Zobrazeno 1 - 10
of 134
pro vyhledávání: '"P. G. Higgins"'
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT In Acinetobacter baumannii, resistance-nodulation-cell division (RND)-type efflux is a resistance mechanism of great importance since it contributes to reduced susceptibility to multiple antimicrobial compounds. Some mutations within the gen
Externí odkaz:
https://doaj.org/article/d4365da4f82344a39b9d63312fb12fff
Autor:
Frieder Fuchs, Kyriaki Xanthopoulou, Tessa Burgwinkel, Rocío Arazo del Pino, Esther Wohlfarth, Florian Pavlu, Ralf M. Hagen, Paul G. Higgins
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 39, Iss , Pp 184-188 (2024)
Objective: To molecularly characterize several extensively drug-resistant isolates from a single hospital admission screening of a war-injured patient from Ukraine. Methods: Admission screening included swabs from skin, wounds, catheters, nasopharyng
Externí odkaz:
https://doaj.org/article/07a1d2dc0c624313b8e07f951eafa8fb
Autor:
Aye Mya Sithu Shein, Dhammika Leshan Wannigama, Cameron Hurst, Peter N. Monk, Mohan Amarasiri, Thidathip Wongsurawat, Piroon Jenjaroenpun, Phatthranit Phattharapornjaroen, William Graham Fox Ditcham, Puey Ounjai, Thammakorn Saethang, Naphat Chantaravisoot, Vishnu Nayak Badavath, Sirirat Luk-in, Sumanee Nilgate, Ubolrat Rirerm, Sukrit Srisakul, Naris Kueakulpattana, Matchima Laowansiri, S. M. Ali Hosseini Rad, Supaporn Wacharapluesadee, Apaporn Rodpan, Natharin Ngamwongsatit, Arsa Thammahong, Hitoshi Ishikawa, Robin James Storer, Asada Leelahavanichkul, Naveen Kumar Devanga Ragupathi, Annika Y. Classen, Talerngsak Kanjanabuch, Daniel Pletzer, Kazuhiko Miyanaga, Longzhu Cui, Hiroshi Hamamoto, Paul G. Higgins, Anthony Kicic, Tanittha Chatsuwan, Parichart Hongsing, Shuichi Abe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract The increasing occurrence of hospital-associated infections, particularly bacteremia, caused by extensively drug-resistant (XDR) carbapenemase-producing colistin-resistant Klebsiella pneumoniae highlights a critical requirement to discover n
Externí odkaz:
https://doaj.org/article/ca32abaf642b4c4d8c0abc8a3029dd50
Autor:
Aye Mya Sithu Shein, Parichart Hongsing, Aisha Khatib, Phatthranit Phattharapornjaroen, Kazuhiko Miyanaga, Longzhu Cui, Kenji Shibuya, Mohan Amarasiri, Peter N. Monk, Anthony Kicic, Tanittha Chatsuwan, Paul G. Higgins, Shuichi Abe, Dhammika Leshan Wannigama
Publikováno v:
npj Antimicrobials and Resistance, Vol 2, Iss 1, Pp 1-19 (2024)
Abstract Persistent bacterial lung infections in children lead to significant morbidity and mortality due to antibiotic resistance. In this paper, we describe how phage therapy has shown remarkable efficacy in preclinical and clinical studies, demons
Externí odkaz:
https://doaj.org/article/2c3da4b045934d7fa38ac7ae6a5bb348
Autor:
Shuichi Abe, Dhammika Leshan Wannigama, Yu Suzuki, Daisuke Akaneya, Junko Igarashi, Mayu Suto, Kazunori Moriya, Daisuke Ishizawa, Yoshikazu Okuma, Parichart Hongsing, Cameron Hurst, Thammakorn Saethang, Paul G. Higgins, Stephen M. Stick, Anthony Kicic
Publikováno v:
New Microbes and New Infections, Vol 62, Iss , Pp 101522- (2024)
Background: Ensitrelvir, a 3C-like protease inhibitor, received emergency approval in Japan in November 2022 for treating non-hospitalized patients with mild-to-moderate COVID-19. However, confirmation of its real-world clinical effectiveness is limi
Externí odkaz:
https://doaj.org/article/12d7e4f1fe8d4df29dc97169a2f15310
Autor:
Cristina Pitart, Maria Piquet, Tessa Burgwinkel, Rocío Arazo Del Pino, Marc Rubio, Mireia Aguilar, Sergi De Gea, Andrea Pulgarín, Irene Campo, Blanca Torralbo, Romina Parejo, Silvia Valls, Isabel Fortes, Gemina Santana, Elisa Rubio, Anna Vilella, Ana Del Río, José Antonio Martínez, Elisenda Miró, Ferran Navarro, Mateu Espasa, Climent Casals-Pascual, Jordi Vila, Paul G. Higgins, Ignasi Roca
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Early detection of disseminating vancomycin-resistant Enterococcus faecium (VREfm) in ICU wards is crucial for outbreak identification and the implementation of prompt infection control measures. Genotypic methods like pulsed-field gel electrophoresi
Externí odkaz:
https://doaj.org/article/c2213ded677749769132546101590a36
Autor:
Frédéric Grenier, Vincent Baby, Sarah Allard, Simon Lévesque, François Papale, Richard Sullivan, Hannah L. Landecker, Paul G. Higgins, Sébastien Rodrigue, Louis-Patrick Haraoui
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 11 (2024)
ABSTRACT blaNDM, the most prevalent carbapenemase among carbapenem-resistant Enterobacteriaceae, is thought to have emerged in India, as its initial detection in 2008 was linked to this country, and subsequent retrospective surveys had so far establi
Externí odkaz:
https://doaj.org/article/8ec345d98fb04779b4ced6610b10fed6
Autor:
Dhammika Leshan Wannigama, Cameron Hurst, Phatthranit Phattharapornjaroen, Parichart Hongsing, Natchalaikorn Sirichumroonwit, Kanokpoj Chanpiwat, Ali Hosseini Rad S.M., Robin James Storer, Puey Ounjai, Phitsanuruk Kanthawee, Natharin Ngamwongsatit, Rosalyn Kupwiwat, Chaisit Kupwiwat, James Michael Brimson, Naveen Kumar Devanga Ragupathi, Somrat Charuluxananan, Asada Leelahavanichkul, Talerngsak Kanjanabuch, Paul G. Higgins, Vishnu Nayak Badavath, Mohan Amarasiri, Valerie Verhasselt, Anthony Kicic, Tanittha Chatsuwan, Kashif Pirzada, Farid Jalali, Angela M. Reiersen, Shuichi Abe, Hitoshi Ishikawa, Chanikan Tanasatitchai, Supamat Amphol, Ladda Nantawong, Prangrawee Sangchan, Varissara Sinkajarern, Thutpharritchn Phoonakh, Phornnapat Utenpattanun, Aye Mya Sithu Shein, Timporn Vitoonpong, Nichapha Chongthavonsatit, Yahya Mankong, Piyapong Chaichana, Jenjira Yaithet, Dumrongsak Pongprajak, Sukjai Traimuangpak, Gasit Saksirisampant, Phimonsiri Lamloeskittinon, Adam Adam Hamdy, Sinthu Sinthu Kosasih, Sirirat Sirirat Luk-in
Publikováno v:
EClinicalMedicine, Vol 70, Iss , Pp 102517- (2024)
Summary: Background: Repurposed drugs with host-directed antiviral and immunomodulatory properties have shown promise in the treatment of COVID-19, but few trials have studied combinations of these agents. The aim of this trial was to assess the effe
Externí odkaz:
https://doaj.org/article/e15e771ec305477682b24779932f0426
Autor:
Rebecca J. Harris, Maninder Heer, Mark D. Levasseur, Tyrell N. Cartwright, Bethany Weston, Jennifer L. Mitchell, Jonathan M. Coxhead, Luke Gaughan, Lisa Prendergast, Daniel Rico, Jonathan M. G. Higgins
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Histone modifications influence the recruitment of reader proteins to chromosomes to regulate events including transcription and cell division. The idea of a histone code, where combinations of modifications specify unique downstream functio
Externí odkaz:
https://doaj.org/article/7bc3ec07d76b40a6a92788fa320dd0b0
Autor:
Thomas Schwarzl, Andrea Keogh, Georgina Shaw, Aleksandar Krstic, Elizabeth Clayton, Desmond G. Higgins, Walter Kolch, Frank Barry
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-6 (2023)
Abstract Articular cartilage has only very limited regenerative capacities in humans. Tissue engineering techniques for cartilage damage repair are limited in the production of hyaline cartilage. Mesenchymal stem/stromal cells (MSCs) are multipotent
Externí odkaz:
https://doaj.org/article/7c94cce76ce645939115b06e167c47f5