Zobrazeno 1 - 10
of 17
pro vyhledávání: '"P. G. Wainwright"'
Autor:
David Leese, Donald Stuart Middleton, James Hart, Rebecca Glen, Xiurong Zhang, David C. Pryde, P. G. Wainwright, Neil Forrest, Thierry Guyot, Adrian Maddaford, Peter T. Stephenson
Publikováno v:
Tetrahedron Letters. 52:6415-6419
Robust practical routes to three different carbon-substituted nucleosides are described. Short synthetic procedures for preparing 1′-homonucleosides, 2′- C -methyl-carbanucleosides and 2′- C -methyl-cyclopropyl/cyclopentyl fused bicyclic ribose
Autor:
Neil Forrest, Michael J. Simms, Adrian Maddaford, Rebecca Glen, Peter T. Stephenson, Xiurong Zhang, Sutton Scott Channing, David C. Pryde, Thierry Guyot, Donald Stuart Middleton, James Hart, P. G. Wainwright
Publikováno v:
Synlett. 2011:1900-1904
A novel systematic approach to the synthesis of 2-cyano-7-deaza-8-azapurinederived nucleosides is described. It is shown how this chemistrywas developed with the labile 2-substituted nitrile position inmind, and also how the same approach is applicab
Autor:
Rebecca Glen, Pei-Pei Kung, Sutton Scott Channing, Donald Stuart Middleton, Peter S. Stephenson, Javier González, Ray Fisher, David C. Pryde, Peter S. Dragovich, Adrian Maddaford, P. G. Wainwright
Publikováno v:
Synthesis. 2007:1378-1384
Synthesis of a RACEMIC 4′-ethynyl-2′-deoxyribose intermediate using stereoselective chelation control is presented. This intermediate is further transformed to 4′-ethynyl-2′-deoxy- and 4′-ethynyl-2′,3′-dideoxy-2′,3′-didehydronucleos
Publikováno v:
Tetrahedron. 57:2391-2402
In this paper, we describe the synthesis of a series of chiral quaternary ammonium salts with core structures that are closely related to the cinchona alkaloid, cinchonine. By employing these salts as asymmetric phase-transfer agents in the benzylati
Publikováno v:
Tetrahedron. 57:2403-2409
In this paper, we describe investigations into the use of cinchona alkaloid-derived quaternary ammonium phase-transfer catalysts for the asymmetric alkylation of a benzophenone-derived glycine-imine. Utility of this process is demonstrated by the ena
Autor:
P. G. Wainwright, Barry Lygo
Publikováno v:
Tetrahedron. 55:6289-6300
A study into the enantioselective epoxidation of α,β-unsaturated ketones utilising Cinchona alkaloid-derived quaternary ammonium phase-transfer catalysts bearing an N-anthracenylmethyl function is presented. It has been found that the O-benzyl deri
Publikováno v:
Tetrahedron. 55:2795-2810
Highly enantio- and diastereoselective routes to 2-hydroxymethylquinuclidines have been developed. Key steps involve the use of Sharpless dihydroxylation or Sharpless epoxidation to introduce the asymmetry with high stereocontrol, and formation of th
Autor:
P. G. Wainwright, Barry Lygo
Publikováno v:
Tetrahedron Letters. 39:1599-1602
The enantioselective epoxidation of α,β-unsaturated ketones utilising Cinchona alkaloid-derived quaternary ammonium phase-transfer catalysts bearing an N-anthracenylmethyl function are presented. It has been found that the O-benzyl derivatives of t
Autor:
Barry Lygo, P. G. Wainwright
Publikováno v:
Tetrahedron Letters. 38:8595-8598
A new class of Cinchona alkaloid-derived quaternary ammonium phase-transfer catalysts bearing a N-anthracenylmethyl function are presented. These catalysts show high stereocontrol in the asymmetric alkylation of a benzophenone-derived glycine-imine,
Publikováno v:
Tetrahedron Letters. 38:2343-2346
An enantio- and diastereoselective synthesis of all four possible stereoisomers of 2-(phenylhydroxymethyl)quinuclidine is reported. Key steps involve the use of the Sharpless dihydroxylation protocol to induce asymmetry, and stereodivergent cyclisati