Zobrazeno 1 - 10
of 43
pro vyhledávání: '"P. G. H. Byfield"'
Autor:
P. G. H. Byfield, Caroline J. Small, Paul D. Upton, K Meeran, Stephen R. Bloom, Mohammad A. Ghatei, Donal O'Shea
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 82:95-100
Adrenomedullin has been proposed to be a circulating hormone regulating systemic and pulmonary blood pressure. A potential therapeutic role in the management of pulmonary hypertension has been suggested based on animal studies, but the pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6879bc60d9d6fcda749879544873865
https://doi.org/10.1210/jcem.82.1.3656
https://doi.org/10.1210/jcem.82.1.3656
Autor:
David M. Smith, Rohit N. Kulkarni, Z.L. Wang, RM Wang, Stephen R. Bloom, Karen O. Akinsanya, Mohammad A. Ghatei, W M Bennet, P. G. H. Byfield
Publikováno v:
Endocrinology. 136:5155-5164
TRH immunoreactivity has been detected in the pancreas of man and rat and localized to the islets of Langerhans. We studied the effect of synthetic TRH and the related tripeptide pyroglutamyl-phenylalanyl-proline amide (EFP) on isolated perifused rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54162921b77dbd48a5fe0fd0ddc9409
https://doi.org/10.1210/endo.136.11.7588254
https://doi.org/10.1210/endo.136.11.7588254
Publikováno v:
European Journal of Biochemistry. 229:140-147
A synthetic peptide [TAP25, (T1aAPPAHGVT9S10APDT14RPAPGS20)T1bAPPA5b] corresponding to one repeat (T1a–S20) and five overlapping amino acids (T1b–A5b) of the MUC1 core protein served as an acceptor substrate for in vitro glycosylation. TAP25 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec2fea621288ad31a2e57b1daed1593
https://doi.org/10.1111/j.1432-1033.1995.0140l.x
https://doi.org/10.1111/j.1432-1033.1995.0140l.x
Publikováno v:
Biochemistry. 32:13949-13955
Synthetic peptides corresponding to portions of the wild-type and variant sequences of the human factor VII gamma-carboxyglutamic acid (Gla)-containing domain have been prepared by direct peptide synthesis using the Fmoc-based protection strategy. Pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25aa9199b8e48c99e739d729484e02e4
https://doi.org/10.1021/bi00213a026
https://doi.org/10.1021/bi00213a026
Autor:
Paul Purkiss, P. G. H. Byfield, Karen O. Akinsanya, David M. Smith, Ranjev Bhogal, Noboru Yanaihara, Mohammad A. Ghatei, Stephen R. Bloom, D. Wynick
Publikováno v:
Proceedings of the National Academy of Sciences. 90:4231-4235
Structure-activity studies demonstrate that galanin fragments 1-15 and 2-29 are fully active, whereas fragment 3-29 has been reported to be inactive, in a number of different in vivo models. M15, a chimeric peptide comprising galanin 1-13 and substan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b6a9852cd945cdf707c0eb25a04b70
https://doi.org/10.1073/pnas.90.9.4231
https://doi.org/10.1073/pnas.90.9.4231
Autor:
P. G. H. Byfield, Z.L. Wang, Mohammad A. Ghatei, W. M. Bennet, Stephen R. Bloom, David M. Smith
Publikováno v:
Diabetes. 42:330-335
IAPP, or amylin, is a 37-amino acid peptide that is co-secreted with insulin from the pancreatic β-cells. We have determined the effects of IAPP and the antagonist 8–37 fragment of IAPP on the secretion of insulin from isolated rat islets studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4654bacaa6010abea4b986d87d25320c
https://doi.org/10.2337/diab.42.2.330
https://doi.org/10.2337/diab.42.2.330
Publikováno v:
Biochemistry. 31:2805-2812
Factor VIII (FVIII) is the nonproteolytic cofactor for FIXa in the tenase complex of blood coagulation. FVIII is proteolytically activated by thrombin and FXa in vitro to form a heterotrimer with full procoagulant activity. Activated protein C inacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b870e55e241478c0577c98867f0d92
https://doi.org/10.1021/bi00125a022
https://doi.org/10.1021/bi00125a022
Publikováno v:
Nature. 396(6711)
Modification of histones, DNA-binding proteins found in chromatin, by addition of acetyl groups occurs to a greater degree when the histones are associated with transcriptionally active DNA1,2. A breakthrough in understanding how this acetylation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e075e62aa4d3ea766964e3a367afa3c4
https://pubmed.ncbi.nlm.nih.gov/9859997
https://pubmed.ncbi.nlm.nih.gov/9859997
Autor:
Rohit N. Kulkarni, P. G. H. Byfield, Stephen R. Bloom, W. M. Bennet, Mohammad A. Ghatei, RM Wang, David M. Smith, Z.L. Wang
Publikováno v:
The Journal of clinical investigation. 100(1)
Galanin mRNA and peptide are not detectable in normal islets. We studied the effect of galanin antagonists on insulin secretion in the rat beta cell line, RIN5AH, and in perifused rat islets. In RIN cell membranes galanin and its antagonists showed h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6d919f38a83a6dbebeca626ab3bffe
https://pubmed.ncbi.nlm.nih.gov/9202071
https://pubmed.ncbi.nlm.nih.gov/9202071
Autor:
P. G. H. Byfield, David M. Smith, G. M. Taylor, Mohammad A. Ghatei, Ali A. Owji, Stephen R. Bloom, K.A. Nandha
Publikováno v:
Regulatory peptides. 62(2-3)
The potent vasodilator peptide, adrenomedullin, has been shown to be present in plasma, suggesting a physiological role in cardiovascular control. Here we investigated the hypotensive action of adrenomedullin in vivo, using the anaesthetised rat as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9cc9aba203a6343d3dfe1cf407b29a
https://pubmed.ncbi.nlm.nih.gov/8795078
https://pubmed.ncbi.nlm.nih.gov/8795078