Zobrazeno 1 - 10
of 21
pro vyhledávání: '"P. Grant Spoors"'
Autor:
Daniel B. Patience, Lynette M. Oh, Huan Wang, Joseph Sisko, P. Grant Spoors, Robert E. Herrmann, Susan Shilcrat
Publikováno v:
Organic Process Research & Development. 11:1032-1042
A scalable synthesis of GSK183390A, a PPAR α/γ agonist, is described. This synthesis is highlighted by (1) a regioselective formal 1,3-dipolar cycloaddition reaction between an enamine and a nitrile imine dipole to form a 1,3,5-trisubstituted pyraz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f899fde00e5f2a1dd470adcc0803e088
https://doi.org/10.1021/op700164t
https://doi.org/10.1021/op700164t
Publikováno v:
Tetrahedron Letters. 42:1781-1784
Reaction of silylated guanine derivatives with 2-acetoxy-4-benzoyloxymethyltetrahydrofuran in DMF or NMP resulted in selective N-9 alkylation. This was used as the basis for a regioselective synthesis of the anti-viral agents famciclovir and penciclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed220e7a9a75f7f3e26fa926a1e5432c
https://doi.org/10.1016/s0040-4039(00)02326-1
https://doi.org/10.1016/s0040-4039(00)02326-1
Publikováno v:
Tetrahedron Letters. 41:2269-2273
A number of aromatic dibromides have been treated with 2–3 equivalents of n-butyllithium in order to initiate two sequential chemical events, a Parham cyclization and an intermolecular reaction with DMF.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5b168467d78b83e676ecb551841fb57
https://doi.org/10.1016/s0040-4039(00)00159-3
https://doi.org/10.1016/s0040-4039(00)00159-3
Autor:
Kenneth G. Hull, Gregory K. Friestad, Makoto Iwashima, Amos B. Smith, Emmanuel Bertounesque, Jingwu Duan, Brian A. Salvatore, Joseph Barbosa, and P. Grant Spoors, Yuping Qiu
Publikováno v:
Journal of the American Chemical Society. 121:10468-10477
An asymmetric synthesis of the stereochemically fully endowed C(9−25) spiroketal fragment (+)-BC of the calyculins (1−8) is described. Highlights of the synthesis include: a highly diastereoselective IBr-induced iodocarbonate cyclization to intro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38a6cd85f42fe5e55798d843f5a7ed2c
https://doi.org/10.1021/ja992134m
https://doi.org/10.1021/ja992134m
Autor:
Yuping Qiu, Kenneth G. Hull, and P. Grant Spoors, Brian A. Salvatore, Emmanuel Bertounesque, Jingwu Duan, Makoto Iwashima, Joseph Barbosa, Amos B. Smith, Gregory K. Friestad
Publikováno v:
Journal of the American Chemical Society. 121:10478-10486
A convergent total synthesis leading to (+)-calyculin A and (−)-calyculin B (1 and 2), antipodes of the potent, highly selective and remarkably cell-permeable phosphatase inhibitors calyculins A and B, has been achieved. In the preceding paper we o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7fca728ebfd651759540bd73fb55e9c
https://doi.org/10.1021/ja992135e
https://doi.org/10.1021/ja992135e
Publikováno v:
Israel Journal of Chemistry. 37:69-80
An efficient third-generation asymmetric synthesis of tricyclic lactone (+)-1, designed to serve as the common intermediate for construction of the indole tremorgens, has been developed. The major challenge was stereocontrolled introduction of the vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3b2c943726f8b0313ac1785230cc031
https://doi.org/10.1002/ijch.199700009
https://doi.org/10.1002/ijch.199700009
Publikováno v:
Tetrahedron Letters. 45:4769-4771
A new and convenient method of generating phenyl isocyanates from anilines using oxalyl chloride is described. Acylation of a variety of substituted aniline hydrochlorides with oxalyl chloride affords the intermediate oxamic chlorides, which smoothly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1ada652ac0dffd0b26076f07617471
https://doi.org/10.1016/j.tetlet.2004.04.043
https://doi.org/10.1016/j.tetlet.2004.04.043
Autor:
Paul T. Buonora, Kenneth J. Wilson, P. Grant Spoors, Glenn J. McGarvey, Kenneth R. Overly, Jeffrey A. Mathys
Publikováno v:
The Journal of Organic Chemistry. 60:7778-7790
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07815f4a3b0f9aabfcb7f7b042623ab7
https://doi.org/10.1021/jo00129a019
https://doi.org/10.1021/jo00129a019
Publikováno v:
Tetrahedron Letters. 36:2373-2376
Measurements of H2 evolution revealed that neither 5-trifluoroacetamido-1-pentanol (1) nor 5-acetamido-1-pentanol (6) underwent complete bisdeprotonation upon treatment with excess NaH in THF, thereby accounting for the unexpected course of subsequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::588bf1dc4654fe770c402cd1f41f3437
https://doi.org/10.1016/0040-4039(95)00280-p
https://doi.org/10.1016/0040-4039(95)00280-p
Autor:
William C. Shakespeare, Ralph Hirschmann, J. Salvino, Maria A. Cichy, E. M. Leahy, Byron H. Arison, P. Grant Spoors, S. Pietranico, Kyriacos C. Nicolaou
Publikováno v:
Journal of the American Chemical Society. 115:12550-12568
Non-peptide peptidomimetics of the peptide hormone somatostatin (SRIF) were designed and synthesized, utilizing Q-D-glucose as a novel scaffolding. Such compounds resemble conventional peptide analogs in that they retain critical amino acid side chai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f7652a97f1bbec7c3c71b3c29d6412c
https://doi.org/10.1021/ja00079a039
https://doi.org/10.1021/ja00079a039