Zobrazeno 1 - 10
of 72
pro vyhledávání: '"P. G. Madonov"'
Publikováno v:
Сибирский научный медицинский журнал, Vol 44, Iss 5, Pp 138-144 (2024)
The widespread use of testicular hyaluronidase preparations determines the particular interest in the development of oral dosage form. The drug under development, which is hyaluronidase pegylated using electron beam immobilization technology (PEG-GIA
Externí odkaz:
https://doaj.org/article/17207d748e774ddab6989045097fbb6f
Publikováno v:
Российский офтальмологический журнал, Vol 16, Iss 4, Pp 113-121 (2023)
Purpose: to study the regenerative potential of immobilized hyaluronidase and subtilisin enzymes preparations in experimental models of chemical and mechanical corneal trauma.Material and methods. The study involved 28 mongrel rabbits weighing 3.5 to
Externí odkaz:
https://doaj.org/article/ae95edb8547a484492ff238fc2a3be41
Autor:
K. I. Ershov, A. M. Shvetsova, E. Yu. Sherstoboev, A. A. Churin, V. V. Zhdanov, M. A. Korolev, P. G. Madonov
Publikováno v:
Сибирский научный медицинский журнал, Vol 43, Iss 5, Pp 118-126 (2023)
The development of safe drugs occupies a special place in the pharmaceutical industry. One of the main tasks of its preclinical phase is to evaluate possible toxic effects of the developed drug on the body and on various systems, including the immune
Externí odkaz:
https://doaj.org/article/afc4df813e9042029a6cdddd535ea33a
Publikováno v:
Сибирский научный медицинский журнал, Vol 43, Iss 1, Pp 59-70 (2023)
The use of enzyme preparations is a traditional trend in various fields of medicine. The usage of immobilized enzymes hyaluronidase (IG) and subtilisin (IS) seems to be very promising for the treatment of damage to the ocular surface. The aim of the
Externí odkaz:
https://doaj.org/article/b7a9c350012849ff9c466c5d2713d627
Publikováno v:
Сибирский научный медицинский журнал, Vol 42, Iss 5, Pp 37-42 (2022)
The pharmacological experiments on isolated organs (ex vivo) are the preferred method for assessing the primary pharmacodynamics of the studied drugs, since this method is completely excluded the systemic influence of neurohumoral regulation. In the
Externí odkaz:
https://doaj.org/article/67df8c3a7e3e420da69b42bb42b09d1a
Autor:
N. A. Kikhtenko, N. A. Bondarenko, N. P. Bgatova, L. A. Oleynik, O. V. Poveshchenko, A. Zh. Fursova, P. G. Madonov
Publikováno v:
Безопасность и риск фармакотерапии, Vol 9, Iss 4, Pp 200-208 (2021)
Currently, there are no efficacious, all-purpose antiviral medicines for the treatment of ocular surface infections caused by viruses. At the same time, type III interferons demonstrate high potency for histological barriers, such as the conjunctiva.
Externí odkaz:
https://doaj.org/article/95492679dd1240b2ad09b411ed82eced
Publikováno v:
Сибирский научный медицинский журнал, Vol 41, Iss 5, Pp 31-36 (2021)
The aim of the study was to determine the efficacy of recombinant human interferon lambda 1 (IFN-λ1) against human adenovirus serotype 5 in a culture of human conjunctival cells Chang conjunctiva clone 1-5c-4. Material and methods. The study design
Externí odkaz:
https://doaj.org/article/8abf90bff5b045259a083149d80b72f5
Autor:
M. A. Korolev, L. N. Rachkovskaya, P. G. Madonov, A. V. Shurlyginа, E. E. Rachkovsky, A. Yu. Letyagin, V. I. Konenkov, A. A. Churin, T. Yu. Dubskaya, T. V. Vetoshkina, L. A. Sandrikina, T. I. Fomina, E. P. Fedorova
Publikováno v:
Сибирский научный медицинский журнал, Vol 40, Iss 5, Pp 46-52 (2020)
Research Institute of Clinical and Experimental Lymphology has developed an innovative drug based on a complex of lithium citrate, polymethylsiloxane and aluminum oxide (LOAP). Lithium-based drugs are effective in treating bipolar disorders. However,
Externí odkaz:
https://doaj.org/article/235e1f80e32342e3aefc3bdbe4712ac5
Publikováno v:
Сибирский научный медицинский журнал, Vol 40, Iss 4, Pp 11-19 (2020)
Corneal diseases are the fourth leading cause of blindness in the world, accounting for approximately 5 % of cases. Existing methods of treatment in more than 30 % of cases do not have a full therapeutic effect and when the process is stopped, they e
Externí odkaz:
https://doaj.org/article/26a1a90b9a9f4417925be31f49e6d486
Publikováno v:
Сибирский научный медицинский журнал, Vol 40, Iss 2, Pp 15-23 (2020)
Interferons are a group of protein molecules with a broad spectrum of effects on the human body. Interferon lambda (type III interferon) was discovered comparatively recently about 20 years ago and its action is still poorly understood. However, the
Externí odkaz:
https://doaj.org/article/5bc929943b2d486eb7192c879812c0a1