Zobrazeno 1 - 9
of 9
pro vyhledávání: '"P. E. Noker"'
Autor:
Linda Simpson-Herren, P. E. Noker
Publikováno v:
Cell Proliferation. 24:355-365
Failure of anti-cancer agents to reach all clonogenic cells at cytotoxic concentrations is recognized as an important form of resistance in solid tumours. Subcutaneously implanted mammary adenocarcinoma 16/C was used to evaluate the intratumour distr
Autor:
Linda Simpson-Herren, P. E. Noker
Publikováno v:
Cell Proliferation. 24:241-255
The response of solid mammary adenocarcinoma 16/C to treatment with Adriamycin is highly variable and ranges from growth under treatment to complete regression. Tumour and host factors were evaluated to determine the influence of each on the response
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 266(2)
Certain derivatives of 9-deazaguanine that contain arylmethyl, heteroarylmethyl or cycloalkylmethyl groups at the 9-position are potent inhibitors of purine nucleoside phosphorylase (PNP, E.C. 2.4.2.1). To determine whether these agents can produce m
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 217(1)
Formic acid does not accumulate in the rat after the administration of methanol as it does in methanol-poisoned humans and monkeys. In addition, rats do not manifest the metabolic acidosis and ocular toxicity characteristic of methanol intoxication i
Autor:
P E, Noker, D L, Hill
Publikováno v:
Cancer treatment reports. 71(12)
The distribution of the novel alkylating agent clomesone [2-chloroethyl (methylsulfonyl)-methane sulfonate] has been studied in mice after iv administration of 35 mg/kg. In plasma, [14C]clomesone was eliminated in an apparent single phase with a half
Autor:
P. E. Noker, Thomas R. Tephly
Publikováno v:
Alcohol and Aldehyde Metabolizing Systems-IV ISBN: 9781475714210
In the monkey and human, methanol toxicity is characterized by a metabolic acidosis and an ocular toxicity which occur coincident with an accumulation of formate in blood. In contrast, methanol insensitive species such as the rat do not accumulate fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5476ed9fbbbdc354b52d4b56cf817ee4
https://doi.org/10.1007/978-1-4757-1419-7_32
https://doi.org/10.1007/978-1-4757-1419-7_32
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 13(6)
The disposition of two 1-deaza-7,8-dihydropteridines, NSC 269416 and NSC 350386, was studied in mice dosed iv. After dosing with 25 mg/kg of NSC 269416, serum levels fell in two phases with half-lives of 3.1 and 32 min. Highest levels were in liver,
Publikováno v:
Cancer treatment reports. 65(5-6)
Blood and urine levels of thymidine and its catabolic product, thymine, have been determined for mice and rats given a single large dose of thymidine and for rats during and after infusion of large amounts of this drug. For mice given a bolus dose (4
Publikováno v:
Cancer treatment reports. 67(5)
The metabolic disposition of 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-phosphate (2-F-araAMP) has been studied in mice and dogs after iv administration. Following injection of 40 mg/m2 into mice, serum levels of 2-F-araAMP fell, with apparent half