Zobrazeno 1 - 10
of 183
pro vyhledávání: '"P. H. Henning"'
Autor:
C. F. de Veij Mestdagh, M. E. Witte, W. Scheper, A. B. Smit, R. H. Henning, R. E. van Kesteren
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Tau protein hyperphosphorylation and aggregation are key pathological events in neurodegenerative tauopathies such as Alzheimer’s disease. Interestingly, seasonal hibernators show extensive tau hyperphosphorylation during torpor, i.e., the
Externí odkaz:
https://doaj.org/article/d6870aa00a0445b7a315974d71d57629
Autor:
Daniël H. Swart, Martin de Haan, Jasper Stevens, Rob H. Henning, Sovan Adel, Adrianus C. van der Graaf, Nadir Ulu, Daan J. Touw, Guido Krenning
Publikováno v:
Toxicology Reports, Vol 12, Iss , Pp 345-355 (2024)
Noncommunicable Chronic Diseases (NCD) are a socioeconomic burden and considered one of the major health challenges for coming decades. Mitochondrial dysfunction has been implicated mechanistically in their pathophysiology. Therefore, targeting mitoc
Externí odkaz:
https://doaj.org/article/b8f0e0d668de4738b59950a932a68715
Autor:
Marloes M. Oosterhof, Louis Coussement, Alienke van Pijkeren, Marcel Kwiatkowski, Martijn R. H. Zwinderman, Frank J. Dekker, Tim de Meyer, Vera A. Reitsema, Rainer Bischoff, Victor Guryev, Hjalmar R. Bouma, Rob H. Henning, Marianne G. Rots
Publikováno v:
Epigenetics Communications, Vol 4, Iss 1, Pp 1-14 (2024)
Abstract Background Hibernation (torpor) is a strategy to survive extreme environmental conditions, associated with a significant decrease in metabolism and body temperature. The inducibility by the environment of torpor for facultative hibernators d
Externí odkaz:
https://doaj.org/article/69c8df83b754412d957260d7a49f95cc
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/ee6781d79a524fc2b06120b92d98b73c
Autor:
D. Keskin Gokcelli, J. Itzhacki Sitton, J. Kesik, D. H. Henning, E. Farrher, N. J. Shah, T. Frodl
Publikováno v:
European Psychiatry, Vol 67, Pp S537-S537 (2024)
Introduction Dysfunctional changes in the glutamatergic system play an important role in the pathophysiology of depression. Glutamate regulates various neuronal function, such as nerve migration, excitability, plasticity, as well as long-term potenti
Externí odkaz:
https://doaj.org/article/599c9266864e40819f289a751cb03fcb
Publikováno v:
Frontiers in Neuroanatomy, Vol 18 (2024)
Hibernating animals demonstrate a remarkable ability to withstand extreme physiological brain changes without triggering adverse neuroinflammatory responses. While hibernators may offer valuable insights into the neuroprotective mechanisms inherent t
Externí odkaz:
https://doaj.org/article/946126b749954907beadf5cb3975b4d4
Autor:
Christina F. de Veij Mestdagh, Frank Koopmans, Jonathan C. Breiter, Jaap A. Timmerman, Pieter C. Vogelaar, Guido Krenning, Huibert D. Mansvelder, August B. Smit, Robert H. Henning, Ronald E. van Kesteren
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide and remains without effective cure. Increasing evidence is supporting the mitochondrial cascade hypothesis, proposing that loss of mitochondrial
Externí odkaz:
https://doaj.org/article/57d2e632022d4d42b3829a94237d7099
Plasma proteomic characterization of the development of acute kidney injury in early sepsis patients
Autor:
B. S. Star, C. K. Boahen, E. C. van der Slikke, V. M. Quinten, J. C. ter Maaten, R. H. Henning, V. Kumar, H. R. Bouma
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Acute kidney injury (AKI) develops frequently in the course of patients with sepsis and strongly associates with in-hospital mortality. However, diagnosing AKI involves a considerable lag-time because it depends on assessing an increase in s
Externí odkaz:
https://doaj.org/article/c2974c750eed4b0c9e0fc178db893755
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Hibernating mammals have developed many physiological adaptations to accommodate their decreased metabolism, body temperature, heart rate and prolonged immobility without suffering organ injury. During hibernation, the animals must suppress blood clo
Externí odkaz:
https://doaj.org/article/a47c8b08ef084e75b950b54e951782be
Publikováno v:
Cells, Vol 13, Iss 1, p 12 (2023)
Alzheimer’s disease (AD) is the most common cause of dementia worldwide and yet remains without effective therapy. Amongst the many proposed causes of AD, the mitochondrial cascade hypothesis is gaining attention. Accumulating evidence shows that m
Externí odkaz:
https://doaj.org/article/a83b6619eebc4dc4878643e2b1a315ce