Zobrazeno 1 - 10
of 20
pro vyhledávání: '"P. E. Fagerness"'
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::025eb6e1eca559b93d2274ed32ca1660
https://doi.org/10.1002/chin.199731206
https://doi.org/10.1002/chin.199731206
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 33(10)
1. The antitumour agent bropirimine undergoes significant Phase II conjugation in vivo. Incubation of [14C]bropirimine with human liver microsomes resulted in the formation of a single product peak (M1) using high-performance liquid chromatography wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9671bb851026661881626d14738b70
https://pubmed.ncbi.nlm.nih.gov/14555337
https://pubmed.ncbi.nlm.nih.gov/14555337
Autor:
J G, Slatter, D J, Stalker, K L, Feenstra, I R, Welshman, J B, Bruss, J P, Sams, M G, Johnson, P E, Sanders, M J, Hauer, P E, Fagerness, R P, Stryd, G W, Peng, E M, Shobe
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(8)
Linezolid (Zyvox), the first of a new class of antibiotics, the oxazolidinones, is approved for treatment of Gram-positive bacterial infections, including resistant strains. The disposition of linezolid in human volunteers was determined, after a 500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::877677956dba5cbdfabc07e05ce75c48
https://pubmed.ncbi.nlm.nih.gov/11454733
https://pubmed.ncbi.nlm.nih.gov/11454733
Autor:
M, Chang, V K, Sood, D A, Kloosterman, M J, Hauer, P E, Fagerness, P E, Sanders, J J, Vrbanac
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(7)
Delavirdine mesylate (U-90152T) is a highly specific nonnucleoside HIV-1 reverse transcriptase inhibitor currently under development for the treatment of AIDS. The metabolism of delavirdine was investigated in male and female cynomolgus monkeys after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::612dded9eda8a281765e98f26d8607dd
https://pubmed.ncbi.nlm.nih.gov/9224776
https://pubmed.ncbi.nlm.nih.gov/9224776
Autor:
P, Gao, P E, Fagerness
Publikováno v:
Pharmaceutical research. 12(7)
This work describes diffusivity measurements of drug (adinazolam mesylate) and water in a variety of solutions including polymer gels.Pulsed-field-gradient spin-echo (PFGSE) NMR methods were employed to measure the diffusivity.In binary component sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30097a600a1e6d781745d21dc7b36eeb
https://pubmed.ncbi.nlm.nih.gov/7494815
https://pubmed.ncbi.nlm.nih.gov/7494815
Publikováno v:
Pharmaceutical research. 10(1)
Understanding how moisture interacts with a drug or formulation is a critical component of product development. This study demonstrates how water affects the 3'-gem-diol==3'-keto equilibrium in trospectomycin sulfate bulk drug and freeze-dried formul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10e31803dfbe9f5fc4821552ca6ed1ea
https://pubmed.ncbi.nlm.nih.gov/8430063
https://pubmed.ncbi.nlm.nih.gov/8430063
Publikováno v:
Proteins: Structure, Function, and Genetics. 4:48-55
The solution structure of a 38-amino-acid-residue, biologically active fragment of bovine growth hormone (bGH96-133) was investigated with a combined nuclear magnetic resonance (NMR) and computer modeling approach. With the distance geometry program
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808267bfa53efd6ef9b8ffb0e31673e0
https://doi.org/10.1002/prot.340040107
https://doi.org/10.1002/prot.340040107
Publikováno v:
Biochemistry. 25:905-912
The procedures for the generation of enzyme-substrate complexes from labeled porphobilinogens [(2,11-13C]PBG and [2,6,11-3H]PBG) with deaminase and the methods employed for their purification are described. Use of 13C NMR failed to detect the substra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432085578e0f7b4e71214b143e8a6d97
https://doi.org/10.1021/bi00352a025
https://doi.org/10.1021/bi00352a025
Autor:
W J VandenHeuvel, K L Kennicott, P H Gale, P E Fagerness, R W Walker, R W Egan, F A Kuehl, E M Baptista
Publikováno v:
Journal of Biological Chemistry. 256:7352-7361
oxidations of organic sulfides, amines, and even enzymes catalyzed by purified and microsomal forms of prostaglandin cyclooxygenase-hydroperoxidase have been studied using O2 incorporation into arachidonic acid to monitor oxygenase and [14C]15-hydrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f39a29b9ccfcd5fad986df92abe27e8b
https://doi.org/10.1016/s0021-9258(19)68970-2
https://doi.org/10.1016/s0021-9258(19)68970-2
Publikováno v:
The Journal of Chemical Physics. 60:5066-5069
The 13C spin‐lattice relaxation times of both the ring and methyl carbons in the liquid crystal, p‐azoxydianisole, are reported as a function of temperature on both sides of the clearing point. In marked contrast to earlier results on proton rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::303f13e25163b1586ff80248bc142636
https://doi.org/10.1063/1.1681023
https://doi.org/10.1063/1.1681023