Zobrazeno 1 - 10
of 12
pro vyhledávání: '"P. F. Langley"'
Publikováno v:
Xenobiotica. 10:761-769
1. The absorption of the phenol moiety of [phenol-14C]carfecillin following oral administration to rat, dog and man was extensive, since 95%, 73% and 99% of the administered radioactivity respectively was recovered in the urine. In contrast, less tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3d9726bd7895cdb5e6e950af9fde84
https://doi.org/10.3109/00498258009033804
https://doi.org/10.3109/00498258009033804
Publikováno v:
European Journal of Clinical Pharmacology. 23:167-172
The excretion of radioactivity has been investigated in 3 healthy volunteers following rapid intravenous administration of 5 g of [35S]-ticarcillin. The radioactive dose was rapidly and completely excreted, since within 4 days 98.5% was recovered, 95
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e27c747867abbd9adb009d9664131d2
https://doi.org/10.1007/bf00545973
https://doi.org/10.1007/bf00545973
Publikováno v:
Xenobiotica. 4:165-174
1. Chloroform (60 mg/kg), administered orally in olive oil to male and female mice of the CF/LF, CBA and C57 Black Strains, was metabolized to CO2 to an extent of 80%, the remainder being unchanged.2. The general pattern of distribution of chloroform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23d03d39393139e82da91afb65d3c73b
https://doi.org/10.3109/00498257409049356
https://doi.org/10.3109/00498257409049356
Publikováno v:
Xenobiotica. 4:151-163
1. The metabolism of [14C]chloroform by the mouse, rat and monkey has been investigated. A pronounced species variation was observed.2. In all three strains of mice examined about 80% of a dose of 60 mg/kg 14CHCl3 was converted to 14CO2. In the rat a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8153da1d4898c8eaea7827f90a845e34
https://doi.org/10.3109/00498257409049355
https://doi.org/10.3109/00498257409049355
Publikováno v:
Journal of Pharmacy and Pharmacology. 15:100-106
A spectrophotometric method is described for the quantitative determination of the quaternary ammonium compound, poldine methyl methosulphate in aqueous solution and in biological fluids. The method involves coupling with methyl orange with simultane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89d3e6203105a8aa84bb2f22beefa97
https://doi.org/10.1111/j.2042-7158.1963.tb12753.x
https://doi.org/10.1111/j.2042-7158.1963.tb12753.x
Publikováno v:
Biochemical Pharmacology. 15:1821-1829
Spectrophotometric assays indicated that following repeated daily oral dosage, 70 per cent of the poldine methyl methosulphate or its metabolites was excreted in the faeces, while 14 C-poldine methyl methiodide experiments showed significant biliary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::881a39407fc4fd0f39e0dcd93b06235f
https://doi.org/10.1016/0006-2952(66)90089-x
https://doi.org/10.1016/0006-2952(66)90089-x
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 10(10)
1. Studies have shown that hydrolysis of carfecillin to carbenicillin and phenol in vitro occurs in blood, liver and gut tissues of rat and dog. Extremely rapid hydrolysis was observed in the blood and liver of the rat. 2. Absorption studies in intes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2a238502499f7b2a1328070ce874aa
https://pubmed.ncbi.nlm.nih.gov/7456492
https://pubmed.ncbi.nlm.nih.gov/7456492
Publikováno v:
Chemotherapy. 24(4)
Talampicillin is an ester of ampicillin which is readily hydrolysed on absorption to release ampicillin. It is well absorbed from the gastro-intestinal tract resulting in a greater bioavailiability of ampicillin than can be achieved with equivalent d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8df8fd8fd0e067198db702ab413cee1
https://pubmed.ncbi.nlm.nih.gov/348415
https://pubmed.ncbi.nlm.nih.gov/348415
Publikováno v:
Pharmacology of Antibiotics ISBN: 9781468431254
Talampicillin (phthalidyl D-α-aminobenzylpenicillinate) is hydrolysed in the body to ampicillin. Although ampicillin is well absorbed, Talampicillin is even better absorbed, as shown by Human volunteer studies. In cross-over studies using a capsule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aed06ceb0a8447b47fd2a9b710d8431
https://doi.org/10.1007/978-1-4684-3123-0_33
https://doi.org/10.1007/978-1-4684-3123-0_33
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 8(7)
1. After administration of [phthalidyl-14C] talampicillin (Talpen) to rat, dog and man, radioactivity was excreted mainly in the urine (90%, 86% and 98% in rat, dog and man respectively). 2. After administration of [ampicillin-14C] talampicillin, rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e257e1bfe3f4bbf09452deae087104f
https://pubmed.ncbi.nlm.nih.gov/685291
https://pubmed.ncbi.nlm.nih.gov/685291