A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions

Autor: Hasier Eraña, Cristina Sampedro-Torres-Quevedo, Jorge M. Charco, Carlos M. Díaz-Domínguez, Francesca Peccati, Maitena San-Juan-Ansoleaga, Enric Vidal, Nuno Gonçalves-Anjo, Miguel A. Pérez-Castro, Ezequiel González-Miranda, Patricia Piñeiro, Leire Fernández-Veiga, Josu Galarza-Ahumada, Eva Fernández-Muñoz, Guiomar Perez de Nanclares, Glenn Telling, Mariví Geijo, Gonzalo Jiménez-Osés, Joaquín Castilla

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Prion diseases are a group of rapidly progressing neurodegenerative disorders caused by the misfolding of the endogenous prion protein (PrPC) into a pathogenic form (PrPSc). This process, despite being the central event underlying these diso

Externí odkaz: https://doaj.org/article/a04d98f58ccd4cb2b901a29e2c563eae

Insights into the function of ESCRT complex and LBPA in ASFV infection

Autor: Lucía Barrado-Gil, Isabel García-Dorival, Inmaculada Galindo, Covadonga Alonso, Miguel Ángel Cuesta-Geijo

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

The African swine fever virus (ASFV) is strongly dependent on an intact endocytic pathway and a certain cellular membrane remodeling for infection, possibly regulated by the endosomal sorting complexes required for transport (ESCRT). The ESCRT machin

Externí odkaz: https://doaj.org/article/8b2e9f316ee34aac950aac70aca1c9cf

EFFECTS OF LIS1 MUTATION ON THE DEVELOPMENT OF SOMATOSTATIN-POSITIVE INTERNEURONS OF THE CINGULATE CORTEX.

Autor: Ana Pombero, Raquel Garcia-Lopez, Emilio Geijo, Salvador Martinez

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S127- (2023)

Externí odkaz: https://doaj.org/article/e4f663f9577c44d7ba3cabd224940433

Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model

Autor: Enric Vidal, Manuel A. Sánchez-Martín, Hasier Eraña, Sonia Pérez Lázaro, Miguel A. Pérez-Castro, Alicia Otero, Jorge M. Charco, Belén Marín, Rafael López-Moreno, Carlos M. Díaz-Domínguez, Mariví Geijo, Montserrat Ordóñez, Guillermo Cantero, Michele di Bari, Nuria L. Lorenzo, Laura Pirisinu, Claudia d’Agostino, Juan María Torres, Vincent Béringue, Glenn Telling, Juan J. Badiola, Martí Pumarola, Rosa Bolea, Romolo Nonno, Jesús R. Requena, Joaquín Castilla

Publikováno v: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)

Abstract Atypical Scrapie, which is not linked to epidemics, is assumed to be an idiopathic spontaneous prion disease in small ruminants. Therefore, its occurrence is unlikely to be controlled through selective breeding or other strategies as it is d

Externí odkaz: https://doaj.org/article/ec75bdeb108f452fac8587687f697f39

Corrigendum to 'Dissecting the genetic heterogeneity of gastric cancer'

Autor: Timo Hess, Carlo Maj, Jan Gehlen, Oleg Borisov, Stephan L. Haas, Ines Gockel, Michael Vieth, Guillaume Piessen, Hakan Alakus, Yogesh Vashist, Carina Pereira, Michael Knapp, Vitalia Schüller, Alexander Quaas, Heike I. Grabsch, Jessica Trautmann, Ewa Malecka-Wojciesko, Anna Mokrowiecka, Jan Speller, Andreas Mayr, Julia Schröder, Axel M. Hillmer, Dominik Heider, Florian Lordick, Ángeles Pérez-Aísa, Rafael Campo, Jesús Espinel, Fernando Geijo, Concha Thomson, Luis Bujanda, Federico Sopeña, Ángel Lanas, María Pellisé, Claudia Pauligk, Thorsten Oliver Goetze, Carolin Zelck, Julian Reingruber, Emadeldin Hassanin, Peter Elbe, Sandra Alsabeah, Mats Lindblad, Magnus Nilsson, Nicole Kreuser, René Thieme, Francesca Tavano, Roberta Pastorino, Dario Arzani, Roberto Persiani, Jin-On Jung, Henrik Nienhüser, Katja Ott, Ralf R. Schumann, Oliver Kumpf, Susen Burock, Volker Arndt, Anna Jakubowska, Małgorzta Ławniczak, Victor Moreno, Vicente Martín, Manolis Kogevinas, Marina Pollán, Justyna Dąbrowska, Antonio Salas, Olivier Cussenot, Anne Boland-Auge, Delphine Daian, Jean-Francois Deleuze, Erika Salvi, Maris Teder-Laving, Gianluca Tomasello, Margherita Ratti, Chiara Senti, Valli De Re, Agostino Steffan, Arnulf H. Hölscher, Katharina Messerle, Christiane Josephine Bruns, Armands Sīviņš, Inga Bogdanova, Jurgita Skieceviciene, Justina Arstikyte, Markus Moehler, Hauke Lang, Peter P. Grimminger, Martin Kruschewski, Nikolaos Vassos, Claus Schildberg, Philipp Lingohr, Karsten Ridwelski, Hans Lippert, Nadine Fricker, Peter Krawitz, Per Hoffmann, Markus M. Nöthen, Lothar Veits, Jakob R. Izbicki, Adrianna Mostowska, Federico Martinón-Torres, Daniele Cusi, Rolf Adolfsson, Geraldine Cancel-Tassin, Aksana Höblinger, Ernst Rodermann, Monika Ludwig, Gisela Keller, Andres Metspalu, Hermann Brenner, Joerg Heller, Markus Neef, Michael Schepke, Franz Ludwig Dumoulin, Lutz Hamann, Renato Cannizzaro, Michele Ghidini, Dominik Plaßmann, Michael Geppert, Peter Malfertheiner, Olivier Glehen, Tomasz Skoczylas, Marek Majewski, Jan Lubiński, Orazio Palmieri, Stefania Boccia, Anna Latiano, Nuria Aragones, Thomas Schmidt, Mário Dinis-Ribeiro, Rui Medeiros, Salah-Eddin Al-Batran, Mārcis Leja, Juozas Kupcinskas, María A. García-González, Marino Venerito, Johannes Schumacher

Publikováno v: EBioMedicine, Vol 94, Iss , Pp 104709- (2023)

Externí odkaz: https://doaj.org/article/095484ffbd5043c092541fc7d85f94c6