Zobrazeno 1 - 10
of 18
pro vyhledávání: '"P. G. Kasprzyk"'
Publikováno v:
Nutrients, Vol 15, Iss 17, p 3723 (2023)
Several studies utilizing Rhodiola rosea, which contains a complex mixture of phytochemicals, reported some positive drug-drug interaction (DDI) findings based on in vitro CYP450’s enzyme inhibition, MAO-A and MAO-B inhibition, and preclinical phar
Externí odkaz:
https://doaj.org/article/281c1e4911654a2a8301effff66d92b3
Autor:
Philip G. Kasprzyk, Christopher Vickery, Mingli Ye, Magdalena Sewastianik, Wei Gong, Sheng Ding, Margitta Dziwenka, Amy Mozingo, Kaiti Valm, Holly Schachner, Jing-Ke Weng
Publikováno v:
Nutrients, Vol 14, Iss 11, p 2330 (2022)
Bioactive phytochemicals such as salidroside have been studied to understand the beneficial effects of Rhodiola rosea, an herbaceous plant used in traditional medicine to increase energy and treat a variety of health issues. However, Rhodiola plants
Externí odkaz:
https://doaj.org/article/fcceaf5c5e6147b882d5043f7c60e231
Autor:
Florence Meyer-Losic, Simon P Newman, Joanna M Day, Michael J Reed, Philip G Kasprzyk, Atul Purohit, Paul A Foster
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80305 (2013)
Despite paclitxael's clinical success, treating hormone-refractory breast cancer remains challenging. Paclitaxel has a poor pharmacological profile, characterized by a low therapeutic index (TIX) caused by severe dose limiting toxicities, such as neu
Externí odkaz:
https://doaj.org/article/72fc20d8905647e1aed52f755a02a4f3
Publikováno v:
Breast Cancer Research and Treatment. 38:19-25
The performance of OLX-209 indicates it should enter phase I clinical testing. OLX-209 is a recombinant toxin targeting the erbB-2 oncoprotein. The design of OLX-209 takes advantage of improvements in immunotoxin technology to produce a molecule that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34abe51479ca83bc86084702c6e5a48a
https://doi.org/10.1007/bf01803780
https://doi.org/10.1007/bf01803780
Autor:
Yoram Reiter, Ulrich Brinkmann, Ira Pastan, Sun-Hee Jung, P. G. Kasprzyk, C. R. King, Byungkook Lee
Publikováno v:
Journal of Biological Chemistry. 269:18327-18331
e23(dsFv)-PE38KDEL is a recombinant immunotoxin composed of the Fv region of anti-erbB2 monoclonal antibody e23 connected to a truncated form of Pseudomonas exotoxin (PE38KDEL), in which the inherently unstable Fv heterodimer (composed of VH and VL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d18ce55b5f2cf988cb1fad93afd6a3fc
https://doi.org/10.1016/s0021-9258(17)32310-4
https://doi.org/10.1016/s0021-9258(17)32310-4
Autor:
P. H. Fischer, Janendra K. Batra, C. R. King, Ira Pastan, R. E. Bird, A. Kihara, P. G. Kasprzyk, N. A. Turner
Publikováno v:
Advances in Enzyme Regulation. 34:119-128
OLX-209 has readily measurable activity, is safe in experimental animals, and is efficacious in model systems. These results support the concept of OLX-209 and provide groundwork for further development of this oncoprotein targeted agent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46a9560c1848f5bd5245f4b1f9251d4
https://doi.org/10.1016/0065-2571(94)90012-4
https://doi.org/10.1016/0065-2571(94)90012-4
Publikováno v:
Proceedings of the National Academy of Sciences. 89:5867-5871
Immunotoxins were made using five different murine monoclonal antibodies to the human erbB2 gene product and LysPE40, a 40-kDa recombinant form of Pseudomonas exotoxin (PE) lacking its cell-binding domain. All five conjugates were specifically cytoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61ccc883b9be2a0cd54fe48878499ee
https://doi.org/10.1073/pnas.89.13.5867
https://doi.org/10.1073/pnas.89.13.5867
Publikováno v:
Anti-cancer agents in medicinal chemistry. 8(8)
The identification of a CDC25 inhibitor to arrest the cell cycle closely followed the discovery of CDC25 by Russell and Nurse in 1986. Recent advances at the preclinical and clinical stages reinforce the rationale to consider CDC25 as a relevant targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3a1a9e747770f9886b3c4807080352
https://pubmed.ncbi.nlm.nih.gov/19075568
https://pubmed.ncbi.nlm.nih.gov/19075568
Autor:
V, Papadopoulos, A, Kapsis, H, Li, H, Amri, M, Hardwick, M, Culty, P G, Kasprzyk, M, Carlson, J P, Moreau, K, Drieu
Publikováno v:
Anticancer research. 20(5A)
The peripheral-type benzodiazepine receptor (PBR) expression and localization correlate with human breast cancer cell proliferation and aggressive phenotype expression. The standardized extract of Ginkgo biloba leaves (EGb 761) and isolated ginkgolid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22e5ae92ff5e0a3967b75812cfcfc0c2
https://pubmed.ncbi.nlm.nih.gov/11062691
https://pubmed.ncbi.nlm.nih.gov/11062691
Autor:
P G, Kasprzyk, T L, Sullivan, J D, Hunt, C T, Gubish, C A, Scoppa, M, Oelkuct, R, Bird, P H, Fischer, J M, Siegfried, C R, King
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(1)
The recombinant oncotoxin OLX-209 [e23(Fv)PE38KDEL] has been developed to target cancers with erbB-2 expression and is nearing a clinical trial. Important in clinical planning is the selection of patients on the basis of tumor expression of erbB-2. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f1b3828faf02089333c7e0a805b348e
https://pubmed.ncbi.nlm.nih.gov/9816093
https://pubmed.ncbi.nlm.nih.gov/9816093