Výsledky vyhledávání

Akademický článek

HIV-1 vaccine-induced T-cell responses cluster in epitope hotspots that differ from those induced in natural infection with HIV-1.

Autor: Tomer Hertz, Hasan Ahmed, David P Friedrich, Danilo R Casimiro, Steven G Self, Lawrence Corey, M Juliana McElrath, Susan Buchbinder, Helen Horton, Nicole Frahm, Michael N Robertson, Barney S Graham, Peter Gilbert

Publikováno v: PLoS Pathogens, Vol 9, Iss 6, p e1003404 (2013)

Several recent large clinical trials evaluated HIV vaccine candidates that were based on recombinant adenovirus serotype 5 (rAd-5) vectors expressing HIV-derived antigens. These vaccines primarily elicited T-cell responses, which are known to be crit

Externí odkaz: https://doaj.org/article/65453933a1c548b5b4a92a58148c1113

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Akademický článek

Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study.

Autor: Fusheng Li, Adam C Finnefrock, Sheri A Dubey, Bette T M Korber, James Szinger, Suzanne Cole, M Juliana McElrath, John W Shiver, Danilo R Casimiro, Lawrence Corey, Steven G Self

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e20479 (2011)

T cell directed HIV vaccines are based upon the induction of CD8+ T cell memory responses that would be effective in inhibiting infection and subsequent replication of an infecting HIV-1 strain, a process that requires a match or near-match between t

Externí odkaz: https://doaj.org/article/f5a5c2cd74964d488c8390d72ef137c1

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Akademický článek

Equivalence of ELISpot assays demonstrated between major HIV network laboratories.

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14330 (2010)

The Comprehensive T Cell Vaccine Immune Monitoring Consortium (CTC-VIMC) was created to provide standardized immunogenicity monitoring services for HIV vaccine trials. The ex vivo interferon-gamma (IFN-γ) ELISpot is used extensively as a primary imm

Externí odkaz: https://doaj.org/article/d7ee610eb88e43178a1408e4a5529118

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Akademický článek

Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells.

Autor: Nathan P Corbett, Darren Blimkie, Kevin C Ho, Bing Cai, Darren P Sutherland, Arlene Kallos, Juliet Crabtree, Annie Rein-Weston, Pascal M Lavoie, Stuart E Turvey, Natalie R Hawkins, Steven G Self, Christopher B Wilson, Adeline M Hajjar, Edgardo S Fortuno, Tobias R Kollmann

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e15041 (2010)

Newborns and young infants suffer increased infectious morbidity and mortality as compared to older children and adults. Morbidity and mortality due to infection are highest during the first weeks of life, decreasing over several years. Furthermore,

Externí odkaz: https://doaj.org/article/f7561129a616468794da1ddc3981c4ab

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Akademický článek

Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa.

Autor: Laith J Abu-Raddad, Amalia S Magaret, Connie Celum, Anna Wald, Ira M Longini, Steven G Self, Lawrence Corey

Publikováno v: PLoS ONE, Vol 3, Iss 5, p e2230 (2008)

BackgroundExtensive evidence from observational studies suggests a role for genital herpes in the HIV epidemic. A number of herpes vaccines are under development and several trials of the efficacy of HSV-2 treatment with acyclovir in reducing HIV acq

Externí odkaz: https://doaj.org/article/d81916ece6794fffac6d86baa1573780

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Akademický článek

Direct inference of SNP heterozygosity rates and resolution of LOH detection.

Autor: Xiaohong Li, Steven G Self, Patricia C Galipeau, Thomas G Paulson, Brian J Reid

Publikováno v: PLoS Computational Biology, Vol 3, Iss 11, p e244 (2007)

Single nucleotide polymorphisms (SNPs) have been increasingly utilized to investigate somatic genetic abnormalities in premalignancy and cancer. LOH is a common alteration observed during cancer development, and SNP assays have been used to identify

Externí odkaz: https://doaj.org/article/425580a6c37447fa99dccd8a71786852

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Akademický článek

On modeling HIV and T cells in vivo: assessing causal estimators in vaccine trials.

Autor: W David Wick, Peter B Gilbert, Steven G Self

Publikováno v: PLoS Computational Biology, Vol 2, Iss 6, p e64 (2006)

The first efficacy trials--named STEP--of a T cell vaccine against HIV/AIDS began in 2004. The unprecedented structure of these trials raised new modeling and statistical challenges. Is it plausible that memory T cells, as opposed to antibodies, can

Externí odkaz: https://doaj.org/article/0aa5af28731845afbcf5cef995e51e49

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Characteristics of fine pores in some halloysites

Autor: R. J. Gilkes, T. J. Davy, Gordon Jock Churchman, L. A. G. Aylmore, P. G. Self

Publikováno v: Clay Minerals. 30:89-98

Isotherms were obtained for nitrogen adsorption and desorption on seven halloysite-rich samples from New Zealand and Western Australia. Calculations from these isotherms indicate that halloysites with mainly small particles (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::836bfe1c4b7175574b55585b13c77b94
https://doi.org/10.1180/claymin.1995.030.2.01

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