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Akademický článek

The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation

Autor: Khurts Shilagardi, Eric D. Spear, Rachy Abraham, Diane E. Griffin, Susan Michaelis

Publikováno v: mBio, Vol 13, Iss 5 (2022)

ABSTRACT COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a devastating impact on global public health, emphasizing the importance of understanding innate immune mechanisms and cellular restriction fact

Externí odkaz: https://doaj.org/article/c3bddbb4b2ae4aeaae5dc293fc31dd8b

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Akademický článek

A recrystallization heat-treatment to reduce deformation anisotropy of additively manufactured Inconel 718

Autor: Nadia Kouraytem, John Varga, Behnam Amin-Ahmadi, Hadi Mirmohammad, Raphaël A. Chanut, Ashley D. Spear, Owen T. Kingstedt

Publikováno v: Materials & Design, Vol 198, Iss , Pp 109228- (2021)

The aim of the current study is to investigate the suitability of a solutionizing recrystallization (RC) heat-treatment to improve the yield strength of laser powder-bed fusion (L-PBF) Inconel 718 (IN718), while decreasing deformation anisotropy unde

Externí odkaz: https://doaj.org/article/d9bc64fad7fe4c5bb85201817ac3501c

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Akademický článek

Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24.

Autor: Kaitlin M Wood, Eric D Spear, Otto W Mossberg, Kamsi O Odinammadu, Wenxin Xu, Susan Michaelis

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0239269 (2020)

The integral membrane zinc metalloprotease ZMPSTE24 plays a key role in the proteolytic processing of farnesylated prelamin A, the precursor of the nuclear scaffold protein lamin A. Failure of this processing step results in the accumulation of perma

Externí odkaz: https://doaj.org/article/1f96605783564ba7a48691bdbf9508b8

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Akademický článek

Reconstructed and analyzed X-ray computed tomography data of investment-cast and additive-manufactured aluminum foam for visualizing ligament failure mechanisms and regions of contact during a compression test

Autor: Kristoffer E. Matheson, Kory K. Cross, Matthew M. Nowell, Ashley D. Spear

Publikováno v: Data in Brief, Vol 16, Iss , Pp 601-603 (2018)

Three stochastic open-cell aluminum foam samples were incrementally compressed and imaged using X-ray Computed Tomography (CT). One of the samples was created using conventional investment casting methods and the other two were replicas of the same f

Externí odkaz: https://doaj.org/article/4bb75470148845b8a682f55d81dc54af

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Akademický článek

Degradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast

Autor: Matthew J. Maurer, Eric D. Spear, Allen T. Yu, Evan J. Lee, Saba Shahzad, Susan Michaelis

Publikováno v: G3: Genes, Genomes, Genetics, Vol 6, Iss 7, Pp 1853-1866 (2016)

Cellular protein quality control (PQC) systems selectively target misfolded or otherwise aberrant proteins for degradation by the ubiquitin-proteasome system (UPS). How cells discern abnormal from normal proteins remains incompletely understood, but

Externí odkaz: https://doaj.org/article/9571fcb8f00742279e74293c8a95de0a

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Akademický článek

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability

Autor: Eric D. Spear, Erh-Ting Hsu, Laiyin Nie, Elisabeth P. Carpenter, Christine A. Hrycyna, Susan Michaelis

Publikováno v: Disease Models & Mechanisms, Vol 11, Iss 7 (2018)

The human zinc metalloprotease ZMPSTE24 is an integral membrane protein crucial for the final step in the biogenesis of the nuclear scaffold protein lamin A, encoded by LMNA. After farnesylation and carboxyl methylation of its C-terminal CAAX motif,

Externí odkaz: https://doaj.org/article/6c0979a4e97a4be383f99598cba015bf

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Functional plasticity in extrastriate visual cortex following neonatal visual cortex damage and monocular enucleation

Autor: K R, Illig, Y P, Danilov, A, Ahmad, C B, Kim, P D, Spear

Publikováno v: Brain research. 882(1-2)

Neonatal lesions of primary visual cortex (areas 17, 18 and 19; VC) in cats lead to significant changes in the organization of visual pathways, including severe retrograde degeneration of retinal ganglion cells of the X/beta class. Cells in posterome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b40af0b1c9300800f4adfc89313df242
https://pubmed.ncbi.nlm.nih.gov/11056208

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Effects of aging on numbers and sizes of neurons in histochemically defined subregions of monkey striate cortex

Autor: C B, Kim, L P, Pier, P D, Spear

Publikováno v: The Anatomical record. 247(1)

In addition to its horizontal layers, primate striate cortex has a vertical modular organization. Among the vertical modules are histochemically defined areas of high and low cytochrome oxidase labeling in the supragranular layers, referred to, respe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a888c48efa0c7c9897599d523b87550
https://pubmed.ncbi.nlm.nih.gov/8986309

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