Výsledky vyhledávání - "P. F. Von Voigtlander"

Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3-propyl-1H-benz[e]indole-9-carboxamide: A potent and selective 5-HT1A receptor agonist with good oral availability

Autor: Robert B. McCall, G. Phillips, Chiu-Hong Lin, C. G. Chidester, Montford F. Piercey, Kjell A. Svensson, M. W. Smith, Susanne R. Haadsma-Svensson, P. F. Von Voigtlander, Arvid Carlsson

Publikováno v: Journal of Medicinal Chemistry. 36:2208-2218

The synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b- hexahydro-3-propyl-1H-benz[e]indole-9-carboxamide ((-)-3a), U93385, is described. The cis racemate and its enantiomer as well as the corresponding trans enantiomers were also synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d36e0beb2ab84b15d7a18c18bf89062
https://doi.org/10.1021/jm00067a018

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Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives

Autor: Chiu-Hong Lin, Montford F. Piercey, Robert B. McCall, G. Phillips, P. F. Von Voigtlander, Robert A. Lahti, M. W. Smith, Susanne R. Haadsma-Svensson, P. J. K. D. Schreur, C. G. Chidester

Publikováno v: Journal of Medicinal Chemistry. 36:1069-1083

The conformationally restricted linear tricyclic analogs of 5- and 8-hydroxy-2-(di-n-propylamino)-tetralins were investigated for their serotonergic and dopaminergic properties. These cis and trans analogs of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0e3cef633462f8fec4b8202908241e
https://doi.org/10.1021/jm00060a015

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Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives

Autor: C H, Lin, S R, Haadsma-Svensson, R A, Lahti, R B, McCall, M F, Piercey, P J, Schreur, P F, Von Voigtlander, M W, Smith, C G, Chidester

Publikováno v: Journal of Medicinal Chemistry. 36:1053-1068

The synthesis and structure-activity relationships (SAR) of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives (3) are described. These compounds are conformationally restricted, angular tricyclic analogs of 2-aminotetralin. The synthesis was achie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915eed22f4246a6b69375ea3c44c52a9
https://doi.org/10.1021/jm00060a014

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Anxiolytic-like effects of PNU-101017, a partial agonist at the benzodiazepine receptor

Autor: L. M. Needham, P. F. Von Voigtlander, E. J. Jacobsen, Donald B. Carter, V. H. Sethy, S. R. Franklin, Andrew H. Tang

Publikováno v: Psychopharmacology. 131(3)

PNU-101017 is a chemically novel ligand at the benzodiazepine recognition site of cloned GABAA receptors. It was reported to potentiate GABA-mediated chloride current in cultured cells with a moderate intrinsic activity and a biphasic dose-response r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b57b807187dff9a50fac8487d6bf7a
https://pubmed.ncbi.nlm.nih.gov/9203236

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Protective effects of tirilazad mesylate in a cellular model of peroxynitrite toxicity

Autor: G J, Fici, J S, Althaus, E D, Hall, P F, Von Voigtlander

Publikováno v: Research communications in molecular pathology and pharmacology. 91(3)

Following CNS trauma or ischemia, peroxynitrite may be a toxic intermediate which forms in vivo when nitric oxide condenses with superoxide. Alone, peroxynitrite appears to directly react with aromatic and sulfhydryl nucleophiles. However, at physiol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4d37bfc5acfe56c64b2e63a8fa92f96
https://pubmed.ncbi.nlm.nih.gov/8829775

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Kappa agonist-induced reduction in dopamine release: site of action and tolerance

Autor: B A, Donzanti, J S, Althaus, M M, Payson, P F, Von Voigtlander

Publikováno v: Research communications in chemical pathology and pharmacology. 78(2)

Kappa opioid agonists are known to inhibit dopamine release. We sought to determine the site of this action and the relationship of tolerance to this effect. Microdialysis perfusion of the nucleus accumbens in unanesthetized rats was used to monitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5945919c740df3e63d60233b24817f8e
https://pubmed.ncbi.nlm.nih.gov/1282270

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Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds

Autor: M W, Moon, J K, Morris, R F, Heier, C G, Chidester, W E, Hoffmann, M F, Piercey, J S, Althaus, P F, Von Voigtlander, D L, Evans, L M, Figur

Publikováno v: Journal of medicinal chemistry. 35(6)

The synthesis of 5-(dipropylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij] quinolin-2(1H)-one (5), a potent dopamine D2 agonist showing high dopamine/serotonin (5HT1A) selectivity, is described. Dopaminergic activity is associated with the (R)-enantiomer of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6209ac10169732f76179fab0fd972ef
https://pubmed.ncbi.nlm.nih.gov/1348089

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