Zobrazeno 1 - 10
of 16
pro vyhledávání: '"P. D. Reaven"'
Autor:
Jie Huang, Jennifer E. Huffman, Yunfeng Huang, Ítalo Do Valle, Themistocles L. Assimes, Sridharan Raghavan, Benjamin F. Voight, Chang Liu, Albert-László Barabási, Rose D. L. Huang, Qin Hui, Xuan-Mai T. Nguyen, Yuk-Lam Ho, Luc Djousse, Julie A. Lynch, Marijana Vujkovic, Catherine Tcheandjieu, Hua Tang, Scott M. Damrauer, Peter D. Reaven, Donald Miller, Lawrence S. Phillips, Maggie C. Y. Ng, Mariaelisa Graff, Christopher A. Haiman, Ruth J. F. Loos, Kari E. North, Loic Yengo, George Davey Smith, Danish Saleheen, J. Michael Gaziano, Daniel J. Rader, Philip S. Tsao, Kelly Cho, Kyong-Mi Chang, Peter W. F. Wilson, VA Million Veteran Program, Yan V. Sun, Christopher J. O’Donnell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Elevated body mass index is heritable and associated with many health conditions that impact morbidity and mortality. Here, the authors identify greater than 900 genetic loci for body mass index (BMI) and find over 300 diagnoses associated with incre
Externí odkaz:
https://doaj.org/article/06e868b6d30b40ac93e6e40a0445cc48
Autor:
Megan M. Shuey, Kyung Min Lee, Jacob Keaton, Nikhil K. Khankari, Joseph H. Breeyear, Venexia M. Walker, Donald R. Miller, Kent R. Heberer, Peter D. Reaven, Shoa L. Clarke, Jennifer Lee, Julie A. Lynch, Marijana Vujkovic, Todd L. Edwards
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104674- (2023)
Summary: Background: The identification of new uses for existing drug therapies has the potential to identify treatments for comorbid conditions that have the added benefit of glycemic control while also providing a rapid, low-cost approach to drug (
Externí odkaz:
https://doaj.org/article/0a32e0fd304d4bea90a5c225732f57ca
Publikováno v:
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-9 (2021)
Abstract Aims Low C-peptide levels, indicating beta-cell dysfunction, are associated with increased within-day glucose variation and hypoglycemia. In advanced type 2 diabetes, severe hypoglycemia and increased glucose variation predict cardiovascular
Externí odkaz:
https://doaj.org/article/657936416ccc43ddb121d182fc58db61
Autor:
Juraj Koska, Jeremy Furtado, Yueming Hu, Shripad Sinari, Matthew J. Budoff, Dean Billheimer, Dobrin Nedelkov, Robyn L. McClelland, Peter D. Reaven
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 9, Pp 100263- (2022)
Apolipoproteins (apo) C-I and C-II are key regulators of triglyceride and HDL metabolism. Both exist as full-size native and truncated (apoC-I'; apoC-II') posttranslational proteoforms. However, the determinants and the role of these proteoforms in l
Externí odkaz:
https://doaj.org/article/0cf7694d622b441b87f717b7082920e1
Autor:
Nikhil K. Khankari, Jacob M. Keaton, Venexia M. Walker, Kyung Min Lee, Megan M. Shuey, Shoa L. Clarke, Kent R. Heberer, Donald R. Miller, Peter D. Reaven, Julie A. Lynch, Marijana Vujkovic, Todd L. Edwards
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104038- (2022)
Summary: Background: Maintaining a healthy lifestyle to reduce type 2 diabetes (T2D) risk is challenging and additional strategies for T2D prevention are needed. We evaluated several lipid control medications as potential therapeutic options for T2D
Externí odkaz:
https://doaj.org/article/40b062220d4c4983bd63137c4ba814a9
Autor:
Marina Serper, Marijana Vujkovic, David E Kaplan, Rotonya M Carr, Kyung Min Lee, Qing Shao, Donald R Miller, Peter D Reaven, Lawrence S Phillips, Christopher J O'Donnell, James B Meigs, Peter W F Wilson, Rachel Vickers-Smith, Henry R Kranzler, Amy C Justice, John M Gaziano, Sumitra Muralidhar, Saiju Pyarajan, Scott L DuVall, Themistocles L Assimes, Jennifer S Lee, Philip S Tsao, Daniel J Rader, Scott M Damrauer, Julie A Lynch, Danish Saleheen, Benjamin F Voight, Kyong-Mi Chang, VA Million Veteran Program
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237430 (2020)
Background & aimsGiven ongoing challenges in non-invasive non-alcoholic liver disease (NAFLD) diagnosis, we sought to validate an ALT-based NAFLD phenotype using measures readily available in electronic health records (EHRs) and population-based stud
Externí odkaz:
https://doaj.org/article/6b22e0279c39480fb539751b81449be2
Autor:
Juraj Koska, Hussein Yassine, Olgica Trenchevska, Shripad Sinari, Dawn C. Schwenke, Frances T. Yen, Dean Billheimer, Randall W. Nelson, Dobrin Nedelkov, Peter D. Reaven
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 5, Pp 894-905 (2016)
The apoC-III proteoform containing two sialic acid residues (apoC-III2) has different in vitro effects on lipid metabolism compared with asialylated (apoC-III0) or the most abundant monosialylated (apoC-III1) proteoforms. Cross-sectional and longitud
Externí odkaz:
https://doaj.org/article/d090ab72382943adb80576d75f82fe1e
Autor:
Hussein N Yassine, Olgica Trenchevska, Ambika Ramrakhiani, Aarushi Parekh, Juraj Koska, Ryan W Walker, Dean Billheimer, Peter D Reaven, Frances T Yen, Randall W Nelson, Michael I Goran, Dobrin Nedelkov
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144138 (2015)
Apolipoprotein C-III (apoC-III) regulates triglyceride (TG) metabolism. In plasma, apoC-III exists in non-sialylated (apoC-III0a without glycosylation and apoC-III0b with glycosylation), monosialylated (apoC-III1) or disialylated (apoC-III2) proteofo
Externí odkaz:
https://doaj.org/article/4263e407812d451db09dac2570d33695
Autor:
Hussein N Yassine, Olgica Trenchevska, Huijuan He, Chad R Borges, Dobrin Nedelkov, Wendy Mack, Naoko Kono, Juraj Koska, Peter D Reaven, Randall W Nelson
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0115320 (2015)
Using mass spectrometric immunoassay, the abundance of SAA truncations relative to the native variants was examined in plasma of 91 participants with type 2 diabetes and chronic kidney disease and 69 participants without diabetes.The ratio of SAA 1.1
Externí odkaz:
https://doaj.org/article/d0938a116c82448d9396a5fa1e7ffe10
Autor:
John M. Hayden, Libuse Brachova, Karen Higgins, Lewis Obermiller, Alex Sevanian, Srikrishna Khandrika, Peter D. Reaven
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 1, Pp 26-35 (2002)
Oxidized LDL (OxLDL) is composed of many potentially proatherogenic molecules, including oxysterols. Of the oxysterols, 7-ketocholesterol (7-KC) is found in relatively large abundance in OxLDL, as well as in atherosclerotic plaque and foam cells in v
Externí odkaz:
https://doaj.org/article/5b4741c2cddf4a9f8be40086864adebd