Zobrazeno 1 - 8
of 8
pro vyhledávání: '"P. E. Aldrich"'
Autor:
Patrick Y.S. Lam, Y. Ru, Prabhakar K. Jadhav, M. M. Rayner, Beverly C. Cordova, P. E. Aldrich, R. P. Meade
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:1635-1640
DMP 323, a C-2-symmetrical cyclic urea, is representative of a new class of inhibitors of human immunodeficiency virus protease. In this study, we correlate the potent antiviral activity of DMP 323 in acute infections with antiprotease activity asses
Autor:
Dean L. Winslow, Sena Garber, Caroline Reid, Y. S. E. Cheng, Hodge Carl Nicholas, C. E. Patterson, P. E. Aldrich, Prabhakar K. Jadhav, M. J. Otto
Publikováno v:
Proceedings of the National Academy of Sciences. 90:7543-7547
Protease inhibitors are another class of compounds for treatment of human immunodeficiency virus (HIV)-caused disease. The emergence of resistance to the current anti-HIV drugs makes the determination of potential resistance to protease inhibitors im
Autor:
Y. Ru, G. Emmett, Qi Han, Edward R. Holler, T. R. Sharpe, M. M. Rayner, Hodge Carl Nicholas, Renhua Li, Dean L. Winslow, Robert J. McHugh, P. E. Aldrich, George Vincent Delucca, P. N. Confalone, Jay A. Markwalder, Prabhakar K. Jadhav, L. Li, Steven P. Seitz, C.-H. Chang, Susan Erickson-Viitanen, Charles J. Eyermann, Patrick Y.S. Lam, D. M. Kornhauser, L. Shum, Lee T. Bacheler, David A. Jackson, W. F. Daneker, Ronald M. Klabe
Publikováno v:
Journal of medicinal chemistry. 39(18)
High-resolution X-ray structures of the complexes of HIV-1 protease (HIV-1PR) with peptidomimetic inhibitors reveal the presence of a structural water molecule which is hydrogen bonded to both the mobile flaps of the enzyme and the two carbonyls flan
Autor:
P. E. Aldrich, M. Paulshock, W. W. Prichard, W. E. Meier, J. C. Watts, E. C. Hermann, J. A. Snyder
Publikováno v:
Journal of Medicinal Chemistry. 14:535-543
Autor:
P. E. Aldrich, William A. Sheppard
Publikováno v:
The Journal of Organic Chemistry. 29:11-15
Publikováno v:
The Journal of Organic Chemistry. 28:184-188
Autor:
Hodge Carl Nicholas, M. J. Otto, Sena Garber, Dean L. Winslow, Grubb M, L. Shum, Korant B, Patrick Y.S. Lam, J. L. Meek, P. E. Aldrich, Charles J. Eyermann, Lee T. Bacheler, M. M. Rayner, T. R. Sharpe, Prabhakar K. Jadhav, C.-H. Chang, Susan Erickson-Viitanen, Carol Reid, David A. Jackson, Maurin Mb
Publikováno v:
Chemistry & Biology. (4):301-314
Background: Effective HIV protease inhibitors must combine potency towards wild-type and mutant variants of HIV with oral bioavailability such that drug levels in relevant tissues continuously exceed that required for inhibition of virus replication.
Autor:
J. A. Snyder, W. E. Meier, W. W. Prichard, P. E. Aldrich, M. Paulshock, E. C. Hermann, J. C. Watts
Publikováno v:
Chemischer Informationsdienst. Organische Chemie. 2