Zobrazeno 1 - 10
of 42
pro vyhledávání: '"P. Douglas Renfrew"'
Autor:
Jacob Kronenberg, Stanley Chu, Andrew Olsen, Dustin Britton, Leif Halvorsen, Shengbo Guo, Ashwitha Lakshmi, Jason Chen, Maria Jinu Kulapurathazhe, Cetara A. Baker, Benjamin C. Wadsworth, Cynthia J. Van Acker, John G. Lehman III, Tamara C. Otto, P. Douglas Renfrew, Richard Bonneau, Jin Kim Montclare
Publikováno v:
ChemistryOpen, Vol 13, Iss 7, Pp n/a-n/a (2024)
Abstract Organophosphates (OPs) are a class of neurotoxic acetylcholinesterase inhibitors including widely used pesticides as well as nerve agents such as VX and VR. Current treatment of these toxins relies on reactivating acetylcholinesterase, which
Externí odkaz:
https://doaj.org/article/8f4d8af828f44902b6adbee11cd5a1ea
Autor:
Julia Koehler Leman, Pawel Szczerbiak, P. Douglas Renfrew, Vladimir Gligorijevic, Daniel Berenberg, Tommi Vatanen, Bryn C. Taylor, Chris Chandler, Stefan Janssen, Andras Pataki, Nick Carriero, Ian Fisk, Ramnik J. Xavier, Rob Knight, Richard Bonneau, Tomasz Kosciolek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract For the past half-century, structural biologists relied on the notion that similar protein sequences give rise to similar structures and functions. While this assumption has driven research to explore certain parts of the protein universe, i
Externí odkaz:
https://doaj.org/article/3328dcc008b148b793b1b27ff83e69f8
Autor:
Vladimir Gligorijević, P. Douglas Renfrew, Tomasz Kosciolek, Julia Koehler Leman, Daniel Berenberg, Tommi Vatanen, Chris Chandler, Bryn C. Taylor, Ian M. Fisk, Hera Vlamakis, Ramnik J. Xavier, Rob Knight, Kyunghyun Cho, Richard Bonneau
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The rapid increase in the number of proteins in sequence databases and the diversity of their functions challenge computational approaches for automated function prediction. Here, the authors introduce DeepFRI, a Graph Convolutional Network for predi
Externí odkaz:
https://doaj.org/article/38a935b25ce6438ca4cd1a800c3d5727
Autor:
Dustin Britton, Michael Meleties, Chengliang Liu, Sihan Jia, Farbod Mahmoudinobar, P. Douglas Renfrew, Richard Bonneau, Jin Kim Montclare
Publikováno v:
Molecular Systems Design & Engineering. 8:217-226
Higher-order supramolecular assembly of a coiled-coil protein can be modulated by iterative tuning of its electrostatic potential.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca2e76556957b7e7d3e459aa267b405c
https://doi.org/10.1039/d2me00153e
https://doi.org/10.1039/d2me00153e
Autor:
Lindsay K. Hill, Dustin Britton, Teeba Jihad, Kamia Punia, Xuan Xie, Erika Delgado-Fukushima, Che Fu Liu, Orin Mishkit, Chengliang Liu, Chunhua Hu, Michael Meleties, P. Douglas Renfrew, Richard Bonneau, Youssef Z. Wadghiri, Jin Kim Montclare
Publikováno v:
Molecular Systems Design & Engineering. 7:915-932
This protein–iron oxide hybrid biomaterial aims to integrate the drug encapsulating potential of a coiled-coil protein with peptide-driven iron oxide biomineralization to serve as drug-carrying, MRI-detectable mesofiber.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f85ebe27bc3b119cc7e2fc33d350ba1
https://doi.org/10.1039/d2me00002d
https://doi.org/10.1039/d2me00002d
Autor:
Kamia Punia, Dustin Britton, Katharina Hüll, Liming Yin, Yifei Wang, P. Douglas Renfrew, M. Lane Gilchrist, Richard Bonneau, Dirk Trauner, Jin K. Montclare
Publikováno v:
Soft matter.
Fluorescent protein biomaterials have important applications such as bioimaging in pharmacological studies. Self-assembly of proteins, especially into fibrils, is known to produce fluorescence in the blue band. Capable of self-assembly into nanofiber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb798f56e107897bf3018cb91ab2fb2b
https://pubmed.ncbi.nlm.nih.gov/36538008
https://pubmed.ncbi.nlm.nih.gov/36538008
Energy minimization is necessary for virtually all modeling and design tasks and involves traversing extremely rugged energy landscapes. Although the gradient descent based minimization routines in Rosetta have fast runtimes, due to these rugged land
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e19727f4ae720f4b7c84985feeddeb4b
https://doi.org/10.1101/2022.12.19.521113
https://doi.org/10.1101/2022.12.19.521113
Autor:
Dustin Britton, Kamia Punia, Farbod Mahmoudinobar, Takuya Tada, Xunqing Jiang, P. Douglas Renfrew, Richard Bonneau, Nathaniel R. Landau, Xiang-Peng Kong, Jin Kim Montclare
Publikováno v:
Biochemical engineering journal. 187
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic since December 2019, and with it, a push for innovations in rapid testing and neutralizing antibody treatments in an effort to solve the spread and fatality of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f42b30d765c92b0288a5621a2a8019
https://pubmed.ncbi.nlm.nih.gov/36034180
https://pubmed.ncbi.nlm.nih.gov/36034180
Autor:
Julia Koehler Leman, Pawel Szczerbiak, P. Douglas Renfrew, Vladimir Gligorijevic, Daniel Berenberg, Tommi Vatanen, Bryn C. Taylor, Chris Chandler, Stefan Janssen, Andras Pataki, Nick Carriero, Ian Fisk, Ramnik J. Xavier, Rob Knight, Richard Bonneau, Tomasz Kosciolek
Publikováno v:
Nature communications, vol 14, iss 1
/ SummaryFor the past half-century, structural biologists relied on the notion that similar protein sequences give rise to similar structures and functions. While this assumption has driven research to explore certain parts of the protein universe, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c33b3507c8c28920ea5ea373a764f4b
https://doi.org/10.1101/2022.03.18.484903
https://doi.org/10.1101/2022.03.18.484903
Autor:
Paul Douglas Renfrew, Michele Molinari
Publikováno v:
Canadian Journal of Gastroenterology, Vol 26, Iss 10, Pp 705-710 (2012)
OBJECTIVE: To characterize the patient population served by Atlantic Canada’s Multi-Organ Transplant Program liver transplant service over the first five years of activity in its current iteration.
Externí odkaz:
https://doaj.org/article/d5934f4afc6d4f8f96bdc950b9b37468