Zobrazeno 1 - 10
of 13
pro vyhledávání: '"P. Githure M'Angale"'
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108048- (2023)
Summary: The formation, expansion, and pruning of synapses, known as structural synaptic plasticity, is needed for learning and memory, and perturbation of plasticity is associated with many neurological disorders and diseases. Previously, we observe
Externí odkaz:
https://doaj.org/article/cfe0f2f073e0467d8034a7ef4238563e
Autor:
P. Githure M’Angale, Brian E. Staveley
Publikováno v:
BMC Research Notes, Vol 10, Iss 1, Pp 1-9 (2017)
Abstract Background The identification of a DNA variant in pyridoxal kinase (Pdxk) associated with increased risk to Parkinson disease (PD) gene led us to study the inhibition of this gene in the Dopa decarboxylase (Ddc)-expressing neurons of the wel
Externí odkaz:
https://doaj.org/article/500005df100441fd8221d5b7f81810ee
Autor:
P. Githure M’Angale, Brian E. Staveley
Publikováno v:
PeerJ, Vol 5, p e2974 (2017)
Background Bax inhibitor-1 (BI-1) is an evolutionarily conserved cytoprotective transmembrane protein that acts as a suppressor of Bax-induced apoptosis by regulation of endoplasmic reticulum stress-induced cell death. We knocked down BI-1 in the sen
Externí odkaz:
https://doaj.org/article/e6e8ec2407ff4bcaa5a0ca3ac4694f69
Autor:
P. Githure M’Angale, Brian E. Staveley
Publikováno v:
PeerJ, Vol 4, p e2461 (2016)
Background Parkinson disease (PD) is a debilitating movement disorder that afflicts 1–2% of the population over 50 years of age. The common hallmark for both sporadic and familial forms of PD is mitochondrial dysfunction. Mammals have at least twen
Externí odkaz:
https://doaj.org/article/e4ff1191adfc49ddbf20a98a436c928b
Autor:
P. Githure M’Angale, Brian E. Staveley
Publikováno v:
Genome. 60:241-247
Mutations in parkin (PARK2) and Pink1 (PARK6) are responsible for autosomal recessive forms of early onset Parkinson’s disease (PD). Attributed to the failure of neurons to clear dysfunctional mitochondria, loss of gene expression leads to loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c8ddd6b0854ae519941051ddec902f
https://doi.org/10.1139/gen-2016-0165
https://doi.org/10.1139/gen-2016-0165
Autor:
P. Githure M’Angale, Brian E. Staveley
Publikováno v:
Genome. 60:1-7
Mutations in High temperature requirement A2 (HtrA2), also designated PARK13, which lead to the loss of its protease activity, have been associated with Parkinson’s disease (PD). HtrA2 is a mitochondrial protease that translocates to the cytosol up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcaad901a88bdf227dc5050e2342943
https://doi.org/10.1139/gen-2016-0069
https://doi.org/10.1139/gen-2016-0069
Autor:
P. Githure M’Angale, Brian E. Staveley
Publikováno v:
Journal of Biomedical Science
Background Mitochondrial porin, also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97263f8283ce4d01218ee9c600174247
https://doi.org/10.1186/s12929-016-0300-1
https://doi.org/10.1186/s12929-016-0300-1
Autor:
P. Githure M’Angale, Brian E. Staveley
Background. Bax Inhibitor-1 (BI-1), an integral transmembrane protein, acts as a suppressor of Bax-induced apoptosis through regulation of endoplasmic reticulum (ER) stress-induced cell death. The gene is highly conserved being found in a diverse ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6126b92f644d339bd36247c056930f21
Autor:
Brian E. Staveley, P. Githure M’Angale
Publikováno v:
PeerJ
PeerJ, Vol 4, p e2461 (2016)
PeerJ, Vol 4, p e2461 (2016)
BackgroundParkinson disease (PD) is a debilitating movement disorder that afflicts 1–2% of the population over 50 years of age. The common hallmark for both sporadic and familial forms of PD is mitochondrial dysfunction. Mammals have at least twent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174834ca375f65de978938d45c49eeea
http://europepmc.org/articles/PMC5028777
http://europepmc.org/articles/PMC5028777
Autor:
Brian E. Staveley, P. Githure M’Angale
Publikováno v:
BMC Neuroscience
Background In contrast to the complexity found in mammals, only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. The directed expression of α-synuclein, the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129b854fe03aa3483d8acf78ef3b5459
https://doi.org/10.1186/s12868-016-0261-z
https://doi.org/10.1186/s12868-016-0261-z