Zobrazeno 1 - 10
of 32
pro vyhledávání: '"P. E. Beales"'
Autor:
P. E. Beales, Paolo Pozzilli
Publikováno v:
Diabetes/Metabolism Research and Reviews. 18:114-117
Background Thiazolidinediones (TZDs) are a recently introduced generation of drugs acting as receptor agonists to reduce insulin resistance and used currently in combination with other hypoglycaemic agents for the treatment of type 2 diabetes. In add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ef9ec85a26a710ac89b1a15baba89d
https://doi.org/10.1002/dmrr.262
https://doi.org/10.1002/dmrr.262
Publikováno v:
Autoimmunity. 35:329-333
The non-obese diabetic (NOD) mouse is a model of spontaneous type-1 diabetes used in the field of diabetes research. This study looked at the adrenal glands of NOD and control mice both indirectly in vivo for hormone secretion, and directly in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595d0181f99167eb0113abd24f62e610
https://doi.org/10.1080/0891693021000003189
https://doi.org/10.1080/0891693021000003189
Publikováno v:
Autoimmunity. 32:109-113
In vitro cell mediated reactivity to Glutamic Acid Decarboxylase (GAD) has been reported in man and in the non-obese diabetic (NOD) mouse. The demonstration of such reactivity in vivo using GAD in a simple intradermal skin test would be useful for ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6403af14b769a40c555cd7d7d397e2
https://doi.org/10.3109/08916930008994080
https://doi.org/10.3109/08916930008994080
Publikováno v:
Diabetes/Metabolism Research and Reviews. 15:21-28
Background The non-obese diabetic (NOD) mouse is a widely used model of Type 1 diabetes mellitus (Type 1 DM), which displays many of the characteristics of the disease found in humans. Nicotinamide (NA) is currently being tested in large-scale, multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d90d75b08efab4f46d59384369f3a258
https://doi.org/10.1002/(sici)1520-7560(199901/02)15:1<21::aid-dmrr16>3.0.co
https://doi.org/10.1002/(sici)1520-7560(199901/02)15:1<21::aid-dmrr16>3.0.co
Autor:
Paolo Pozzilli, P. E. Beales, Roberto Liddi, Kenneth Batchelor, Alberto Signore, E. Procaccini, A. Giorgini
Publikováno v:
European Journal of Pharmacology. 357:221-225
Troglitazone has recently been introduced in the treatment of Type 2 diabetes. In addition to its anti-diabetic effects it acts as a perixosome proliferator activated receptor-gamma (PPAR-gamma) agonist and has anti-inflammatory properties by inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d408975db0333fc4c4b518a8cc5e66
https://doi.org/10.1016/s0014-2999(98)00574-3
https://doi.org/10.1016/s0014-2999(98)00574-3
Autor:
P. E. Beales, Alberto Signore, E. Procaccini, Giovina Ruberti, Roberto Testi, A. Annovazzi, J. Spencer
Publikováno v:
Diabetologia. 40:1476-1479
The non-obese diabetic (NOD) mouse is widely used to study the pathogenesis of insulin-dependent diabetes mellitus. However, the mechanisms responsible for beta-cell destruction, in this model, are still poorly defined. The CD95/CD95L system among ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29402934d0b7bf5ac87041a3d3dfc4e
https://doi.org/10.1007/s001250050852
https://doi.org/10.1007/s001250050852
Autor:
A. Giorgini, Paolo Pozzilli, P. E. Beales, Maria Cristina Albertini, A. J. K. Williams, Mohammed I. Hawa
Publikováno v:
Acta Diabetologica. 32:53-56
Glutamic acid decarboxylase (GAD) is the enzyme responsible for the synthesis of gamma-aminobutyric acid (GABA). GAD has been identified as a 64-kDa antigen expressed in pancreatic beta-cells, to which autoantibodies are generated prior to the onset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa56f6cd178847b9276ccfeb5bd7c3a
https://doi.org/10.1007/bf00581047
https://doi.org/10.1007/bf00581047
Autor:
Pietro Cugini, Alberto Signore, P. E. Beales, A. J. K. Williams, Elisabetta Ferretti, A. M. Toscano, E. Procaccini, Paolo Pozzilli
Publikováno v:
Histochemistry. 101:263-269
Non-obese diabetic (NOD) mice spontaneously develop an autoimmune diabetes with higher incidence in females than in males. In order to elucidate possible factors involved in the different incidence of diabetes between male and female mice, we studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de0cfc37cdf35ebd8afcab6a7267580
https://doi.org/10.1007/bf00315913
https://doi.org/10.1007/bf00315913
Publikováno v:
Diabetes Research and Clinical Practice. 21:5-9
It has been suggested that heparin and its analogues may have a suppressive effect on the immune response by interfering with T-lymphocyte heparinase activity, thus altering the ability of T-lymphocytes to penetrate the extracellular matrix and migra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06da6f3edcf8abe0ae707224fb9848db
https://doi.org/10.1016/0168-8227(93)90090-r
https://doi.org/10.1016/0168-8227(93)90090-r
Autor:
E. Procaccini, Alberto Signore, E. A. M. Gale, J. Krug, Paolo Pozzilli, P. E. Beales, A. J. K. Williams, S. Xu
Publikováno v:
Diabetologia. 36:487-492
The functional state of beta cells may influence the rate of their destruction in Type 1 (insulin-dependent) diabetes mellitus. We examined the effect of diazoxide, which inhibits insulin secretion, or tolbutamide, which stimulates insulin secretion,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c503e53c02b22b70bc4e3959da22fe0
https://doi.org/10.1007/bf02743262
https://doi.org/10.1007/bf02743262