Zobrazeno 1 - 10
of 118
pro vyhledávání: '"P. H. Van Der Meide"'
Autor:
J.M. Zuijderwijk, Willem Weimar, Leonard M.B. Vaessen, N.M. van Besouw, P H van der Meide, Aggie H.M.M. Balk, Alexander P.W.M. Maat
Publikováno v:
Clinical & Experimental Immunology, 141(3), 534-540. Wiley-Blackwell Publishing Ltd
SummaryAlloreactive T cells may be activated via a direct or an indirect antigen presentation pathway. We questioned whether the frequency of interferon (IFN)-γ producing cells determined by enzyme-linked immunospot (ELISPOT) assay is an effective t
Publikováno v:
Immunology. 101:397-403
Summary We have previously shown that tolerance can be induced against acute experimental autoimmune encephalomyelitis (EAE) in Lewis rats by bone marrow-derived dendritic cells (DC) that have been pulsed in vitro with encephalitogenic myelin basic p
Autor:
H. Lindå, Henrik Hammarberg, Anders Svenningsson, C. Lundberg, Tomas Olsson, Staffan Cullheim, A. W. Gielen, Fredrik Piehl, P. H. Van Der Meide, Olle Lidman, Sana Eltayeb, Saad Muhallab
Publikováno v:
Karolinska Institutet
Europe PubMed Central
Europe PubMed Central
In experimental autoimmune encephalomyelitis (EAE), CD4+self-reactive T cells target myelin components of the CNS. However, the consequences of an autoaggressive T cell response against myelin for neurons are currently unknown. We herein demonstrate
Publikováno v:
Clinical and Experimental Immunology. 120:526-531
SUMMARYMucosal myelin autoantigen administration effectively prevented EAE, but mostly failed to treat ongoing EAE. Patients with multiple sclerosis (MS), for which EAE is considered an animal model, did not benefit from oral treatment with bovine my
Publikováno v:
Scandinavian Journal of Immunology. 48:502-508
Astrocytes constitute a part of the blood-brain barrier. Chemokine expression by astrocytes may contribute to leucocyte infiltration within the central nervous system (CNS) during inflammation. To investigate factor(s) regulating chemokine expression
Autor:
Hans Link, Hu-Lun Li, Fu-Dong Shi, Bao-Guo Xiao, P. H. Van Der Meide, J.‐Q. Liu, Xue-Feng Bai
Publikováno v:
Clinical and Experimental Immunology. 111:205-210
EAE is an autoimmune disease of the central nervous system (CNS) that serves as an experimental model for the human inflammatory demyelinating disease multiple sclerosis (MS). Antigen-based immunotherapy including soluble antigen administration via f
Autor:
P. H. Van Der Meide, Huub Schellekens
Publikováno v:
Biotherapy. 10:39-48
Low amounts of high-affinity autoantibodies to various cytokines have been detected in sera from healthy donors. Their levels, although highly variable, are increased in the circulation of patients subjected to cytokine therapy or suffering from a va
Publikováno v:
Clinical and Experimental Immunology. 108:523-528
SUMMARY Age-related alterations in the immune system, including changes in lymphocyte subset composition, result in changes of cytokine patterns and might thereby influence the incidence and severity of autoimmune diseases. To investigate the age-rel
Autor:
P. H. Van Der Meide, Bao-Guo Xiao, Guang Xian Zhang, Hans Wigzell, Hans Link, Tomas Olsson, Moiz Bakhiet
Publikováno v:
The Journal of Experimental Medicine
CD4+ T cells have been shown to be crucial in the development of experimental autoimmune myasthenia gravis (EAMG). The role of CD8+ T cells in EAMG is less well established. We previously showed that antibody depletion of CD8+ T cells in rats effecti
Autor:
Els M. Seijmonsbergen, A. M. Van Furth, J. A. M. Langermans, R. Van Furth, P. H. Van Der Meide
Publikováno v:
Clinical Diagnostic Laboratory Immunology. 2:689-692
The present study concerns the release of the proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha and of the anti-inflammatory cytokine IL-10 by human leukocytes in whole blood during stimulation with Streptococcu