Zobrazeno 1 - 10
of 37
pro vyhledávání: '"P. F. Nolan"'
Autor:
Harry Clark, Matthew F Nolan
Publikováno v:
eLife, Vol 12 (2024)
Grid firing fields have been proposed as a neural substrate for spatial localisation in general or for path integration in particular. To distinguish these possibilities, we investigate firing of grid and non-grid cells in the mouse medial entorhinal
Externí odkaz:
https://doaj.org/article/b7876e6686974207988c7cbe47001d5c
Publikováno v:
BMC Psychiatry, Vol 21, Iss 1, Pp 1-7 (2021)
Abstract Background A key component of caring for service users (SUs) in acute mental health inpatient environments is Therapeutic Engagement (TE). To that end, the Therapeutic Engagement Questionnaire (TEQ) was developed and validated. The TEQ measu
Externí odkaz:
https://doaj.org/article/b47b401e86514a09b71d98b9ef74b00a
Publikováno v:
eLife, Vol 11 (2022)
Standard models for spatial and episodic memory suggest that the lateral entorhinal cortex (LEC) and medial entorhinal cortex (MEC) send parallel independent inputs to the hippocampus, each carrying different types of information. Here, we evaluate t
Externí odkaz:
https://doaj.org/article/48f89fb98f6d4d27ab12da392ddd621f
Publikováno v:
Advanced Science, Vol 9, Iss 31, Pp n/a-n/a (2022)
Abstract Establishing the biological basis of cognition and its disorders will require high precision spatiotemporal measurements of neural activity. Recently developed genetically encoded voltage indicators (GEVIs) report both spiking and subthresho
Externí odkaz:
https://doaj.org/article/61468b3376d34d3e987dac365b4e3824
Autor:
Klara Gerlei, Jessica Passlack, Ian Hawes, Brianna Vandrey, Holly Stevens, Ioannis Papastathopoulos, Matthew F. Nolan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Neurons with grid firing fields are thought to play important roles in spatial cognition. Here, the authors show that in contrast to assumptions underlying current models and analyses, grid fields are modulated by local head direction; this suggests
Externí odkaz:
https://doaj.org/article/a15ae37efc504133ae0a621f75797131
Publikováno v:
eLife, Vol 9 (2020)
Distinctions between cell types underpin organizational principles for nervous system function. Functional variation also exists between neurons of the same type. This is exemplified by correspondence between grid cell spatial scales and the synaptic
Externí odkaz:
https://doaj.org/article/4ddfa80c75104241b99542e9cb9b6f41
Autor:
Derek L.F. Garden, Marlies Oostland, Marta Jelitai, Arianna Rinaldi, Ian Duguid, Matthew F. Nolan
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1722-1733 (2018)
Summary: Cerebellar climbing-fiber-mediated complex spikes originate from neurons in the inferior olive (IO), are critical for motor coordination, and are central to theories of cerebellar learning. Hyperpolarization-activated cyclic-nucleotide-gated
Externí odkaz:
https://doaj.org/article/25fafbe1d8a044faafa108b140159741
Autor:
Sarah A. Tennant, Lukas Fischer, Derek L.F. Garden, Klára Zsófia Gerlei, Cristina Martinez-Gonzalez, Christina McClure, Emma R. Wood, Matthew F. Nolan
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1313-1324 (2018)
Summary: Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns of neurons in the superficial medial entorhinal cortex (MEC) suggest roles in behavioral
Externí odkaz:
https://doaj.org/article/58b0da70d1634651851d8b7edd600030
Publikováno v:
eLife, Vol 5 (2016)
Encoding of behavioral episodes as spike sequences during hippocampal theta oscillations provides a neural substrate for computations on events extended across time and space. However, the mechanisms underlying the numerous and diverse experimentally
Externí odkaz:
https://doaj.org/article/5e4d7b5b90764430a0bc3ae5b752a641
Publikováno v:
eLife, Vol 4 (2015)
Neural computations underlying cognitive functions require calibration of the strength of excitatory and inhibitory synaptic connections and are associated with modulation of gamma frequency oscillations in network activity. However, principles relat
Externí odkaz:
https://doaj.org/article/5fd3429ace9f47889cec8467fc0601b8