Zobrazeno 1 - 10
of 741
pro vyhledávání: '"P. Duddy"'
Autor:
Rinako Nakagawa, Miriam Llorian, Sunita Varsani-Brown, Probir Chakravarty, Jeannie M. Camarillo, David Barry, Roger George, Neil P. Blackledge, Graham Duddy, Neil L. Kelleher, Robert J. Klose, Martin Turner, Dinis P. Calado
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract To increase antibody affinity against pathogens, positively selected GC-B cells initiate cell division in the light zone (LZ) of germinal centers (GCs). Among these, higher-affinity clones migrate to the dark zone (DZ) and vigorously prolife
Externí odkaz:
https://doaj.org/article/84234ec349554abfa6f1048d4cadc502
Publikováno v:
GHMJ (Global Health Management Journal), Vol 7, Iss 4 (2024)
Background: Adolescents are among the groups vulnerable to nutritional problems. These issues can arise due to restrictive diets, self-assessment (body image), lifestyle choices, energy intake, physical activity, and knowledge of balanced nutrition.
Externí odkaz:
https://doaj.org/article/459d813a112b4542b138c0314085c451
Autor:
Morag A. Lewis, Maria Lachgar-Ruiz, Francesca Di Domenico, Graham Duddy, Jing Chen, Sergio Fernandez, Matias Morin, Gareth Williams, Miguel Angel Moreno Pelayo, Karen P. Steel
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Progressive hearing loss is a common problem in the human population with no effective therapeutics currently available. However, it has a strong genetic contribution, and investigating the genes and regulatory interactions underl
Externí odkaz:
https://doaj.org/article/18ebda7be878464080ab6f75b1462e0e
Autor:
Hillary Elrick, Kevin A. Peterson, Brandon J. Willis, Denise G. Lanza, Elif F. Acar, Edward J. Ryder, Lydia Teboul, Petr Kasparek, Marie-Christine Birling, David J. Adams, Allan Bradley, Robert E. Braun, Steve D. Brown, Adam Caulder, Gemma F. Codner, Francesco J. DeMayo, Mary E. Dickinson, Brendan Doe, Graham Duddy, Marina Gertsenstein, Leslie O. Goodwin, Yann Hérault, Lauri G. Lintott, K. C. Kent Lloyd, Isabel Lorenzo, Matthew Mackenzie, Ann-Marie Mallon, Colin McKerlie, Helen Parkinson, Ramiro Ramirez-Solis, John R. Seavitt, Radislav Sedlacek, William C. Skarnes, Damien Smedley, Sara Wells, Jacqueline K. White, Joshua A. Wood, International Mouse Phenotyping Consortium, Stephen A. Murray, Jason D. Heaney, Lauryl M. J. Nutter
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease Cas9 for i
Externí odkaz:
https://doaj.org/article/0788cc9d0e59472c90243baecc221f96
Publikováno v:
GHMJ (Global Health Management Journal), Vol 7, Iss 4 (2024)
Background: Previous studies have indicated that exposure to social media can impact adolescents' nutritional intake. Given that 87.5% of Indonesian adolescents use the internet to access social media. Aims: This study aims to analyze how exposure
Externí odkaz:
https://doaj.org/article/6fa1ca6195fe4741ba642af6bc7c86ab
Autor:
Tracey McConnell, Carolyn Blair, Geoff Wong, Claire Duddy, Clare Howie, Loreena Hill, Joanne Reid
Publikováno v:
Health and Social Care Delivery Research, Vol 12, Iss 34 (2024)
Background Cardiovascular disease is the most common cause of death worldwide, highlighting the need for studies to determine options for palliative care within the management of patients with heart failure. Although there are promising examples of i
Externí odkaz:
https://doaj.org/article/e1cd9a4f13a24833a40ea6aff064b669
Autor:
Alan J Thompson, Charles Wade, Nevin John, Jeremy Chataway, Gavin Giovannoni, Rachael Hunter, Sreedharan Harikrishnan, Floriana De Angelis, Olga Ciccarelli, Eli Silber, John Greenwood, Thomas Williams, Martin Duddy, Basil Sharrack, Annie Hawton, Siddharthan Chandran, Sue Pavitt, Paul Gallagher, Ian Galea, Jennifer M Nicholas, Tarunya Arun, Miriam Mattoscio, Richard Nicholas, Neil Robertson, Carolyn Young, Jeremy Hobart, David Rog, Owen Pearson, Anisha Doshi, Timothy Harrower, Leonora Fisniku, Ruth Geraldes, Nikos Evangelou, Judy Beveridge, Matthew Craner, Don Mahad, Stefano Pluchino, Suresh Chhetri, Susan Tebbs, Marie Braisher, Seema Kalra, Charles Hillier, Chris Frost, Gavin McDonnell, Stuart J Nixon, Helen L Ford, Jeban Ganesalingam, Claire Rice, Alberto Calvi, Cord Spilker, Abdullah Shehu, Martin Lee, James Blackstone, Alessia Bianchi, Agne Straukiene, Gil Barton, Fayyaz Ahmed, Dawn Lyle, Ekaterina Bordea, Sean Apap Mangion, Rachel Merry, Elisabeth Jarman
Publikováno v:
BMJ Open, Vol 14, Iss 9 (2024)
Introduction There remains a high unmet need for disease-modifying therapies that can impact disability progression in secondary progressive multiple sclerosis (SPMS). Following positive results of the phase 2 MS-STAT study, the MS-STAT2 phase 3 tria
Externí odkaz:
https://doaj.org/article/69619bde66e34a6986cbeaf0b8bdc802
Autor:
Nevin John, Jeremy Chataway, Jacqueline Palace, Gavin Giovannoni, David Paling, Frederik Barkhof, Floriana De Angelis, Lorraine Smith, Thomas Williams, Martin Duddy, James Overell, Basil Sharrack, Sebastien Ourselin, Allan Walker, Siddharthan Chandran, Richard Nicholas, Shuna Colville, Peter Connick, Carolyn Young, Jeremy Hobart, Anisha Doshi, Sharmilee Gnanapavan, Helen Ford, Baljean Dhillon, Thanh Phan, Arman Eshaghi, Julia Aram, Nigel Stallard, James Cameron, Brendan McLean, Matthew Craner, Domenico Plantone, Jonathan Stutters, Ferran Prados Carrasco, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Clive Hawkins, Roger Bastow, Daisy Mollison, Waqar Rashid, Joe Guadagno, Nikolaos Evangelou, Seema Kalra, Alberto Calvi, Yingtong Li, Tiggy Beyene, Vanessa Bassan, Alvin Zapata, Dawn Lyle, Heinke Arndt
Publikováno v:
BMJ Neurology Open, Vol 6, Iss 2 (2024)
Background The brain reserve hypothesis posits that larger maximal lifetime brain growth (MLBG) may confer protection against physical disability in multiple sclerosis (MS). Larger MLBG as a proxy for brain reserve, has been associated with reduced p
Externí odkaz:
https://doaj.org/article/03779c5cc9264a67966bb74f4a5ef24d
Autor:
Michelle Major, David A. Ellis, Andrea Williamson, Sharon Simpson, Claire Duddy, Geoff Wong, Calum Lindsay, Kate O'Donnell, Mhairi Mackenzie, David Baruffati
Publikováno v:
NIHR Open Research, Vol 3 (2024)
Background This protocol describes a realist review exploring the problem of “missingness” in healthcare, defined as the repeated tendency not to take up offers of care that has a negative impact on the person and their life chances. More specifi
Externí odkaz:
https://doaj.org/article/da6cb5ceaae249399b42a8f77b9550a4
Publikováno v:
Frontiers in Reproductive Health, Vol 6 (2024)
This Perspectives article reflects on findings from our systematic review about adolescent dysmenorrhoea Q, drawing on sociology of diagnosis theory. We consider tensions and uncertainties between presentation with symptoms of dysmenorrhoea and proce
Externí odkaz:
https://doaj.org/article/508326389d7e4d2c9c12b5a4dc7c9699