Zobrazeno 1 - 10
of 459
pro vyhledávání: '"P. Galione"'
Autor:
Thamali Ayagama, Philip D. Charles, Samuel J. Bose, Barry Boland, David A. Priestman, Daniel Aston, Georgina Berridge, Roman Fischer, Adam P. Cribbs, Qianqian Song, Gary R. Mirams, Kwabena Amponsah, Lisa Heather, Antony Galione, Neil Herring, Holger Kramer, Rebecca A. Capel, Frances M. Platt, Ulrich Schotten, Sander Verheule, Rebecca A.B. Burton
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109609- (2024)
Summary: Endolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL facilitate the elimination of damaged membranes, protein aggregates, membranous organelles and play an important role in calcium si
Externí odkaz:
https://doaj.org/article/5ce7e4802b624eb9b2d4d4afc4a88738
Publikováno v:
Energies, Vol 17, Iss 19, p 4982 (2024)
This work presents a comprehensive model for lignocellulosic biomass pyrolysis, addressing kinetics, energy balances, and gas product composition with the aim of its application in wood combustion. The model consists of a two-stage global mechanism i
Externí odkaz:
https://doaj.org/article/3f464eba364a454babe34ed2208275b6
Akademický článek
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Autor:
T Fields, T M. Bremova, I Billington, GC Churchill, W Evans, C Fields, A Galione, R Kay, T Mathieson, K Martakis, M Patterson, F Platt, M Factor, M Strupp
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Background Niemann-Pick disease type C (NPC) is a rare autosomal recessive neurodegenerative lysosomal disease characterized by multiple symptoms such as progressive cerebellar ataxia and cognitive decline. The modified amino acid N-acetyl-l
Externí odkaz:
https://doaj.org/article/b2d970821a9f469ab49d495161a18d9d
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S765- (2023)
Externí odkaz:
https://doaj.org/article/366ddc4794b445b2b422247be4a03342
Akademický článek
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Akademický článek
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Autor:
Grant C. Churchill, Michael Strupp, Cailley Factor, Tatiana Bremova-Ertl, Mallory Factor, Marc C. Patterson, Frances M. Platt, Antony Galione
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Small changes to molecules can have profound effects on their pharmacological activity as exemplified by the addition of the two-carbon acetyl group to make drugs more effective by enhancing their pharmacokinetic or pharmacodynamic propertie
Externí odkaz:
https://doaj.org/article/8ec79fdb99cd4403ad6f39300b2c4f15
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Pancreatic β-cells release insulin upon a rise in blood glucose. The precise mechanisms of stimulus-secretion coupling, and its failure in Diabetes Mellitus Type 2, remain to be elucidated. The consensus model, as well as a class of current
Externí odkaz:
https://doaj.org/article/9045c5c0e3dc4eeb89bc5c8eecf10a5d
Autor:
Aarti Jagannath, Norbert Varga, Robert Dallmann, Gianpaolo Rando, Pauline Gosselin, Farid Ebrahimjee, Lewis Taylor, Dragos Mosneagu, Jakub Stefaniak, Steven Walsh, Teele Palumaa, Simona Di Pretoro, Harshmeena Sanghani, Zeinab Wakaf, Grant C. Churchill, Antony Galione, Stuart N. Peirson, Detlev Boison, Steven A. Brown, Russell G. Foster, Sridhar R. Vasudevan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms are unclear. Here, the authors show that adenosine A1/A2A receptor antagonists, such as caffeine, shift circadian rhythms and enhance the effects of light,
Externí odkaz:
https://doaj.org/article/fe29a732cf334692a98923abc1d068d8