Zobrazeno 1 - 10
of 118
pro vyhledávání: '"P. Darwin Bell"'
Autor:
Naoe Harafuji, Chaozhe Yang, Maoqing Wu, Girija Thiruvengadam, Heather Gordish-Dressman, R. Griffin Thompson, P. Darwin Bell, Avi Z. Rosenberg, Claudia Dafinger, Max C. Liebau, Zsuzsanna Bebok, Ljubica Caldovic, Lisa M. Guay-Woodford
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Autosomal recessive polycystic kidney disease (ARPKD; MIM#263200) is a severe, hereditary, hepato-renal fibrocystic disorder that leads to early childhood morbidity and mortality. Typical forms of ARPKD are caused by pathogenic variants in the PKHD1
Externí odkaz:
https://doaj.org/article/30852107202d4088b3304c8e12f24d6b
Autor:
Yiming Zhang, Chaozhe Yang, Wei Wang, Naoe Harafuji, Piotr Stasiak, P. Darwin Bell, Ljuba Caldovic, Elizabeth Sztul, Lisa M. Guay-Woodford, Zsuzsanna Bebok
Autosomal recessive polycystic kidney disease (ARPKD) is caused primarily by mutations inPKHD1, encoding fibrocystin (FPC), butPkhd1mutant mice fail to express renal cystic disease. In contrast, the renal lesion inCys1cpk/cpk(cpk) mice with loss of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cef85368055265de676337fd3599e82
https://doi.org/10.1101/2022.04.19.488799
https://doi.org/10.1101/2022.04.19.488799
Autor:
Jifeng Huang, Zhang Li, Kurt A. Zimmerman, Dustin Z. Revell, Michal Mrug, Lan He, Gary Hardiman, Bradley K. Yoder, E. Starr Hazard, Wayne R. Fitzgibbon, P. Darwin Bell, Jung-Shan Hsu, Takamitsu Saigusa
Publikováno v:
Kidney360
Background Autosomal dominant polycystic kidney disease is caused by genetic mutations in PKD1 or PKD2. Macrophages and their associated inflammatory cytokines promote cyst progression; however, transcription factors within macrophages that control c
Autor:
Zhi-Ren Zhang, Wen-Feng Chu, Binlin Song, Monika Gooz, Jia-Ning Zhang, Chang-Jiang Yu, Shuai Jiang, Aleksander Baldys, Pal Gooz, Stacy Steele, Grzegorz Owsianik, Bernd Nilius, Peter Komlosi, P Darwin Bell
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73424 (2013)
Regulation of apical calcium entry is important for the function of principal cells of the collecting duct. However, the molecular identity and the regulators of the transporter/channel, which is responsible for apical calcium entry and what factors
Externí odkaz:
https://doaj.org/article/3615e0e3e7604edfa127137968810a84
Autor:
Josephine C. Adams, Irving H. Zucker, Sue C. Bodine, Kara Hansell Keehan, Heddwen L. Brooks, Thomas R. Kleyman, P. Darwin Bell, Morten B. Thomsen, Nigel W. Bunnett, Rory E. Morty, Jan-Marino Ramirez, Bina Joe, Bill J. Yates, André Marette
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Adams, J C & al., E 2020, ' An American Physiological Society cross-journal Call for Papers on "Deconstructing organs : Single-cell analyses, decellularized organs, organoids, and organ-on-a-chip models" ', AJP-Lung Cellular and Molecular Physiology . https://doi.org/10.1152/ajplung.00311.2020
Adams, J C & al., E 2020, ' An American Physiological Society cross-journal Call for Papers on "Deconstructing organs : Single-cell analyses, decellularized organs, organoids, and organ-on-a-chip models" ', AJP-Lung Cellular and Molecular Physiology . https://doi.org/10.1152/ajplung.00311.2020
[No abstract]
Autor:
Ben Fogelgren, Shin-Yi Lin, Xiaofeng Zuo, Kimberly M Jaffe, Kwon Moo Park, Ryan J Reichert, P Darwin Bell, Rebecca D Burdine, Joshua H Lipschutz
Publikováno v:
PLoS Genetics, Vol 7, Iss 4, p e1001361 (2011)
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of renal cysts that destroy the kidney. Mutations in PKD1 and PKD2, encoding polycystins-1 and -2, cause ADPKD. Polycystins are thought to function in primary cilia, b
Externí odkaz:
https://doaj.org/article/bf74d7c8e6ba44ebac1bf4f14b1c8970
Autor:
Gregory A. Michelotti, Wolfgang Liedtke, Mitzi Nagarkatti, Saurabh Chatterjee, Firas Alhasson, Varun Chandrashekaran, Prakash S. Nagarkatti, P. Darwin Bell, Ratanesh Seth, Diptadip Dattaroy, Suvarthi Das, Anna Mae Diehl
Publikováno v:
Free Radical Biology and Medicine. 102:260-273
NAFLD is a clinically progressive disease with steatosis, inflammation, endothelial dysfunction and fibrosis being the stages where clinical intervention becomes necessary. Lack of early biomarkers and absence of a FDA approved drug obstructs efforts
Publikováno v:
Am J Physiol Renal Physiol
Flow-related bending of cilia results in Ca2+ influx through a polycystin-1 (Pkd1) and polycystin-2 (Pkd2) complex, both of which are members of the transient receptor potential (TRP) family (TRPP1 and TRPP2, respectively). Deletion of this complex a
Publikováno v:
The FASEB Journal. 33
Autor:
Sylvie Mrug, Victor M. Darley-Usmar, P. Darwin Bell, Phillip Chumley, Stephen Barnes, Bradley K. Yoder, Anil K. Challa, Taylor F. Berryhill, Balu K. Chacko, Landon Wilson, Robert A. Kesterson, Juling Zhou, John M. Parant, Michal Mrug
Publikováno v:
American journal of physiology. Renal physiology. 316(3)
Deficiency in polycystin 1 triggers specific changes in energy metabolism. To determine whether defects in other human cystoproteins have similar effects, we studied extracellular acidification and glucose metabolism in human embryonic kidney (HEK-29