Zobrazeno 1 - 10
of 575
pro vyhledávání: '"P. Digard"'
A recent theory suggests that the evaporation kinetics of macromolecular solutions is insensitive to the ambient relative humidity (RH) due to the formation of a `polarisation layer' of solutes at the air-solution interface. We confirm this insensiti
Externí odkaz:
http://arxiv.org/abs/2211.16954
Autor:
A. E. Firth, B. W. Jagger, H. M. Wise, C. C. Nelson, K. Parsawar, N. M. Wills, S. Napthine, J. K. Taubenberger, P. Digard, J. F. Atkins
Publikováno v:
Open Biology, Vol 2, Iss 10 (2012)
Programmed ribosomal frameshifting is used in the expression of many virus genes and some cellular genes. In eukaryotic systems, the most well-characterized mechanism involves –1 tandem tRNA slippage on an X_XXY_YYZ motif. By contrast, the mechanis
Externí odkaz:
https://doaj.org/article/1012ec0bdaff4c22823ce4a2101b064a
Autor:
Ola Diebold, Shu Zhou, Colin Peter Sharp, Blanka Tesla, Hou Wei Chook, Paul Digard, Eleanor R. Gaunt
Publikováno v:
Viruses, Vol 16, Iss 9, p 1396 (2024)
RNA virus polymerases carry out multiple functions necessary for successful genome replication and transcription. A key tool for molecular studies of viral RNA-dependent RNA polymerases (RdRps) is a ‘minigenome’ or ‘minireplicon’ assay, in wh
Externí odkaz:
https://doaj.org/article/649d76dd16144eba9938d652aed9fa91
Autor:
Viola, I. M., Peterson, B., Pisetta, G., Pavar, G., Akhtar, H., Menoloascina, F., Mangano, E., Dunn, K. E., Gabl, R., Nila, A., Molinari, E., Cummins, C., Thompson, G., McDougall, C. M., Lo, T. Y. M., Denison, F. C., Digard, P., Malik, O., Dunn, M. J. G., Mehendale, F.
Publikováno v:
IEEE Open Journal of Engineering in Medicine and Biology, 2021
The SARS-CoV-2 virus is primarily transmitted through virus-laden fluid particles ejected from the mouth of infected people. Face covers can mitigate the risk of virus transmission but their outward effectiveness is not fully ascertained. Objective:
Externí odkaz:
http://arxiv.org/abs/2005.10720
Autor:
Jing Yang, Chunge Zhang, Yue Yuan, Ju Sun, Lu Lu, Honglei Sun, Heting Sun, Dong Chu, Siyuan Qin, Jianjun Chen, Chengbo Zhang, Xiyan Hao, Weifeng Shi, Wenjun Liu, George F. Gao, Paul Digard, Samantha Lycett, Yuhai Bi
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 6, Pp 1244-1249 (2023)
Two novel reassortant highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2 were identified in dead migratory birds in China in November 2021. The viruses probably evolved among wild birds through different flyways connecting Europe and A
Externí odkaz:
https://doaj.org/article/a6e279857e884b3f99a7776ddde82742
Autor:
Wenfang S Tan, Enguang Rong, Inga Dry, Simon G Lillico, Andy Law, Paul Digard, Bruce Whitelaw, Robert G Dalziel
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011822 (2023)
The advances in gene editing bring unprecedented opportunities in high throughput functional genomics to animal research. Here we describe a genome wide CRISPR knockout library, btCRISPRko.v1, targeting all protein coding genes in the cattle genome.
Externí odkaz:
https://doaj.org/article/9b23bb4e4bcd4b9fa5e52e039bc09552
Autor:
Hannah Goldswain, Xiaofeng Dong, Rebekah Penrice-Randal, Muhannad Alruwaili, Ghada T. Shawli, Tessa Prince, Maia Kavanagh Williamson, Jayna Raghwani, Nadine Randle, Benjamin Jones, I’ah Donovan-Banfield, Francisco J. Salguero, Julia A. Tree, Yper Hall, Catherine Hartley, Maximilian Erdmann, James Bazire, Tuksin Jearanaiwitayakul, Malcolm G. Semple, Peter J. M. Openshaw, J. Kenneth Baillie, ISARIC4C Investigators, Stevan R. Emmett, Paul Digard, David A. Matthews, Lance Turtle, Alistair C. Darby, Andrew D. Davidson, Miles W. Carroll, Julian A. Hiscox
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change in the spike protein,
Externí odkaz:
https://doaj.org/article/b3d75d58548e46f4b79481a60a9b08d2
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Fourth-generation ‘pod’ e-cigarette devices have been driven by technological advances in electronic atomization of the e-liquid. Use of microporous ceramic as a wicking material improves heating efficiency, but how it affects the chemic
Externí odkaz:
https://doaj.org/article/d1f15228f68440d1bd12afc1b63c4d18
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Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionWhile research shows no negative effects of bilingualism on autistic children’s development, due to misconceptions around both autism and bilingualism, bilingual parents and educational/clinical practitioners who advise them often expre
Externí odkaz:
https://doaj.org/article/21f3384681ca485da8a78c4cb2530eee