Zobrazeno 1 - 10 of 28 pro vyhledávání: '"P. G. Canonico"'
1
Broad-spectrum antiviral activity of 2-beta-D-ribofuranosylselenazole-4-carboxamide, a new antiviral agent
Autor: J J Kirsi, J A North, Byron K. Murray, P. G. Canonico, P C Srivastava, Roland K. Robins, P. A. Mckernan, John W. Huggins
Publikováno v: Antimicrobial Agents and Chemotherapy. 24:353-361
The relative in vitro antiviral activities of three related nucleoside carboxamides, ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), and selenazole (2-beta-D-ribofuranosylsel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7d750b658af9bcec072c493d143886
https://doi.org/10.1128/aac.24.3.353
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2
Synthesis and antiviral activity of certain carbamoylpyrrolopyrimidine and pyrazolopyrimidine nucleosides
Autor: P. G. Canonico, Roland K. Robins, Richard J. Goebel, Alexander D. Adams, P. A. Mckernan, Byron K. Murray, Ganapathi R. Revankar
Publikováno v: Journal of Medicinal Chemistry. 25:1334-1338
Following our recent discovery that 9-beta-D-ribofuranosylpurine-6-carboxamide (1) exhibits potent antiviral activity, we were prompted to synthesize certain pyrrolopyrimidine and pyrazolopyrimidine nucleosides containing a carbamoyl function (7a,b a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740a3aa5e03b02bf63a8e16ebb7c2d33
https://doi.org/10.1021/jm00353a012
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3
Effects of pneumococcal infection on rat liver microsomal enzymes and lipogenesis by isolated hepatocytes
Autor: J S Little, W L Rill, P G Canonico, E Ayala
Publikováno v: The American Journal of Clinical Nutrition. 30:1359-1363
Modification in the enzymatic complement and lipogenic functions of rat liver endoplasmic reticulum (ER) were shown to occur during pneumococcal sepsis. Glucose-6-phosphatase, 5'nucleotidase, esterase, and NADPH cytochrome C reductase decreased in ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b9712f903f650f969d3769c94f8d3a
https://doi.org/10.1093/ajcn/30.8.1359
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5
Phagocytosis of Francisella tularensis by Rhesus monkey peripheral leukocytes
Autor: R A Proctor, E Ayala, P G Canonico, J D White
Publikováno v: Infection and Immunity. 11:146-151
Phagocytosis of Francisella tularensis by rhesus monkey peripheral neutrophils (PMN, was assessed by autoradiography, electron microscopy, and biochemical techniques. PMN, in contrast to mononuclear phagocytes, were unable to phagocytize F. tularensi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba319acac99d0e030a62a4e5c8f00577
https://doi.org/10.1128/iai.11.1.146-151.1975
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6
Synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides
Autor: P. G. Canonico, Roland K. Robins, P. A. Mckernan, P. K. Gupta, G. R. Revankar, N. K. Dalley, A. D. Adams, P. D. Cook
Publikováno v: Journal of Medicinal Chemistry. 27:1389-1396
A new procedure for the preparation of the antiviral and antitumor agent 3-deazaguanine (1) and its metabolite 3-deazaguanosine (2) has been developed by reacting methyl 5(4)-(cyanomethyl) imidazole-4(5)-carboxylate (4) and 5-(cyanomethyl)-1- (2,3,5-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41806912f8ba3cf9ddc2f17743753bea
https://doi.org/10.1021/jm00377a002
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7
Synthesis and biological activity of 5-thiobredinin and certain related 5-substituted imidazole-4-carboxamide ribonucleosides
Autor: P. G. Canonico, K. G. Upadhya, S. G. Wood, G. R. Revankar, N. K. Dalley, Roland K. Robins, P. A. Mckernan
Publikováno v: Journal of Medicinal Chemistry. 28:1198-1203
A number of 5-substituted imidazole-4-carboxamide ribonucleosides were prepared and tested for their biological activity. Treatment of 5-chloro-1-beta-D-ribofuranosylimidazole-4-carboxamide (2) with methanethiol provided 5-(methylthio)-1-beta-D-ribof
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a891e703c403f5a416b3504e16c908
https://doi.org/10.1021/jm00147a013
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8
Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses
Autor: P. G. Canonico, Roland K. Robins, John W. Huggins
Publikováno v: Antimicrobial Agents and Chemotherapy. 26:476-480
Binary combinations of the N-nucleoside ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) and the C-nucleoside analog selenazofurin (2-beta-D-ribofuranosylselenazole-4-carboxamide) or tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9093e46a9fb0754270411a269817736c
https://doi.org/10.1128/aac.26.4.476
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9
Antibody response to Rocky Mountain spotted fever
Autor: Lauren R. Bagley, Richard H. Kenyon, L S Sammons, P G Canonico, Carl E. Pedersen
Publikováno v: Journal of Clinical Microbiology. 3:513-518
Various techniques were compared to determine the most sensitive method for detection of rocky Mountain spotted fever antibody. A radiometabolic technique for detection of Rocky Mountain spotted fever antibody is also described. In infected monkeys,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddf26df5f1d07e75ff0a50c19efc9e2
https://doi.org/10.1128/jcm.3.5.513-518.1976
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