Zobrazeno 1 - 10
of 630
pro vyhledávání: '"P. D. KLEIN"'
Autor:
Michiel Vanneste, Hanne Hoskens, Seppe Goovaerts, Harold Matthews, Jay Devine, Jose D. Aponte, Joanne Cole, Mark Shriver, Mary L. Marazita, Seth M. Weinberg, Susan Walsh, Stephen Richmond, Ophir D. Klein, Richard A. Spritz, Hilde Peeters, Benedikt Hallgrímsson, Peter Claes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Human craniofacial shape is highly variable yet highly heritable with numerous genetic variants interacting through multiple layers of development. Here, we hypothesize that Mendelian phenotypes represent the extremes of a phenotypic spectru
Externí odkaz:
https://doaj.org/article/53249a4e52054d56af916527ff5bdc39
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Contending with discrimination can yield a cascade of negative psychological and physiological outcomes which adversely affect health. How individuals manage their emotions in response to discrimination can influence the extent of these nega
Externí odkaz:
https://doaj.org/article/94125d08847c4c9f97d8e213209775b5
Autor:
Zachary T. Calamari, Andrew Song, Emily Cohen, Muspika Akter, Rishi Das Roy, Outi Hallikas, Mona M. Christensen, Pengyang Li, Pauline Marangoni, Jukka Jernvall, Ophir D. Klein
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background Continuously growing teeth are an important innovation in mammalian evolution, yet genetic regulation of continuous growth by stem cells remains incompletely understood. Dental stem cells responsible for tooth crown growth are los
Externí odkaz:
https://doaj.org/article/7016d160d0634ccd86d7e97904abdff2
Publikováno v:
JPRAS Open, Vol 43, Iss , Pp 133-139 (2025)
Introduction: Silver sulfadiazine 1 % cream had historically been the mainstay initial treatment for scald wounds at our institution. However, we transitioned to using closed dressings of only petrolatum-impregnated 3 % bismuth tribromophenate gauze
Externí odkaz:
https://doaj.org/article/c9ad4d959a8146088fe586bdc0cb4e12
Autor:
Gisela Altés, Anna Olomí, Aida Perramon-Güell, Sara Hernández, Anna Casanovas, Aurora Pérez, Juan Miguel Díaz-Tocados, José Manuel Valdivielso, Cristina Megino, Raúl Navaridas, Xavier Matias-Guiu, Ophir D. Klein, Joaquim Egea, Xavi Dolcet, Andrée Yeramian, Mario Encinas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Genes of the Sprouty family (Spry1-4) are feedback inhibitors of receptor tyrosine kinases, especially of Ret and the FGF receptors. As such, they play distinct and overlapping roles in embryo morphogenesis and are considered to be tumor sup
Externí odkaz:
https://doaj.org/article/c35f82b053404988a6db6232e37d7598
Autor:
Alison D. Klein, Michael Overholtzer
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Much is still unknown about microautophagy and its regulators. In our recent paper, one such regulator of microautophagy, the lipid kinase PIKfyve, is described. Previously it was found that treating cells with agents like lysomotropic drugs or proto
Externí odkaz:
https://doaj.org/article/745bccee7e2247d3be4ac9188a3449b3
Autor:
Saeka Rahman, Md Motiur Rahman, Miad Faezipour, Mo Rastgaar, Elika Ridelman, Justin D. Klein, Beth A. Angst, Christina M. Shanti
Publikováno v:
IEEE Access, Vol 12, Pp 147249-147268 (2024)
Burn injuries present a substantial global public health challenge. The conventional approach, relying on visual inspection to compute total body surface area (TBSA) for assessing burn severity, encounters the inherent limitations of proper estimatio
Externí odkaz:
https://doaj.org/article/92929069f6354d10999fee841f6bb460
Autor:
Michelle L. March, MD, MPH, Andrea R. Meisman, MA, Matthew W. Zackoff, MD, MEd, Melissa D. Klein, MD, MEd, Francis J. Real, MD, MEd
Publikováno v:
Journal of Pediatrics: Clinical Practice, Vol 12, Iss , Pp 200099- (2024)
To assess caregivers’ and community members’ perspectives on a potential communication framework for pediatricians to provide firearm safety counseling in primary care via focus groups. Participants recommended embedding the topic within injury p
Externí odkaz:
https://doaj.org/article/d8e9f09b30874a899e51efeb892ca3ac
Autor:
Wei Du, Adya Verma, Qianlin Ye, Wen Du, Sandy Lin, Atsushi Yamanaka, Ophir D Klein, Jimmy K Hu
Publikováno v:
PLoS Genetics, Vol 20, Iss 6, p e1011326 (2024)
The development of ectodermal organs begins with the formation of a stratified epithelial placode that progressively invaginates into the underlying mesenchyme as the organ takes its shape. Signaling by secreted molecules is critical for epithelial m
Externí odkaz:
https://doaj.org/article/d38b9ae49d034e0a9df54926422d4e30
Autor:
Hyun-Yi Kim, Victoria Cooley, Eun-Jung Kim, Shujin Li, Jong-Min Lee, Dina Sheyfer, Wenjun Liu, Ophir D. Klein, Derk Joester, Han-Sung Jung
Publikováno v:
International Journal of Oral Science, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Ameloblasts are specialized cells derived from the dental epithelium that produce enamel, a hierarchically structured tissue comprised of highly elongated hydroxylapatite (OHAp) crystallites. The unique function of the epithelial cells synth
Externí odkaz:
https://doaj.org/article/69f72bb2aa6741ab8928e95c641fc3f5