Zobrazeno 1 - 10
of 87
pro vyhledávání: '"P. F. Miles"'
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Ethanol’s anxiolytic actions contribute to increased consumption and the development of Alcohol Use Disorder (AUD). Our laboratory previously identified genetic loci contributing to the anxiolytic-like properties of ethanol in BXD recombinant inbre
Externí odkaz:
https://doaj.org/article/eceff5a414db4ab5a69c1f3baa44d923
Autor:
Stephen F. Woodford, Laurence Weinberg, Lachlan F. Miles, Ruth C. Marshall, Bernhard Riedel, Philip J. Peyton
Publikováno v:
Frontiers in Anesthesiology, Vol 3 (2024)
IntroductionEnsuring hemodynamic stability with adequate perfusion to vital organs is critical to the safe conduct of anesthesia. Recent advances in hemodynamic monitoring technologies allow pressure, flow, and resistance to be measured continuously;
Externí odkaz:
https://doaj.org/article/19ebe60b330c4722bcf2720cf76b3f26
Autor:
Jyoti Lodha, Emily R. Brocato, McKenzie Nash, Madison M. Marcus, A. Chris Pais, Alex B. Pais, Michael F. Miles, Jennifer Theresa Wolstenholme
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionAdolescence is a critical period in cognitive and emotional development, characterized by high levels of social interaction and increases in risk-taking behavior including binge drinking. Adolescent exposure to social stress and binge eth
Externí odkaz:
https://doaj.org/article/7549bd6df65143c79480223c1f931d2a
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 6, Pp 2637-2649 (2022)
Abstract Iron is an essential nutrient for oxygen supply and aerobic metabolism. Iron deficiency impacts cellular respiration and mitochondrial energy metabolism, which can lead to reduced skeletal muscle function and muscle mass, causing sarcopenia.
Externí odkaz:
https://doaj.org/article/6bc09572b2254878973381446225f178
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 343-354 (2022)
Adeno-associated virus serotype 9 (AAV9) is a promising gene therapy vector for treating neurodegenerative diseases due to its ability to penetrate the blood-brain barrier. PHP.eB was engineered from AAV9 by insertion of a 7-amino acid peptide and po
Externí odkaz:
https://doaj.org/article/df4fd9859c1b4dfeae3dfa8b780af72e
Autor:
Lachlan F. Miles, Vanessa Pac Soo, Sabine Braat, Stephane Heritier, Kate L. Burbury, David A. Story
Publikováno v:
Perioperative Medicine, Vol 11, Iss 1, Pp 1-8 (2022)
Abstract Background Pre-operative anaemia has been associated independently with worse outcomes after cardiac surgery in adults and is often caused by absolute or functional iron deficiency. Iron deficiency is a continuum ending with anaemia, and the
Externí odkaz:
https://doaj.org/article/b302dc5cb93444cca3cb643736078c76
Autor:
Amanda Elswick Gentry, Jeffry C Alexander, Mohammad Ahangari, Roseann E Peterson, Michael F Miles, Jill C Bettinger, Andrew G Davies, Mike Groteweil, Silviu A Bacanu, Kenneth S Kendler, Brien P Riley, Bradley T Webb, VCU Alcohol Research Center working group
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283985 (2023)
BackgroundVariation in genes involved in ethanol metabolism has been shown to influence risk for alcohol dependence (AD) including protective loss of function alleles in ethanol metabolizing genes. We therefore hypothesized that people with severe AD
Externí odkaz:
https://doaj.org/article/394282ea606b423584f7c03fb6230934
Autor:
Yu Hao Zeng, MD, Alexander Calderone, MD, Nicolas Rousseau-Saine, MD, FRCPC, Mahsa Elmi-Sarabi, PhD, Stéphanie Jarry, MSc, Étienne J. Couture, MD, FRCPC, Matthew P. Aldred, MBBS, FANZCA, Jean-Francois Dorval, MD, FRCPC, Yoan Lamarche, MD, MSc, FRCSC, Lachlan F. Miles, MBBS, PhD, FANZCA, William Beaubien-Souligny, MD, PhD, FRCPC, André Y. Denault, MD, PhD, FRCPC
Publikováno v:
CJC Open, Vol 3, Iss 9, Pp 1153-1168 (2021)
Background: Right ventricular outflow tract obstruction (RVOTO) is a cause of hemodynamic instability that can occur in several situations, including cardiac surgery, lung transplantation, and thoracic surgery, and in critically ill patients. The tim
Externí odkaz:
https://doaj.org/article/64d21f7060fa42c6af1e21fa12972b35
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Despite the increasing use of RNAseq for transcriptome analysis, microarrays remain a widely-used methodology for genomic studies. The latest generation of Affymetrix/Thermo-Fisher microarrays, the ClariomD/XTA and ClariomS array,
Externí odkaz:
https://doaj.org/article/b25664a052ee4accbdb0c94ac21d1812
Publikováno v:
BMJ Open, Vol 12, Iss 4 (2022)
Introduction Preoperative anaemia is associated with poor postoperative outcomes and is the strongest predictor of allogenic blood transfusion, which contributes further to patient morbidity. Emphasis has been placed on correcting anaemia prior to su
Externí odkaz:
https://doaj.org/article/48054727f00c433e80bf4f4b5f4a100f