela Holtappels, Matthias J. Reddehase, Niels A. Lemmermann

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

CD8 T cells are important antiviral effectors in the adaptive immune response to cytomegaloviruses (CMV). Naïve CD8 T cells can be primed by professional antigen-presenting cells (pAPCs) alternatively by “direct antigen presentation” or “antig

Externí odkaz: https://doaj.org/article/79934bb9fe914af98a35679105d46474

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Akademický článek

Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells.

Autor: Rafaela Holtappels, Sara Becker, Sara Hamdan, Kirsten Freitag, Jürgen Podlech, Niels A Lemmermann, Matthias J Reddehase

Publikováno v: PLoS Pathogens, Vol 19, Iss 11, p e1011643 (2023)

Cytomegaloviruses (CMVs) are host species-specific in their replication. It is a hallmark of all CMVs that productive primary infection is controlled by concerted innate and adaptive immune responses in the immunocompetent host. As a result, the infe

Externí odkaz: https://doaj.org/article/a668b5d6160c4bbd85aac98867b819ba

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