Zobrazeno 1 - 10
of 164
pro vyhledávání: '"P. Dan Cook"'
Publikováno v:
CivilEng, Vol 4, Iss 1, Pp 224-247 (2023)
The penetration of ions plays an important role in the durability of concrete structures. This study aims to establish the feasibility of using dental X-ray equipment to measure the concentration and penetration of iodide within cementitious systems.
Externí odkaz:
https://doaj.org/article/07f054e7c5b14d3db3b835533b5b9057
Autor:
Anna Avroutskaya, Henri Sasmor, Rudy L. Juliano, Jeffrey A. Hughes, Charles J. Guinosso, P. Dan Cook
Publikováno v:
Delivery Strategies for Antisense Oligonucleotide Therapeutics ISBN: 9781315150901
Antisense and antigene oligonucleotides offer a promising new approach for therapy of cancer, inflammatory diseases, and viral diseases. Due to the large molecular weight and polar nature of oligonucleotides, cellular uptake is potentially the limiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f962282dd49285ba911b409dc026ca3
https://doi.org/10.1201/9781315150901-12
https://doi.org/10.1201/9781315150901-12
Autor:
Nicholas A. Boyle, Jennifer L. Brooks, Patrick Fagan, John S. Lambert, Marija Prhavc, P. Dan Cook
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 24:1651-1664
Nucleoside reverse transcriptase inhibitors (NRTIs) are prodrugs which require three intracellular phosphorylation steps to yield their corresponding, biologically active, nucleoside triphosphate. In order to circumvent this often inefficient phospho
Autor:
P. Dan Cook, Kandasamy Sakthivel
Publikováno v:
Synlett. 2005:1586-1590
A facile and efficient methodology is described for the synthesis of 3-fluoro-3-deazaguanosines based on a novel electrophilic fluorination of 5-(cyanomethyl)imidazole-4-carboxylate nucleosides. This general methodology can be readily applied to the
Autor:
P. Dan Cook, Kandasamy Sakthivel
Publikováno v:
Tetrahedron Letters. 46:3883-3887
This paper describes the ready preparation of 3,6-difluoro-3-deazapurine (4,7-difluoroimidazo[4,5-c]pyridine). This novel base was glycosylated under mild conditions using three different ribose sugar analogs. 3,6-Difluoro-3-deazapurine ribonucleosid
Autor:
Guangyi Wang, Marija Prhavc, Jennifer L. Brooks, Tiffany Hurd, P. Dan Cook, Vivek K. Rajwanshi, Patrick Fagan
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 24:179-189
3'-Azido-3',5-dideoxythymidine 5'-phosphonate and 3',5'-dideoxy-5'-difluoromethylenethymidine 5'-phosphonate were prepared by multistep syntheses. The nucleoside 5'-phosphonates were converted to their triphosphates and triphosphate mimics (P3Ms) con
Autor:
P. Dan Cook, Thazha P. Prakash, Balkrishen Bhat, David B. Olsen, Malcolm MacCoss, Joanne E Tomassini, Sheila M Galloway, Mark W Stahlhut, Marija Prhavc, Catherine Hilliard, Steven S. Carroll, Anne B. Eldrup
Publikováno v:
Journal of Medicinal Chemistry. 48:1199-1210
Several triphosphates of modified nucleosides (1-6) were identified as inhibitors (IC(50) = 0.08-3.8 microM) of hepatitis C virus RNA-dependent RNA polymerase (RdRp). Although the initial SAR developed by determining the ability of the triphosphates
Autor:
Michele Bosserman, Neelima Bhat, Joanne E Tomassini, Sanjib Bera, Marija Prhavc, Christine Burlein, Malcolm MacCoss, Charles R. Allerson, Jennifer L. Brooks, David B. Olsen, Jie Xia, Balkrishen Bhat, C. Frank Bennett, Steven S. Carroll, P. Dan Cook, Quanlai Song, Krista Getty, Anne B. Eldrup, Daniel R. McMasters, Thazha P. Prakash
Publikováno v:
Journal of Medicinal Chemistry. 47:2283-2295
As part of a continued effort to identify inhibitors of hepatitis C viral (HCV) replication, we report here the synthesis and evaluation of a series of nucleoside analogues and their corresponding triphosphates. Nucleosides were evaluated for their a
Publikováno v:
Tetrahedron Letters. 41:9967-9971
A stereoselective synthesis of 3′-deoxy-3′-C-formyl-5-methyluridine 2 is described via the dithiane 4 as the key intermediate. Compound 2 was coupled with 3 into a novel ribo-MMI dimer 1. The dimer was then incorporated into antisense oligonucleo
Publikováno v:
Tetrahedron Letters. 41:7813-7816
The synthesis of novel 5′-DMT- and 5′-MMT-protected 3′-methylene H-phosphonate thymidines 1 – 6 , having methoxy, fluoro, hydrogen, and methoxyethoxy substituents at the 2′-position is reported.