Zobrazeno 1 - 10
of 252
pro vyhledávání: '"P. F. Joyce"'
Autor:
Milad Mokhtaridoost, Jordan J. Chalmers, Marzieh Soleimanpoor, Brandon J. McMurray, Daniella F. Lato, Son C. Nguyen, Viktoria Musienko, Joshua O. Nash, Sergio Espeso-Gil, Sameen Ahmed, Kate Delfosse, Jared W. L. Browning, A. Rasim Barutcu, Michael D. Wilson, Thomas Liehr, Adam Shlien, Samin Aref, Eric F. Joyce, Anja Weise, Philipp G. Maass
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Non-homologous chromosomal contacts (NHCCs) between different chromosomes participate considerably in gene and genome regulation. Due to analytical challenges, NHCCs are currently considered as singular, stochastic events, and their extent a
Externí odkaz:
https://doaj.org/article/ac9565cd1a404b17b3b13e344b9a0a2f
Autor:
Li-Hsin Chang, Sourav Ghosh, Andrea Papale, Jennifer M. Luppino, Mélanie Miranda, Vincent Piras, Jéril Degrouard, Joanne Edouard, Mallory Poncelet, Nathan Lecouvreur, Sébastien Bloyer, Amélie Leforestier, Eric F. Joyce, David Holcman, Daan Noordermeer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Topologically Associating Domains (TADs) separate vertebrate genomes into insulated regulatory neighborhoods that focus genome-associated processes. TADs are formed by Cohesin-mediated loop extrusion, with many TAD boundaries consisting of c
Externí odkaz:
https://doaj.org/article/d7ed2d10c49f4258b3c6387c6f687e4e
Autor:
Parisha P. Shah, Kathleen C. Keough, Ketrin Gjoni, Garrett T. Santini, Richard J. Abdill, Nadeera M. Wickramasinghe, Carolyn E. Dundes, Ashley Karnay, Angela Chen, Rachel E. A. Salomon, Patrick J. Walsh, Son C. Nguyen, Sean Whalen, Eric F. Joyce, Kyle M. Loh, Nicole Dubois, Katherine S. Pollard, Rajan Jain
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-35 (2023)
Abstract Background Association of chromatin with lamin proteins at the nuclear periphery has emerged as a potential mechanism to coordinate cell type-specific gene expression and maintain cellular identity via gene silencing. Unlike many histone mod
Externí odkaz:
https://doaj.org/article/3460c0bf62da40d5bb6ad6b6c60d65c4
Autor:
Charles M M Peeters, Joshua M Bonsel, Roelina Munnik-Hagewoud, Adriaan K Mostert, Guido B van Solinge, Joost P H J Rutges, Mark C Altena, Paul F M Krabbe, G J F Joyce Bos, Chris Faber, Frits-Hein Wapstra, Diederik H R Kempen
Publikováno v:
Acta Orthopaedica, Vol 94 (2023)
Background and purpose: The Brace Questionnaire (BrQ) is a disease-specific health-related quality of life (HRQOL) instrument for measuring perceived health status of scoliosis patients undergoing brace treatment. The purpose of this study is to eval
Externí odkaz:
https://doaj.org/article/783573c3d39b4514966ee18e738e1bc5
Autor:
Jennifer M Luppino, Andrew Field, Son C Nguyen, Daniel S Park, Parisha P Shah, Richard J Abdill, Yemin Lan, Rebecca Yunker, Rajan Jain, Karen Adelman, Eric F Joyce
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010528 (2022)
The relationship between cohesin-mediated chromatin looping and gene expression remains unclear. NIPBL and WAPL are two opposing regulators of cohesin activity; depletion of either is associated with changes in both chromatin folding and transcriptio
Externí odkaz:
https://doaj.org/article/6f10829c89194c2f98ca805aea9865a4
Publikováno v:
eLife, Vol 10 (2021)
An RNA polymerase ribozyme that has been the subject of extensive directed evolution efforts has attained the ability to synthesize complex functional RNAs, including a full-length copy of its own evolutionary ancestor. During the course of evolution
Externí odkaz:
https://doaj.org/article/712107c19f934467961e7093da97caee
Autor:
Jelena Erceg, Jumana AlHaj Abed, Anton Goloborodko, Bryan R. Lajoie, Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Ruth B. McCole, Son C. Nguyen, Wren Saylor, Eric F. Joyce, T. Niroshini Senaratne, Mohammed A. Hannan, Guy Nir, Job Dekker, Leonid A. Mirny, C.-ting Wu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation a
Externí odkaz:
https://doaj.org/article/93745053c3604cd7b79badd5961d288d
Publikováno v:
eLife, Vol 8 (2019)
The formation and spatial arrangement of chromosome territories (CTs) in interphase has been posited to influence the outcome and frequency of genomic translocations. This is supported by correlations between the frequency of inter-chromosomal contac
Externí odkaz:
https://doaj.org/article/c2ddfdb787284ac58cedea321fd36ae2
Autor:
Andrey Poleshko, Cheryl L Smith, Son C Nguyen, Priya Sivaramakrishnan, Karen G Wong, John Isaac Murray, Melike Lakadamyali, Eric F Joyce, Rajan Jain, Jonathan A Epstein
Publikováno v:
eLife, Vol 8 (2019)
Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of
Externí odkaz:
https://doaj.org/article/c643add60c814c8f8717b69f653b18d6
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