Zobrazeno 1 - 10
of 20
pro vyhledávání: '"P. G. Telford"'
Autor:
Roland C. Schelker, Jessica Fioravanti, Fabio Mastrogiovanni, Jeremy G. Baldwin, Nisha Rana, Peng Li, Ping Chen, Timea Vadász, Rosanne Spolski, Christoph Heuser-Loy, Dragana Slavkovic-Lukic, Pedro Noronha, Giuseppe Damiano, Laura Raccosta, Daniela Maggioni, Sree Pullugula, Jian-Xin Lin, Jangsuk Oh, Patrick Grandinetti, Mario Lecce, Leo Hesse, Emilia Kocks, Azucena Martín-Santos, Claudia Gebhard, William G. Telford, Yun Ji, Nicholas P. Restifo, Vincenzo Russo, Michael Rehli, Wolfgang Herr, Warren J. Leonard, Luca Gattinoni
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract High frequencies of stem-like memory T cells in infusion products correlate with superior patient outcomes across multiple T cell therapy trials. Herein, we analyzed a published CRISPR activation screening to identify transcriptional regulat
Externí odkaz:
https://doaj.org/article/feb411feca9c417783b76fb6c8d7a885
Autor:
William G. Telford
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
While flow cytometry is a critical single cell analytical technique in biomedical science, the technology of flow cytometry associated cell sorting is equally important. Physical separation of cells analyzed by flow cytometry was recognized as an imp
Externí odkaz:
https://doaj.org/article/850b3e146c4a40239abe2aa9a2ccbdf1
Autor:
Yun Ji, Jessica Fioravanti, Wei Zhu, Hongjun Wang, Tuoqi Wu, Jinhui Hu, Neal E. Lacey, Sanjivan Gautam, John B. Le Gall, Xia Yang, James D. Hocker, Thelma M. Escobar, Shan He, Stefania Dell’Orso, Nga V. Hawk, Veena Kapoor, William G. Telford, Luciano Di Croce, Stefan A. Muljo, Yi Zhang, Vittorio Sartorelli, Luca Gattinoni
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD
Externí odkaz:
https://doaj.org/article/f7106871939f484092d79cd389893db3
Autor:
Elena I. Kovalenko, Ivan V. Zvyagin, Maria A. Streltsova, Artem I. Mikelov, Sofya A. Erokhina, William G. Telford, Alexander M. Sapozhnikov, Yury B. Lebedev
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for NKG2C expression. In both CD56+ and CD56− subsets most of the NKG2C+ T cells had a phenot
Externí odkaz:
https://doaj.org/article/acce40ba91d940298fca962bf001f776
Autor:
Leonid M. Kanevskiy, Sofya A. Erokhina, Maria A. Streltsova, Rustam H. Ziganshin, William G. Telford, Alexander M. Sapozhnikov, Elena I. Kovalenko
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
NK cells can be stimulated by bacterial lipopolysaccharides (LPS). Unlike macrophages, human NK cells do not express or express very low level of surface TLR4 receptor normally required for the LPS stimulation. This has led to the assumption that the
Externí odkaz:
https://doaj.org/article/850e759f98f8404cbb0f02bf8fafba53
Autor:
Maria A Streltsova, Sofya A Erokhina, Leonid M Kanevskiy, Dean A Lee, William G Telford, Alexander M Sapozhnikov, Elena I Kovalenko
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208469 (2018)
In this work, we analyzed the phenotype and growth of human NK cell clones obtained by the stimulation of individual NK cells with IL-2 and gene-modified K562 feeder cells expressing membrane-bound IL-21 (K562-mbIL21). We generated clones from NK cel
Externí odkaz:
https://doaj.org/article/d5f71890394548f8b576bb02ef75e0c9
Autor:
William G Telford, Daria M Shcherbakova, David Buschke, Teresa S Hawley, Vladislav V Verkhusha
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122342 (2015)
Engineering of fluorescent proteins (FPs) has followed a trend of achieving longer fluorescence wavelengths, with the ultimate goal of producing proteins with both excitation and emission in the near-infrared (NIR) region of the spectrum. Flow cytome
Externí odkaz:
https://doaj.org/article/4ec50a1189c24d0b98948d9573f1d6a4
Publikováno v:
BioTechniques, Vol 30, Iss 5, Pp 1028-1034 (2001)
Flow cytometric procedures are described to detect a “humanized” version of a new red fluorescent protein (DsRed) from the coral Discosomasp. in conjunction with various combinations of three Aequorea victoria green fluorescent protein (GFP) vari
Externí odkaz:
https://doaj.org/article/b5debcfd537f47b48fe96ce387bcadbc
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
NK cells have been shown to play a regulatory role in sepsis. According to the current view, NK cells become activated via macrophages or dendritic cells primed by lipopolysaccharide (LPS). Recently TLR4 gene expression was detected in human NK cells
Externí odkaz:
https://doaj.org/article/27ce294f327e412f9f8a67d091736ce7
Autor:
Shoba Amarnath, Carliann M Costanzo, Jacopo Mariotti, Jessica L Ullman, William G Telford, Veena Kapoor, James L Riley, Bruce L Levine, Carl H June, Timothy Fong, Noel L Warner, Daniel H Fowler
Publikováno v:
PLoS Biology, Vol 8, Iss 2, p e1000302 (2010)
Immunotherapy using regulatory T cells (Treg) has been proposed, yet cellular and molecular mechanisms of human Tregs remain incompletely characterized. Here, we demonstrate that human Tregs promote the generation of myeloid dendritic cells (DC) with
Externí odkaz:
https://doaj.org/article/51447135cf054e8d9db8f38373ff2954