Zobrazeno 1 - 10
of 1 553
pro vyhledávání: '"P. Dalley"'
Autor:
Lingchen Liu, Jia Zhang, Scott Wood, Felicity Newell, Conrad Leonard, Lambros T. Koufariotis, Katia Nones, Andrew J. Dalley, Haarika Chittoory, Farzad Bashirzadeh, Jung Hwa Son, Daniel Steinfort, Jonathan P. Williamson, Michael Bint, Carl Pahoff, Phan T. Nguyen, Scott Twaddell, David Arnold, Christopher Grainge, Peter T. Simpson, David Fielding, Nicola Waddell, John V. Pearson
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Lung cancer is a heterogeneous disease and the primary cause of cancer-related mortality worldwide. Somatic mutations, including large structural variants, are important biomarkers in lung cancer for selecting targeted therapy. Ge
Externí odkaz:
https://doaj.org/article/3e541a9800144058a28c32a39366caaa
Autor:
Olga Gliko, Matt Mallory, Rachel Dalley, Rohan Gala, James Gornet, Hongkui Zeng, Staci A. Sorensen, Uygar Sümbül
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Neuronal anatomy is central to the organization and function of brain cell types. However, anatomical variability within apparently homogeneous populations of cells can obscure such insights. Here, we report large-scale automation of neurona
Externí odkaz:
https://doaj.org/article/9d37f38af6ee4db2a8caf15cd724e3bd
Autor:
Sandy Rao, Gina Dimitropoulos, Rae Jardine, Julien Quickstad, Laetitia Satam, Mohammad Qureshi, Thyra Bui, Antoaneta Alexandrova Todorova, Ysabelle Tumaneng, Abitha Suthakaran, Kaiden Dalley, Stacie Smith, Scott B. Patten, the entire HEARTS Study Team
Publikováno v:
Research Involvement and Engagement, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Background This manuscript is coauthored by 15 young adult Patient RESearch partners (PARES) with lived and living mental health experiences and three institutional researchers across Canada involved in a patient-oriented research (POR) stud
Externí odkaz:
https://doaj.org/article/44d1655041a64626aa4da03ede34e64f
Autor:
Nikolai C. Dembrow, Scott Sawchuk, Rachel Dalley, Ximena Opitz-Araya, Mark Hudson, Cristina Radaelli, Lauren Alfiler, Sarah Walling-Bell, Darren Bertagnolli, Jeff Goldy, Nelson Johansen, Jeremy A. Miller, Kamiliam Nasirova, Scott F. Owen, Alejandro Parga-Becerra, Naz Taskin, Michael Tieu, David Vumbaco, Natalie Weed, Julia Wilson, Brian R. Lee, Kimberly A. Smith, Staci A. Sorensen, William J. Spain, Ed S. Lein, Steve I. Perlmutter, Jonathan T. Ting, Brian E. Kalmbach
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114718- (2024)
Summary: Large-scale analysis of single-cell gene expression has revealed transcriptomically defined cell subclasses present throughout the primate neocortex with gene expression profiles that differ depending upon neocortical region. Here, we test w
Externí odkaz:
https://doaj.org/article/f682c29824904980a5a21055862f0370
Autor:
Arun Jyothidasan, Sini Sunny, Asokan Devarajan, Aniqa Sayed, John Kofi Afortude, Brian Dalley, Vivek Nanda, Steven Pogwizd, Silvio H. Litovsky, Joel D. Trinity, Matthew Might, Namakkal S. Rajasekaran
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103263- (2024)
The endoplasmic reticulum (ER) regulates protein folding and maintains proteostasis in cells. We observed that the ER transcriptome is impaired during chronic reductive stress (RS) in cardiomyocytes. Here, we hypothesized that a prolonged moderate tr
Externí odkaz:
https://doaj.org/article/89d8b21237c04432b90821ae7822b5b0
Autor:
Elena Martín-González, Ángeles Prados-Pardo, Stephen J. Sawiak, Jeffrey W. Dalley, Daniel Padro, Pedro Ramos-Cabrer, Santiago Mora, Margarita Moreno-Montoya
Publikováno v:
Behavioral and Brain Functions, Vol 19, Iss 1, Pp 1-15 (2023)
Abstract Compulsivity is considered a transdiagnostic dimension in obsessive–compulsive and related disorders, characterized by heterogeneous cognitive and behavioral phenotypes associated with abnormalities in cortico-striatal-thalamic-cortical ci
Externí odkaz:
https://doaj.org/article/e5f202b4047b401da33ed3dec68e0291
Publikováno v:
Resuscitation Plus, Vol 17, Iss , Pp 100535- (2024)
Background: A respiratory function monitor (RFM) gives immediate feedback, allowing clinicians to adjust face mask ventilation to correct leak or inappropriate tidal volumes. We audited the satisfaction of clinicians with a neonatal resuscitation tra
Externí odkaz:
https://doaj.org/article/b14240ee181c4821aea03cb78513f39c
Autor:
Jacob A. Stern, Tyler J. Free, Kimberlee L. Stern, Spencer Gardiner, Nicholas A. Dalley, Bradley C. Bundy, Joshua L. Price, David Wingate, Dennis Della Corte
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Various approaches have used neural networks as probabilistic models for the design of protein sequences. These "inverse folding" models employ different objective functions, which come with trade-offs that have not been assessed in detail b
Externí odkaz:
https://doaj.org/article/bfdd2c95245d460e8f802e7b5da5c735
Autor:
Riccardo Dore, Laura Watson, Stefanie Hollidge, Christin Krause, Sarah Christine Sentis, Rebecca Oelkrug, Cathleen Geißler, Kornelia Johann, Mehdi Pedaran, Greta Lyons, Nuria Lopez-Alcantara, Julia Resch, Friedhelm Sayk, Karl Alexander Iwen, Andre Franke, Teide Jens Boysen, Jeffrey W. Dalley, Kristina Lorenz, Carla Moran, Kirsten L. Rennie, Anders Arner, Henriette Kirchner, Krishna Chatterjee, Jens Mittag
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart. Surprisingly, we report that treatment of RTHα pat
Externí odkaz:
https://doaj.org/article/39463f62342d495e8fd52912473497e2
Autor:
Katharina Zühlsdorff, Juan Verdejo-Román, Luke Clark, Natalia Albein-Urios, Carles Soriano-Mas, Rudolf N. Cardinal, Trevor W. Robbins, Jeffrey W. Dalley, Antonio Verdejo-García, Jonathan W. Kanen
Publikováno v:
BJPsych Open, Vol 10 (2024)
Background Individuals with cocaine use disorder or gambling disorder demonstrate impairments in cognitive flexibility: the ability to adapt to changes in the environment. Flexibility is commonly assessed in a laboratory setting using probabilistic r
Externí odkaz:
https://doaj.org/article/f7034e70efe3417a95e07f4d68a79c04