Zobrazeno 1 - 10
of 110
pro vyhledávání: '"P. H. Newman"'
Autor:
John P. Finnigan, Jenna H. Newman, Yury Patskovsky, Larysa Patskovska, Andrew S. Ishizuka, Geoffrey M. Lynn, Robert A. Seder, Michelle Krogsgaard, Nina Bhardwaj
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract T cell receptors (TCR) are pivotal in mediating tumour cell cytolysis via recognition of mutation-derived tumour neoantigens (neoAgs) presented by major histocompatibility class-I (MHC-I). Understanding the factors governing the emergence of
Externí odkaz:
https://doaj.org/article/c618911c78714f43801b9d080ea8aa73
Autor:
Isabel Neale, Mohammad Ali, Barbara Kronsteiner, Stephanie Longet, Priyanka Abraham, Alexandra S. Deeks, Anthony Brown, Shona C. Moore, Lizzie Stafford, Susan L. Dobson, Megan Plowright, Thomas A. H. Newman, Mary Y. Wu, Edward J. Carr, Rupert Beale, Ashley D. Otter, Susan Hopkins, Victoria Hall, Adriana Tomic, Rebecca P. Payne, Eleanor Barnes, Alex Richter, Christopher J. A. Duncan, Lance Turtle, Thushan I. de Silva, Miles Carroll, Teresa Lambe, Paul Klenerman, Susanna Dunachie
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Serological correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection after vaccination (“vaccine breakthrough”) have been described. However, T cell correlates of protection against breakthr
Externí odkaz:
https://doaj.org/article/62986889a29d4d32b1477e895ca6b6cd
Autor:
Anthony E. Postiglione, Laquaundra L. Adams, Ese S. Ekhator, Anuoluwapo E. Odelade, Supriya Patwardhan, Meenal Chaudhari, Avery S. Pardue, Anjali Kumari, William A. LeFever, Olivia P. Tornow, Tamer S. Kaoud, Johnathan Neiswinger, Jun Seop Jeong, Derek Parsonage, Kimberly J. Nelson, Dukka B. Kc, Cristina M. Furdui, Heng Zhu, Andrew J. Wommack, Kevin N. Dalby, Ming Dong, Leslie B. Poole, Jeremiah D. Keyes, Robert H. Newman
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107817- (2023)
Summary: Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are dysregulated in many pervasive diseases. Recently, we discovered that ERK1/2 is oxidized by signal-generated hydrogen peroxide in various cell types. Since the putative sites of oxi
Externí odkaz:
https://doaj.org/article/f86f308d6824464da8ac7565dac3a50d
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, regulation, and repair. Here, we present a novel approach that combines fea
Externí odkaz:
https://doaj.org/article/05ba5159bed749beae6d1133d9a0744b
Autor:
Sharad Goyal, Howard L Kaufman, Andrew Zloza, Ann W Silk, Vineet Gupta, Shang-Jui Wang, Bruce G Haffty, Nicole R LeBoeuf, Sachin R Jhawar, Jose A Guevara-Patino, Timothy M Kuzel, Jochen Reiser, Aditya Thandoni, Praveen K Bommareddy, Jenna H Newman, Amanda L Marzo, Preston Daniels, Devora Schiff, Darrion Mitchell, Christopher Simmons, Ahmed Lasfar, Eileena F Giurini
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 7 (2023)
Background Immunotherapies are becoming front-line treatments for many advanced cancers, and combinations of two or more therapies are beginning to be investigated. Based on their individual antitumor capabilities, we sought to determine whether comb
Externí odkaz:
https://doaj.org/article/aa466472bc1745428fedfc56b28b3f77
Autor:
Peter L. H. Newman, Queenie Yip, Pierre Osteil, Tim A. Anderson, Jane Q. J. Sun, Daryan Kempe, Maté Biro, Jae‐Won Shin, Patrick P. L. Tam, Hala Zreiqat
Publikováno v:
Advanced Science, Vol 10, Iss 15, Pp n/a-n/a (2023)
Abstract Multicellular patterning of stem‐cell‐derived tissue models is commonly achieved via self‐organizing activities triggered by exogenous morphogenetic stimuli. However, such tissue models are prone to stochastic behavior, limiting the re
Externí odkaz:
https://doaj.org/article/cbc5e417ee174b0e857397de61f20b58
Publikováno v:
ACS Omega, Vol 6, Iss 43, Pp 29166-29170 (2021)
Externí odkaz:
https://doaj.org/article/be721524c99a452590129357eac401bc
Autor:
Souhrid Mukherjee, Thomas A. Cassini, Ningning Hu, Tao Yang, Bian Li, Wangzhen Shen, Christopher W. Moth, David C. Rinker, Jonathan H. Sheehan, Joy D. Cogan, John H. Newman, Rizwan Hamid, Robert L. Macdonald, Dan M. Roden, Jens Meiler, Georg Kuenze, John A. Phillips, John A. Capra
Publikováno v:
HGG Advances, Vol 3, Iss 4, Pp 100131- (2022)
Summary: Whole-exome sequencing (WES) in the clinic has identified several rare monogenic developmental and epileptic encephalopathies (DEE) caused by ion channel variants. However, WES often fails to provide actionable insight for rare diseases, suc
Externí odkaz:
https://doaj.org/article/80f15d97adae43d6b743ecd6b1a9570f
Autor:
Jeannette Delva-Wiley, Ese S. Ekhator, Laquaundra L. Adams, Supriya Patwardhan, Ming Dong, Robert H. Newman
Publikováno v:
Life, Vol 13, Iss 9, p 1811 (2023)
The cyclic AMP-dependent protein kinase (PKA) plays an essential role in the regulation of many important cellular processes and is dysregulated in several pervasive diseases, including diabetes, cardiovascular disease, and various neurodegenerative
Externí odkaz:
https://doaj.org/article/dc1df490949b41d4a8ac8201d02cf07b
Autor:
Per Plenge, Dongxue Yang, Kristine Salomon, Louise Laursen, Iris E. Kalenderoglou, Amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Vilazodone (VLZ) is a drug for the treatment of major depressive disorders that targets the serotonin transporter (SERT). Here, the authors combine pharmacology measurements and cryo-EM structural analysis to characterize VLZ binding to SERT and obse
Externí odkaz:
https://doaj.org/article/7e4dd1b8938f4697aed6a531fb670e57