Zobrazeno 1 - 10
of 15
pro vyhledávání: '"P. F. Speake"'
Publikováno v:
Placenta. 31:289-294
Na(+)/H(+) exchanger (NHE) activity regulates intracellular pH (pH(i)) in the placental syncytiotrophoblast. In other tissues aldosterone and cortisol have been shown to up-regulate NHE activity via an acute, non-genomic effect. Here we tested the hy
Autor:
Paul T.-Y. Ayuk, Jocelyn D. Glazier, P. F. Speake, Stephen W D'Souza, Colin P. Sibley, Michael C. Reade
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 88:4287-4292
Cord blood levels of nitrate/nitrite, as a measure of nitric oxide (NO), are generally increased in preeclampsia. As L-arginine is the precursor for NO synthesis, we hypothesized that L-arginine transport across the syncytiotrophoblast basal plasma m
Autor:
J. S. Gibson, P. F. Speake
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 434:104-112
The effect of urea and its interactions with oxygen tension (PO2), cell volume and inhibitors of protein phosphatases/kinases (PP/PK) on the K influx into equine red blood cells were studied. K influx was measured using 86Rb as a radioactive tracer f
Autor:
Stephen W D'Souza, Philip N. Baker, Jocelyn D. Glazier, C.P. Sibley, W. Fergusson, C. G. Iruloh, P. F. Speake, Ian P. Crocker
Publikováno v:
American journal of physiology. Cell physiology. 292(1)
Transplacental transfer of taurine, a β-amino acid essential for fetal and neonatal development, constitutes the primary source of taurine for the fetus. Placental transport of taurine is compromised in pregnancies complicated by intrauterine growth
Autor:
Susan L. Greenwood, P. F. Speake, K. J. Mynett, M. Desforges, C.P. Sibley, H. A. Lacey, Jocelyn D. Glazier
Publikováno v:
American journal of physiology. Cell physiology. 290(1)
The system A amino acid transporter is encoded by three members of the Slc38 gene family, giving rise to three subtypes: Na+-coupled neutral amino acid transporter (SNAT)1, SNAT2, and SNAT4. SNAT2 is expressed ubiquitously in mammalian tissues; SNAT1
Publikováno v:
Pflugers Archiv : European journal of physiology. 450(2)
The purpose of this study was to compare Na+/H+ exchanger (NHE) activity in the microvillous (MVM) and basal (BM) plasma membrane of the human placental syncytiotrophoblast and to determine the relative contribution of various NHE isoforms to this ac
Publikováno v:
Journal of the Society for Gynecologic Investigation. 11(7)
Pregnant women undergoing long-term organ transplant treatment have an increased incidence of delivering infants with intrauterine growth restriction (IUGR). Cyclosporine A is used as an immunosuppressant in such women and indirect evidence suggests
Autor:
E. E. Champion, Jocelyn D. Glazier, I.M. Doughty, Colin P. Sibley, Settle P, Stephen W D'Souza, P. F. Speake, K. J. Mynett
Publikováno v:
Placenta. 25(6)
We investigated the polarization of l-lactate transport in human syncytiotrophoblast by measuring uptake of [(14)C] l-lactate by both microvillous (maternal-facing; MVM) and basal (fetal-facing; BM) plasma membranes. [(14)C] l-lactate uptake by MVM a
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(3)
The molecular basis of sickle cell disease (SCD) is well known but the pathophysiology is poorly understood. It remains intractable to therapy. Hyperactivity of several membrane transport systems, including the K+-Cl- cotransporter (termed KCC), caus
Publikováno v:
American journal of physiology. Cell physiology. 279(4)
The effect of oxidants on K+-Cl−cotransport (KCC) was investigated in equine red blood cells. Carbon monoxide mimicked O2. The substituted benzaldehyde, 12C79 (5 mM), markedly increased O2affinity. In N2, however, O2saturation was low (2−) oxidiz