Zobrazeno 1 - 10
of 24
pro vyhledávání: '"P. H. Hand"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Acidothermus cellulolyticus CRISPR-Cas9 (AceCas9) is a Type II-C enzyme that cleaves DNA in a Protospacer Adjacent Motif (PAM) methylation sensitive fashion. Biochemical analysis and crystal structures of AceCas9 in complex with sgRNA and DNA bearing
Externí odkaz:
https://doaj.org/article/2cea4907f71b47c69f5853d72886df10
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
There is significant interest in providing real-world applications for metamaterials. Here, the authors design an Advanced Short Backfire Antenna, augmented with anisotropic metamaterial surfaces to achieve high aperture efficiency across two frequen
Externí odkaz:
https://doaj.org/article/ccff17c0b33e4c0a9a9e851e99379dfe
Autor:
P H, HAND
Publikováno v:
Veterinary medicine. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ba483de4f4fb1398fdc193a809ad053
https://pubmed.ncbi.nlm.nih.gov/21009496
https://pubmed.ncbi.nlm.nih.gov/21009496
Generation and characterization of a single gene-encoded single-chain-tetravalent antitumor antibody
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5
Monoclonal antibody (mAb) CC49, a murine IgG1, reacts with the tumor-associated glycoprotein-72 expressed on a variety of carcinomas. In clinical trials, radiolabeled CC49 has shown excellent tumor localization to a variety of carcinomas. To minimize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6bc460ef1000de7827383401a3336ee8
https://pubmed.ncbi.nlm.nih.gov/10541352
https://pubmed.ncbi.nlm.nih.gov/10541352
Publikováno v:
Seminars in oncology. 23(1)
The ras p21 proto-oncogenes (ie, K-ras, H-ras, N-ras) encode a family of proteins vital to cellular signaling and function. Point mutations in these genes have been found in a wide diversity of human cancers, suggesting a strong association in the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d16959cdf7ecd0e0b8845ec3fca714c
https://pubmed.ncbi.nlm.nih.gov/8607022
https://pubmed.ncbi.nlm.nih.gov/8607022
Publikováno v:
Cancer research. 55(11)
Human prostate-specific antigen (PSA) has been shown as an aid in the early detection of prostate cancer (W. J. Catalona et al., J. Am. Med. Assoc., 270: 948-954, 1993) and was approved in 1994 by the Food and Drug Administration for early detection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2144ebc2ea2ec8b0a53d2167038e4c3
https://pubmed.ncbi.nlm.nih.gov/7538903
https://pubmed.ncbi.nlm.nih.gov/7538903
Publikováno v:
Cancer. 73
Numerous monoclonal antibodies (MoAb) have been developed and currently are being evaluated in both diagnostic and therapeutic clinical trials. Despite the major advances fostered by MoAb technology, several limitations inherent to the use of MoAb ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e35bcee62839e1e23f19840316b24a15
https://pubmed.ncbi.nlm.nih.gov/8306254
https://pubmed.ncbi.nlm.nih.gov/8306254
Autor:
K, Siler, D, Eggensperger, P H, Hand, D E, Milenic, L S, Miller, D P, Houchens, G, Hinkle, J, Schlom
Publikováno v:
Biotechnology therapeutics. 4(3-4)
COL-1 is a murine IgG2a monoclonal antibody (MAb) with a high affinity (1.4 x 10(9) M-1) for carcinoembryonic antigen (CEA) and no detectable reactivity for CEA-related antigens, such as nonspecific cross-reacting antigen (NCA) and normal fecal antig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff2ac231308a75dd16929c56f6fda788
https://pubmed.ncbi.nlm.nih.gov/8292968
https://pubmed.ncbi.nlm.nih.gov/8292968
Publikováno v:
Cancer research. 51(14)
A cell line derived from the mouse colon adenocarcinoma, MC-38, has been transduced with a retroviral construct containing complementary DNA encoding the human carcinoembryonic antigen (CEA) gene. MC-38, which forms tumors in syngeneic C57BL/6 mice,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59e8dc0a937b672b34fe996838b8eda0
https://pubmed.ncbi.nlm.nih.gov/1712245
https://pubmed.ncbi.nlm.nih.gov/1712245
Publikováno v:
Anticancer research. 11(4)
A monoclonal antibody, RAP-5, raised against the 21,000d ras-oncogene product, p21, was used in an immunoperoxidase staining procedure to study the expression of p21 in normal children's and foetal kidneys, pre-malignant lesions and benign and malign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48c6b6520635681f419924f1d9c49026
https://pubmed.ncbi.nlm.nih.gov/1660693
https://pubmed.ncbi.nlm.nih.gov/1660693