Zobrazeno 1 - 10
of 62
pro vyhledávání: '"P. Elizabeth Rakoczy"'
Autor:
Lakshini Y. Herat, Vance B. Matthews, P. Elizabeth Rakoczy, Revathy Carnagarin, Markus Schlaich
Publikováno v:
International Journal of Endocrinology, Vol 2018 (2018)
The prevalence of diabetes is at pandemic levels in today’s society. Microvascular complications in organs including the eye are commonly observed in human diabetic subjects. Diabetic retinopathy (DR) is a prominent microvascular complication obser
Externí odkaz:
https://doaj.org/article/61d337a7d7174385b4550a8382ce78e4
Autor:
Vance B. Matthews, P. Elizabeth Rakoczy, Markus P. Schlaich, Lakshini Y. Herat, Revathy Carnagarin
Publikováno v:
International Journal of Endocrinology, Vol 2018 (2018)
International Journal of Endocrinology
International Journal of Endocrinology
The prevalence of diabetes is at pandemic levels in today’s society. Microvascular complications in organs including the eye are commonly observed in human diabetic subjects. Diabetic retinopathy (DR) is a prominent microvascular complication obser
Autor:
Andrew Advani, Darren J. Kelly, Suzanne L. Advani, Renae M. Gow, Philip A. Marsden, P. Elizabeth Rakoczy, Kathryn White, Sally M. Marshall, Alison J. Cox, Yuan Zhang, Brent M. Steer, Richard E. Gilbert, Kerri Thai
Publikováno v:
Proceedings of the National Academy of Sciences. 104:14448-14453
Inhibiting the actions of VEGF is a new therapeutic paradigm in cancer management with antiangiogenic therapy also under intensive investigation in a range of nonmalignant diseases characterized by pathological angiogenesis. However, the effects of V
Autor:
Nicholas Manolios, Robert J. Marano, P. Elizabeth Rakoczy, Enoch Chan, Philip Kearns, Istvan Toth, Norbert Wimmer, Michael Amon
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:4091-4097
In search of new oligodeoxynucleotide (ODN) delivery agents, we evaluated novel peptides derived from core peptide H-GLRILLLKV-OH (CP). CP is a fragment designed from the T-cell antigen receptor (TCR) alpha-chain transmembrane sequence. CP was able t
Publikováno v:
Experimental Eye Research. 82:741-752
Recent advances in genetic technologies have greatly accelerated our ability to find disease-related genes and to generate animal models. The availability of ocular tissues with known genetic diseases are greatly contributing to our understanding of
Publikováno v:
Cell and Tissue Research. 323:117-125
Tight junctions (TJ) between retinal pigmented epithelial (RPE) and retinal endothelial cells maintain the outer and inner blood-retinal barrier, and the breakdown of these barriers is associated with retinal diseases. Vascular endothelial growth fac
Publikováno v:
Stem Cells and Development. 14:15-28
Autologous stem cell transplantation combined with gene therapy can potentially be used to treat genetically inherited diseases. However, characterization of multipotential cells from a disease state remains extremely limited. We have characterized a
Autor:
M. Brankov, Istvan Toth, P. Elizabeth Rakoczy, Bradley G. Thomas, Norbert Wimmer, Philip Kearns, Robert J. Marano
Publikováno v:
Experimental Eye Research. 79:525-535
Ocular neovascularisation is the leading cause of blindness in developed countries and the most potent angiogenic factor associated with neovascularisation is vascular endothelial growth factor (VEGF). We have previously described a sense oligonucleo
Publikováno v:
Journal of Biological Chemistry. 279:37808-37814
The regulation of vascular endothelial growth factor (VEGF), a potent stimulator of angiogenesis, is controlled primarily through the interactions of control elements located within the 5′- and 3′-untranslated regions, many of which are yet to be
Publikováno v:
Clinical and Experimental Ophthalmology. 31:445-450
Background: The aim of the present study was to define the rhodopsin promoter elements of various mammalian species by evaluating the effect of these promoters on transgene specificity and expression in human cell lines. Additional characterization o