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Akademický článek
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Autor:
M. Barth, V. Peyrou, Frank Porreca, Jean-Louis Junien, Wenhong Guo, P. Dodey, D. Pruneau, Todd W. Vanderah, Jean-Michel Luccarini
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 318:195-205
The antinociceptive pharmacology of N -[[4-(4,5-dihydro-1 H -imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl) sulfonyl]methylamino]ethoxy]- N -methylacetamide fumarate (LF22-0542), a novel nonpeptidic B 1 antagonist, was characteriz
Autor:
Boubia, Benaïssa, Poupardin, Olivia, Barth, Martine, Binet, Jean, Peralba, Philippe, Mounier, Laurent, Jacquier, Elise, Gauthier, Emilie, Lepais, Valérie, Chatar, Maryline, Ferry, Stéphanie, Thourigny, Anne, Guillier, Fabrice, Llacer, Jonathan, Amaudrut, Jérome, Dodey, Pierre, Lacombe, Olivier, Masson, Philippe, Montalbetti, Christian, Wettstein, Guillaume
Publikováno v:
Journal of Medicinal Chemistry; 3/22/2018, Vol. 61 Issue 6, p2246-2265, 20p
Publikováno v:
Organic Preparations and Procedures International. 27:500-503
Publikováno v:
ChemInform. 23
We report, in this letter, the enantioselective synthesis of four isomeric functionalized epoxides ( 3a , 3b , 3c and 3d ) which are useful building blocks for the synthesis of 2-nor-leukotriene analogues. All four epoxides are formally derived from
Publikováno v:
ChemInform. 26
Publikováno v:
ChemInform. 26
Publikováno v:
Tetrahedron: Asymmetry. 3:355-358
We report, in this letter, the enantioselective synthesis of four isomeric functionalized epoxides ( 3a , 3b , 3c and 3d ) which are useful building blocks for the synthesis of 2-nor-leukotriene analogues. All four epoxides are formally derived from
Publikováno v:
Tetrahedron Letters. 31:7323-7326
A short, efficient and enantioselective synthesis of both (R) and (S) enantiomers of carnitine is reported starting with (R) or (S) malic acid and involving a chemoselective reduction step.
Publikováno v:
Journal of Heterocyclic Chemistry. 31:1121-1123
The protection of 2-substituted imidazole-5-methanol derivatives by tert-BDMS allowed the chlorination of the heterocycle in position 4 with good yield whereas direct chlorination on the imidazole alcohol was unsuccessful.