Zobrazeno 1 - 10 of 42 pro vyhledávání: '"P. H. Sugden"'
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Akademický článek
ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes.
Autor: Andrew K Marshall, Oliver P T Barrett, Timothy E Cullingford, Achchuthan Shanmugasundram, Peter H Sugden, Angela Clerk
Publikováno v: PLoS ONE, Vol 5, Iss 4, p e10027 (2010)
Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g. endothelin-1)] regulate gene expression and are implicated in the response
Externí odkaz: https://doaj.org/article/a5f889d6a8db46e181196577e51151c9
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2
Central effects of morphine and morphine-6-glucuronide on tissue protein synthesis
Autor: V. R. Preedy, Peter J. Garlick, Yojiro Hashiguchi, P. H. Sugden, Patricia E. Molina, Margaret A. McNurlan, Naji N. Abumrad
Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 271:R619-R625
The central and peripheral effects of morphine sulfate (Mor) and morphine-6-glucuronide (M6G) on the fractional rates of tissue protein synthesis (kappa s) were determined. We determined ks in conscious rats 2 h after intracerebroventricular injectio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095a14cd44b48fae9f7fd8410c3278db
https://doi.org/10.1152/ajpregu.1996.271.3.r619
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3
Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts
Autor: Angela Clerk, M B Anderson, Marie A. Bogoyevitch, P H Sugden
Publikováno v: Journal of Biological Chemistry. 269:32848-32857
The translocation of protein kinase C (PKC) isoforms PKC-alpha, PKC-delta, PKC-epsilon, and PKC-zeta from soluble to particulate fractions was studied in ventricular cardiomyocytes cultured from neonatal rats. Endothelin-1 (ET-1) caused a rapid ETA r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::540e04df6ab9214c3ed5213e76722a67
https://doi.org/10.1016/s0021-9258(20)30069-7
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4
Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis
Autor: P H, Sugden, S J, Fuller, S C, Weiss, A, Clerk
Publikováno v: British journal of pharmacology. 153
Glycogen synthase kinase 3 (GSK3, of which there are two isoforms, GSK3alpha and GSK3beta) was originally characterized in the context of regulation of glycogen metabolism, though it is now known to regulate many other cellular processes. Phosphoryla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc47d745031e7be6960657c0b0f73974
https://pubmed.ncbi.nlm.nih.gov/18204489
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5
Signalling pathways in cardiac myocyte hypertrophy
Autor: P H, Sugden
Publikováno v: Annals of medicine. 33(9)
In response to a requirement for increased contractile power in vivo, mammalian cardiac myocytes adapt through a hypertrophic response (cell enlargement in the absence of cell division). This response can be simulated by exposing isolated myocytes in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2248784b59fab5ab5650d60e567f18a
https://pubmed.ncbi.nlm.nih.gov/11817656
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6
Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras
Autor: A, Chiloeches, H F, Paterson, R, Marais, A, Clerk, C J, Marshall, P H, Sugden
Publikováno v: The Journal of biological chemistry. 274(28)
The small G protein Ras has been implicated in hypertrophy of cardiac myocytes. We therefore examined the activation (GTP loading) of Ras by the following hypertrophic agonists: phorbol 12-myristate 13-acetate (PMA), endothelin-1 (ET-1), and phenylep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c78cb3dfeb438a729aee494952f117ef
https://pubmed.ncbi.nlm.nih.gov/10391918
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9
Intracellular signalling through protein kinases in the heart
Autor: P H, Sugden, M A, Bogoyevitch
Publikováno v: Cardiovascular research. 30(4)
Protein kinases play important roles in intracellular signalling pathways in probably all cells. In the heart, they are involved in the regulation of ion handling, contractility, fuel metabolism and growth. In this review, we discuss the consequences
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55d570155aa6ecd70aa95fb9e3aabe5a
https://pubmed.ncbi.nlm.nih.gov/8574996
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10
Subcellular mechanism of the species difference in the contractile response of ventricular myocytes to endothelin-1
Autor: F, Del Monte, J R, Mynett, P H, Sugden, P A, Poole-Wilson, S E, Harding
Publikováno v: Cardioscience. 4(3)
The aim of the experiments was to compare the effects of endothelin and alpha-adrenoceptor stimulation on the contraction and inositol phosphate turnover of cardiomyocytes enzymatically isolated from rat and guinea-pig hearts. The effects of agonists
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05644d641acbca8780b2d48bbe2564b5
https://pubmed.ncbi.nlm.nih.gov/8400027
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