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Akademický článek

Clinical covariates that improve the description of high dose methotrexate pharmacokinetics in a diverse population to inform MTXPK.org

Autor: Zachary L. Taylor, Tamara P. Miller, Ethan A. Poweleit, Nicholas P. DeGroote, Lauren Pommert, Oluwafunbi Awoniyi, Sarah G. Board, Ngozi Ugboh, Vivek Joshi, Nick Ambrosino, Ashley Chavana, Melanie B. Bernhardt, Eric S. Schafer, Maureen M. O'Brien, Sharon M. Castellino, Laura B. Ramsey

Publikováno v: Clinical and Translational Science, Vol 16, Iss 11, Pp 2130-2143 (2023)

Abstract The MTXPK.org webtool was launched in December 2019 and was developed to facilitate model‐informed supportive care and optimal use of glucarpidase following the administration of high‐dose methotrexate (HDMTX). One limitation identified

Externí odkaz: https://doaj.org/article/5f03661676c74213b95f1b9c76080e52

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Akademický článek

Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of a non-catalytic ligandin site.

Autor: Joseph Brock, Philip G Board, Aaron J Oakley

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e60324 (2013)

Glutathione transferases (GSTs) are dimeric enzymes containing one active-site per monomer. The omega-class GSTs (hGSTO1-1 and hGSTO2-2 in humans) are homodimeric and carry out a range of reactions including the glutathione-dependant reduction of a r

Externí odkaz: https://doaj.org/article/1e81778efc344752af6c13c8ddd1ebd2

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Efavirenz as a potential drug for the treatment of triple-negative breast cancers

Autor: P-T, Chiou, S, Ohms, P G, Board, J E, Dahlstrom, D, Rangasamy, M G, Casarotto

Publikováno v: Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 23(2)

In contrast to hormone receptor driven breast cancer, patients presenting with triple-negative breast cancer (TNBC) often have limited drug treatment options. Efavirenz, a non-nucleoside reverse transcriptase (RT) inhibitor targets abnormally overexp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3e70faf37541a26ae1ca376e8a9b42d
https://pubmed.ncbi.nlm.nih.gov/32566961

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Levels of expression of the mdr1 gene and glutathione S-transferase genes 2 and 3 and response to chemotherapy in multiple myeloma

Autor: P. G. Board, J. P. Matthews, D. M. Woodcock, M. E. Linsenmeyer, S. Jefferson, M. Wolf

Publikováno v: British Journal of Cancer

We have quantitated the levels of mRNAs in bone marrow samples from patients with multiple myeloma of the mdr1 gene (responsible for the Multidrug Resistance phenotype) and for two of the glutathione S-transferase gene, GST-2 and GST-3 (which can als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e56da593e1682b833298292166bcb3f
http://europepmc.org/articles/PMC1977615

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Expression of Functional Coagulation Factor XIII in Escherichia coli

Autor: P G Board, Coggan M, Kerrie D. Pierce

Publikováno v: Scopus-Elsevier

SummaryCoagulation factor XIII is a zymogen that can be activated by thrombin cleavage to a transglutaminase that catalyses the formation of covalent crosslinks between fibrin chains in the final stages of the blood clotting cascade. Although circula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c8dd75b9b842965ef0eeb6b57a2968
https://doi.org/10.1055/s-0038-1645201

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Dichloromethane mediated in vivo selection and functional characterization of rat glutathione S-transferase theta 1-1 variants

Autor: D, Gisi, J, Maillard, J U, Flanagan, J, Rossjohn, G, Chelvanayagam, P G, Board, M W, Parker, T, Leisinger, S, Vuilleumier

Publikováno v: European journal of biochemistry. 268(14)

Methylobacterium dichloromethanicum DM4 is able to grow with dichloromethane as the sole carbon and energy source by using a dichloromethane dehalogenase/glutathione S-transferase (GST) for the conversion of dichloromethane to formaldehyde. Mammalian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b521e894ab185cb75ee340cea6a529b
https://pubmed.ncbi.nlm.nih.gov/11453994

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Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases

Autor: A M, Caccuri, G, Antonini, P G, Board, M W, Parker, M, Nicotra, M, Lo Bello, G, Federici, G, Ricci

Potentiometric, spectroscopic and stopped-flow experiments have been performed to dissect the binding mechanism of GSH to selected glutathione S-transferases (GSTs), A1-1, M2-2 and Lucilia cuprina GST, belonging to Alpha, Mu and Delta classes respect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7912828e35cf472085b2e49c53263343
http://hdl.handle.net/2108/69132

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