Zobrazeno 1 - 10
of 633
pro vyhledávání: '"P. D. KLEIN"'
Autor:
Gisela Altés, Anna Olomí, Aida Perramon-Güell, Sara Hernández, Anna Casanovas, Aurora Pérez, Juan Miguel Díaz-Tocados, José Manuel Valdivielso, Cristina Megino, Raúl Navaridas, Xavier Matias-Guiu, Ophir D. Klein, Joaquim Egea, Xavi Dolcet, Andrée Yeramian, Mario Encinas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Genes of the Sprouty family (Spry1-4) are feedback inhibitors of receptor tyrosine kinases, especially of Ret and the FGF receptors. As such, they play distinct and overlapping roles in embryo morphogenesis and are considered to be tumor sup
Externí odkaz:
https://doaj.org/article/c35f82b053404988a6db6232e37d7598
Autor:
Alison D. Klein, Michael Overholtzer
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Much is still unknown about microautophagy and its regulators. In our recent paper, one such regulator of microautophagy, the lipid kinase PIKfyve, is described. Previously it was found that treating cells with agents like lysomotropic drugs or proto
Externí odkaz:
https://doaj.org/article/745bccee7e2247d3be4ac9188a3449b3
Autor:
Wei Du, Adya Verma, Qianlin Ye, Wen Du, Sandy Lin, Atsushi Yamanaka, Ophir D Klein, Jimmy K Hu
Publikováno v:
PLoS Genetics, Vol 20, Iss 6, p e1011326 (2024)
The development of ectodermal organs begins with the formation of a stratified epithelial placode that progressively invaginates into the underlying mesenchyme as the organ takes its shape. Signaling by secreted molecules is critical for epithelial m
Externí odkaz:
https://doaj.org/article/d38b9ae49d034e0a9df54926422d4e30
Autor:
Saeka Rahman, Md Motiur Rahman, Miad Faezipour, Mo Rastgaar, Elika Ridelman, Justin D. Klein, Beth A. Angst, Christina M. Shanti
Publikováno v:
IEEE Access, Vol 12, Pp 147249-147268 (2024)
Burn injuries present a substantial global public health challenge. The conventional approach, relying on visual inspection to compute total body surface area (TBSA) for assessing burn severity, encounters the inherent limitations of proper estimatio
Externí odkaz:
https://doaj.org/article/92929069f6354d10999fee841f6bb460
Autor:
Hyun-Yi Kim, Victoria Cooley, Eun-Jung Kim, Shujin Li, Jong-Min Lee, Dina Sheyfer, Wenjun Liu, Ophir D. Klein, Derk Joester, Han-Sung Jung
Publikováno v:
International Journal of Oral Science, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Ameloblasts are specialized cells derived from the dental epithelium that produce enamel, a hierarchically structured tissue comprised of highly elongated hydroxylapatite (OHAp) crystallites. The unique function of the epithelial cells synth
Externí odkaz:
https://doaj.org/article/69f72bb2aa6741ab8928e95c641fc3f5
Autor:
A. Schneibel, M. Gähler, M. Halbgewachs, R. Berger, J. Brauchle, M. Geßner, V. Gstaiger, D. Hein, C. Henry, N. Merkle, D. Klein
Publikováno v:
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Vol XLVIII-M-1-2023, Pp 579-586 (2023)
In the early morning hours on Tuesday, February 6, 2023, the southern part of Türkiye was struck by two large and several smaller earthquakes, causing destruction and casualties over a remarkably large area. In such cases, quick response and well-in
Externí odkaz:
https://doaj.org/article/5320abc726ad49c1b57d19f3d7190d09
Autor:
Macarena Las Heras, Benjamín Szenfeld, Rami A. Ballout, Emanuele Buratti, Silvana Zanlungo, Andrea Dardis, Andrés D. Klein
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Niemann-Pick type C (NPC) disease is a lysosomal storage disease (LSD) characterized by the buildup of endo-lysosomal cholesterol and glycosphingolipids due to loss of function mutations in the NPC1 and NPC2 genes. NPC patients can present w
Externí odkaz:
https://doaj.org/article/32dbaaaf5f05426697b283303572d116
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Intracellular pH dynamics is increasingly recognized to regulate myriad cell behaviors. We report a finding that intracellular pH dynamics also regulates adult stem cell lineage specification. We identify an intracellular pH gradient in mous
Externí odkaz:
https://doaj.org/article/323bed6f592141a5814fab16eae5c3d2
Autor:
Juliana D. Klein, Simo N. Maduna, Matthew L. Dicken, Charlene daSilva, Michelle Soekoe, Meaghen E. McCord, Warren M. Potts, Snorre B. Hagen, Aletta E. Bester‐van der Merwe
Publikováno v:
Evolutionary Applications, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract Adaptive divergence in response to environmental clines are expected to be common in species occupying heterogeneous environments. Despite numerous advances in techniques appropriate for non‐model species, gene–environment association st
Externí odkaz:
https://doaj.org/article/23ca8294b8c745b78c0c2b164c170f8f
Autor:
David J. Estrin, Julianna M. Kulik, Nicholas J. Beacher, Anthony P. Pawlak, Samuel D. Klein, Mark O. West
Publikováno v:
Addiction Neuroscience, Vol 8, Iss , Pp 100121- (2023)
Resumption of drug taking is a primary focus for substance use disorder research and can be triggered by drug-associated environmental stimuli. The Nucleus Accumbens (NAc) is a key brain region which guides motivated behavior and is implicated in res
Externí odkaz:
https://doaj.org/article/e0cab2f25f2746bcad346a52c221e1e2