Zobrazeno 1 - 10
of 15
pro vyhledávání: '"P. E. Finke"'
Autor:
P. E. Finke, Gary G. Chicchi, Nadia M.J. Rupniak, George J. Eiermann, Nancy N. Tsou, E. Ber, Angela Williams, W. Rycroft, Margaret A. Cascieri, Sander G. Mills, Richard Hargreaves, M. Maccoss, Joe Metzger, D. E. Macintyre, Myra B. Kurtz, Sharon Sadowski, J. J. Hale, F.D. Tattersall
Publikováno v:
Journal of Medicinal Chemistry. 41:4607-4614
Structural modifications requiring novel synthetic chemistry were made to the morpholine acetal human neurokinin-1 (hNK-1) receptor antagonist 4, and this resulted in the discovery of 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluor
Autor:
G. O. Chandler, P. E. Finke, J. B. Doherty, Karen A. Brause, H. Weston, W. B. Knight, S. K. Shah, Bonnie M. Ashe, Alan L. Maycock
Publikováno v:
ChemInform. 22
Autor:
Thomas J. Blacklock, Laura A. O'Grady, C. P. Jun. Dorn, G. O. Chandler, Raymond A. Firestone, Peter L. Barker, Kevan R. Thompson, Mary Ellen Dahlgren, Alan L. Maycock, Bonnie M. Ashe, Manuel A. Navia, S. K. Shah, W. B. Knight, P. Davies, Judith M. Pisano, Morris Zimmerman, W. K. Hagmann, J. B. Doherty, John W. Butcher, P. E. Finke, H. Weston, T. Halgren
Publikováno v:
ChemInform. 22
Autor:
H. Weston, P. E. Finke, D. J. Unterwood, J. B. Doherty, W. B. Knight, Kevan R. Thompson, Alan L. Maycock, Bonnie M. Ashe, Manuel A. Navia, S. K. Shah, Morris Zimmerman
Publikováno v:
ChemInform. 22
Autor:
S. K. Shah, H. Weston, W. K. Hagmann, Richard A. Mumford, Karen A. Brause, J. B. Doherty, D. S. Fletcher, W. B. Knight, C. P. Jun. Dorn, Dennis J. Underwood, Pam S. Dellea, J. J. Hale, Amy L. Kissinger, P. E. Finke, Karen M. Hand, Alan L. Maycock, Bonnie M. Ashe, G. O. Chandler
Publikováno v:
ChemInform. 24
Autor:
J. B. Doherty, P. Davies, P. E. Finke, H. Weston, Bonnie M. Ashe, G. O. Chandler, Pam S. Dellea, S. K. Shah, Karen M. Hand, Alan L. Maycock, Donald G. Osinga, Karen A. Brause, D. S. Fletcher, Dennis J. Underwood
Publikováno v:
ChemInform. 26
Autor:
S K, Shah, C P, Dorn, P E, Finke, J J, Hale, W K, Hagmann, K A, Brause, G O, Chandler, A L, Kissinger, B M, Ashe, H, Weston
Publikováno v:
Journal of Medicinal Chemistry. 35:3745-3754
A thorough analysis of the mechanism of inhibition of human leukocyte elastase (HLE) by a monocyclic beta-lactam and the mechanism of beta-lactam hydrolysis led to the preparation of potent and highly stable inhibitors of HLE. This work led to the id
Autor:
D J, Underwood, B G, Green, R, Chabin, S, Mills, J B, Doherty, P E, Finke, M, MacCoss, S K, Shah, C S, Burgey, T A, Dickinson
Publikováno v:
Biochemistry. 34(44)
A combination of NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS) was used to probe the identity of beta-lactam-derived complexes with serine proteases. The carbon and proton NMR chemical shifts of the human leucocyte elastase
Autor:
D S, Fletcher, D G, Osinga, K, Keenan, R J, Bonney, J B, Doherty, P E, Finke, S K, Shah, P, Davies
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(1)
The typical reverse passive Arthus reaction (RPA) was attained in rats by the instillation of a rabbit antiovalbumin serum into the lungs and intravenous injection of ovalbumin. Instillation of antiserum alone caused accumulation of polymorphonuclear
Autor:
P E, Finke, S K, Shah, D S, Fletcher, B M, Ashe, K A, Brause, G O, Chandler, P S, Dellea, K M, Hand, A L, Maycock, D G, Osinga
Publikováno v:
Journal of medicinal chemistry. 38(13)
The stereospecific synthesis of several 4-[(4-carboxyphenyl)oxy]- 3,3-dialkyl-1-[[(1-phenylalkyl)-amino]carbonyl]azetidin-2-on es 3 is described in which the C-3 alkyl groups were varied from methyl to butyl as well as allyl, benzyl and methoxymethyl