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Akademický článek

Renal extramedullary hematopoiesis as an epiphenomenon of bone marrow dysfunction in a patient with primary myelofibrosis: A rare case report

Autor: Corrado Ini’, MD, Pietro Valerio Foti, PhD, Andrea Duminuco, MD, Renato Farina, MD, Mariangela Clemenza, MD, Francesco Tiralongo, MD, Emanuele David, MD, Stefano Palmucci, PhD, Giuseppe Alberto Palumbo, PhD, Antonio Basile, PhD

Publikováno v: Radiology Case Reports, Vol 19, Iss 6, Pp 2286-2291 (2024)

Extramedullary hematopoiesis represents a clinical compensatory condition characterized by the growth of hematopoietic tissue outside the bone marrow. It can mainly occur in patient with myeloproliferative disorders where alteration or neoplastic inv

Externí odkaz: https://doaj.org/article/f55aa986909846e9b48a661dbd6161af

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Akademický článek

Polycythemia Vera: Barriers to and Strategies for Optimal Management

Autor: Duminuco A, Harrington P, Harrison C, Curto-Garcia N

Publikováno v: Blood and Lymphatic Cancer: Targets and Therapy, Vol Volume 13, Pp 77-90 (2023)

Andrea Duminuco,1,2 Patrick Harrington,1 Claire Harrison,1 Natalia Curto-Garcia1 1Department of Haematology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK; 2Haematology with BMT Unit, A.O.U. Policlinico “G.Rodolico-San Marco”, Catania

Externí odkaz: https://doaj.org/article/2fc6f939593746a88803f217fc6ae9f0

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Akademický článek

Transient Leukemoid Reaction from T-Cell Large Granular Lymphocytes Post Autologous Stem Cell Transplant in a Patient Affected by Hodgkin Lymphoma

Autor: Andrea Duminuco, Marina Parisi, Giulio Antonio Milone, Alessandra Cupri, Salvatore Leotta, Giuseppe A. Palumbo, Nunziatina Laura Parrinello, Grazia Scuderi, Anna Triolo, Giuseppe Milone

Publikováno v: Hematology Reports, Vol 15, Iss 4, Pp 555-561 (2023)

Monoclonal T-cell lymphocytosis has been reported in patients with concomitant autoimmune diseases, viral infections, or immunodeficiencies. Referred to as T-cell large granular lymphocytic leukemia (T-LGLL), most cases cannot identify the triggering

Externí odkaz: https://doaj.org/article/b363952c5cb6454887231743dd406b7d

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Akademický článek

MacroH2A1.1 as a crossroad between epigenetics, inflammation and metabolism of mesenchymal stromal cells in myelodysplastic syndromes

Publikováno v: Cell Death and Disease, Vol 14, Iss 10, Pp 1-11 (2023)

Abstract Ineffective hematopoiesis is a hallmark of myelodysplastic syndromes (MDS). Hematopoietic alterations in MDS patients strictly correlate with microenvironment dysfunctions, eventually affecting also the mesenchymal stromal cell (MSC) compart

Externí odkaz: https://doaj.org/article/8a2eeb6046584786b526024112b70f40

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Akademický článek

Additional Genetic Alterations and Clonal Evolution of MPNs with Double Mutations on the MPL Gene: Two Case Reports

Autor: Maria Stella Pennisi, Sandra Di Gregorio, Elena Tirrò, Chiara Romano, Andrea Duminuco, Bruno Garibaldi, Gaetano Giuffrida, Livia Manzella, Paolo Vigneri, Giuseppe A. Palumbo

Publikováno v: Hematology Reports, Vol 15, Iss 2, Pp 317-324 (2023)

Essential thrombocythemia (ET) and primary myelofibrosis (PMF) are two of the main BCR-ABL1-negative chronic myeloproliferative neoplasms (MPNs) characterized by abnormal megakaryocytic proliferation. Janus kinase 2 (JAK2) mutations are detected in 5

Externí odkaz: https://doaj.org/article/0f2895a965554aea8fd58e369039bcf1

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Akademický článek

Assessment of the efficacy and tolerability of ruxolitinib for the treatment of myelofibrosis patients in a real‐life setting: An Italian MYNERVA Project

Publikováno v: Cancer Medicine, Vol 12, Iss 7, Pp 8166-8171 (2023)

Abstract Background Incorporating real‐world data in the drug development process allows the improvement of health outcomes by providing better representation of actual patterns of drug safety and efficacy. Aims and Methods Here, we present the res

Externí odkaz: https://doaj.org/article/1f0711b6747549bf9014fa11c81493be

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Akademický článek

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Akademický článek

AIPSS‐MF machine learning prognostic score validation in a cohort of myelofibrosis patients treated with ruxolitinib

Autor: Andrea Duminuco, Adrian Mosquera‐Orgueira, Antonella Nardo, Francesco Di Raimondo, Giuseppe Alberto Palumbo

Publikováno v: Cancer Reports, Vol 6, Iss 10, Pp n/a-n/a (2023)

Abstract Background In myelofibrosis (MF), new model scores are continuously proposed to improve the ability to better identify patients with the worst outcomes. In this context, the Artificial Intelligence Prognostic Scoring System for Myelofibrosis

Externí odkaz: https://doaj.org/article/54ba6c76e1b441e48b949a27405de65e

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Akademický článek

Potential clinical impact of T-cell lymphocyte kinetics monitoring in patients with B cell precursors acute lymphoblastic leukemia treated with blinatumomab: a single-center experience

Autor: Andrea Duminuco, Uros Markovic, Nunziatina Laura Parrinello, Luca Lo Nigro, Elisa Mauro, Calogero Vetro, Marina Parisi, Cinzia Maugeri, Paolo Fabio Fiumara, Giuseppe Milone, Alessandra Romano, Francesco Di Raimondo, Salvatore Leotta

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Blinatumomab is a bispecific anti-CD3 and anti-CD19 antibody that acts as a T-cell engager: by binding CD19+ lymphoblasts, blinatumomab recruits cytotoxic CD3+ T-lymphocytes to target the cancer cells. Here we describe seven different patients affect

Externí odkaz: https://doaj.org/article/6d1ea67282854a9192f0384a596efbcd

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