Zobrazeno 1 - 10
of 1 207
pro vyhledávání: '"P. Hillmer"'
Autor:
Christoph Arolt, Andreas H. Scheel, Margaret Dugan, Robert Wild, Vanessa Richartz, Barbara Holz, Johannes Brägelmann, Svenja Wagener-Ryczek, Sabine Merkelbach-Bruse, Juergen Wolf, Reinhard Buettner, Luigi Catanzariti, Matthias Scheffler, Axel M. Hillmer
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-6 (2024)
Abstract Our recently published K1N2-score robustly predicts KEAP1/NFE2L2-mutations and pathway activation status, while its accessibility might be limited. We tested if the RNA expression data of six pathway-related genes and NQO1-IHC might be a rel
Externí odkaz:
https://doaj.org/article/76dc8f63fb394e5b86b259d9d82f8616
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Theories, models and frameworks (TMFs) are useful when implementing, evaluating and sustaining healthcare evidence-based interventions. Yet it can be challenging to identify an appropriate TMF for an implementation project. We dev
Externí odkaz:
https://doaj.org/article/1ad68676690348e89602a751d2fa2ed4
Autor:
Leen Naji, Brittany Dennis, Myanca Rodrigues, Monica Bawor, Alannah Hillmer, Caroul Chawar, Eve Deck, Andrew Worster, James Paul, Lehana Thabane, Zainab Samaan
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-7 (2024)
Abstract Background The fragility index is a statistical measure of the robustness or “stability” of a statistically significant result. It has been adapted to assess the robustness of statistically significant outcomes from randomized controlled
Externí odkaz:
https://doaj.org/article/6eb34485c72f460db4a74e8b21fcdb37
Autor:
Xiaodong Liu, Ke Zhang, Neslihan A. Kaya, Zhe Jia, Dafei Wu, Tingting Chen, Zhiyuan Liu, Sinan Zhu, Axel M. Hillmer, Torsten Wuestefeld, Jin Liu, Yun Shen Chan, Zheng Hu, Liang Ma, Li Jiang, Weiwei Zhai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Solid tumors are complex ecosystems with heterogeneous 3D structures, but the spatial intra-tumor heterogeneity (sITH) at the macroscopic (i.e., whole tumor) level is under-explored. Using a phylogeographic approach, we sequence genomes and
Externí odkaz:
https://doaj.org/article/60f8a1a01ce34a9880560aea46cda2b3
Autor:
Komal Aryal, Fabrice I. Mowbray, Anna Miroshnychenko, Ryan P. Strum, Darly Dash, Michael P. Hillmer, Kamil Malikov, Andrew P. Costa, Aaron Jones
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background SARS-CoV-2 vaccines are effective in reducing hospitalization, COVID-19 symptoms, and COVID-19 mortality for nursing home (NH) residents. We sought to compare the accuracy of various machine learning models, examine changes to mod
Externí odkaz:
https://doaj.org/article/b3042592d63d4b3e815897ef556bd313
Autor:
Patrick S. Plum, Timo Hess, Denis Bertrand, Isabelle Morgenstern, Oscar Velazquez Camacho, Christoph Jonas, Christina Alidousty, Britta Wagner, Stephanie Roessler, Thomas Albrecht, Jessica Becker, Vanessa Richartz, Barbara Holz, Sascha Hoppe, Huay Mei Poh, Burton Kuan Hui Chia, Cheryl Xueli Chan, Thushangi Pathiraja, Audrey SM Teo, Jens U. Marquardt, Alexis Khng, Michael Heise, Yao Fei, René Thieme, Sebastian Klein, Jing Han Hong, Simona O Dima, Irinel Popescu, Maria Hoppe‐Lotichius, Reinhard Buettner, Anja Lautem, Gerd Otto, Alexander Quaas, Niranjan Nagarajan, Steve Rozen, Bin Tean Teh, Benjamin Goeppert, Uta Drebber, Hauke Lang, Patrick Tan, Ines Gockel, Johannes Schumacher, Axel M. Hillmer
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Background Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct with a poor prognosis owing to limited therapeutic options. The incidence of intrahepatic CCA (iCCA) is increasing worldwide, and its molecular basis is emerging. Environ
Externí odkaz:
https://doaj.org/article/26260a111e4f40929c73d9cf914a4148
Autor:
Alexander Quaas, Julie George, Philipp Müller, Hans Anton Schlößer, Michael von Bergwelt-Baildon, Martin Thelen, Birgit Gathof, Martin Peifer, Thomas Zander, Axel M Hillmer, Christiane Bruns, Diandra Keller, Jonas Lehmann, Kerstin Wennhold, Eugen Bauer, Maria Alejandra Garcia-Marquez, Roman Thomas, Lukas Maas, Miloš Nikolić, Wolfgang Schröder, Ali M Yazbeck
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background The individual HLA-I genotype is associated with cancer, autoimmune diseases and infections. This study elucidates the role of germline homozygosity or allelic imbalance of HLA-I loci in esophago-gastric adenocarcinoma (EGA) and determines
Externí odkaz:
https://doaj.org/article/afc5d656bb5b494e9b31c5d4b6a0c547
Autor:
Janet Squires, Wilmer J. Santos, Ian D. Graham, Jamie Brehaut, Janet A. Curran, Jill J. Francis, Jeremy M. Grimshaw, Michael Hillmer, Noah Ivers, John Lavis, Susan Michie, Thomas Noseworthy, Alison M. Hutchinson
Publikováno v:
International Journal of Health Policy and Management, Vol 12, Iss Issue 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/6a94f692aa024f1e882076565cf60946
Autor:
Arvind Caprihan, Laura Hillmer, Erik Barry Erhardt, John C. Adair, Janice E. Knoefel, Jillian Prestopnik, Gary A. Rosenberg, for Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 10, Pp 1802-1815 (2023)
Abstract Introduction Diagnosis of dementia in the aging brain is confounded by the presence of multiple pathologies. Mixed dementia (MX), a combination of Alzheimer's disease (AD) proteins with vascular disease (VD), is frequently found at autopsy,
Externí odkaz:
https://doaj.org/article/770232db29f046f8b664576411a926f5
Autor:
Aidan McGraw, Grace Hillmer, Stefania M. Medehincu, Yuta Hikichi, Sophia Gagliardi, Kedhar Narayan, Hasset Tibebe, Dacia Marquez, Lilia Mei Bose, Adleigh Keating, Coco Izumi, Kevin Peese, Samit Joshi, Mark Krystal, Kathleen L. DeCicco-Skinner, Eric O. Freed, Luca Sardo, Taisuke Izumi
Publikováno v:
Viruses, Vol 16, Iss 9, p 1423 (2024)
HIV-1 virion maturation is an essential step in the viral replication cycle to produce infectious virus particles. Gag and Gag-Pol polyproteins are assembled at the plasma membrane of the virus-producer cells and bud from it to the extracellular comp
Externí odkaz:
https://doaj.org/article/80d24a174b6e4afea42006719a85adfb