Zobrazeno 1 - 10
of 215
pro vyhledávání: '"P. Cmielewski"'
Autor:
How, Ying Ying, Reyne, Nicole, Croughan, Michelle K., Cmielewski, Patricia, Batey, Daniel, Costello, Lucy F., Smith, Ronan, Ahlers, Jannis N., Cholewa, Marian, Kolodziej, Magdalena, Duerr, Julia, Mall, Marcus A., Kitchen, Marcus J., Asselin-Labat, Marie-Liesse, Paganin, David M., Donnelley, Martin, Morgan, Kaye S.
X-ray dark-field imaging is well-suited to visualizing the health of the lungs because the alveoli create a strong dark-field signal. However, time-resolved and tomographic (i.e., 4D) dark-field imaging is challenging, since most x-ray dark-field tec
Externí odkaz:
http://arxiv.org/abs/2411.14669
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Cystic Fibrosis (CF) is caused by a defect in the CF transmembrane conductance regulator (CFTR) gene responsible for epithelial ion transport. Nasal potential difference (PD) measurement is a well established diagnostic technique for assessing the ef
Externí odkaz:
https://doaj.org/article/c29d054c41364c14879b128ef5bb1c62
Autor:
Stephanie A. Harker, Melissa Preissner, Rachel Yoon Chang, David Trevascus, Chengxi Liu, Yuncheng Wang, Michael Y. T. Chow, Patricia Cmielewski, Nicole Reyne, Ying Ying How, James A. Pollock, Mitzi Klein, Christopher A. Wright, Stephen Dubsky, Martin Donnelley, Hak-Kim Chan, Kaye S. Morgan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Phase contrast x-ray imaging (PCXI) provides high-contrast images of weakly-attenuating structures like the lungs. PCXI, when paired with 4D X-ray Velocimetry (XV), can measure regional lung function and non-invasively assess the efficacy of
Externí odkaz:
https://doaj.org/article/6cf4a8b566d54d9aab3793f39b9ef0a5
Autor:
Nicole Reyne, Ronan Smith, Patricia Cmielewski, Nina Eikelis, Mark Lawrence, Jennie Louise, Piraveen Pirakalathanan, David Parsons, Martin Donnelley
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Two cystic fibrosis (CF) rat models, one carrying the common Phe508del mutation and the other a nonsense cystic fibrosis transmembrane conductance regulator (CFTR) mutation (knockout) were previously characterised. Although relevant CFTR mRN
Externí odkaz:
https://doaj.org/article/f30e6698146645fa9909c5f556e1586c
Autor:
Jiraporn Ousingsawat, Raquel Centeio, Nicole Reyne, Alexandra McCarron, Patricia Cmielewski, Rainer Schreiber, Gabriella diStefano, Dorothee Römermann, Ursula Seidler, Martin Donnelley, Karl Kunzelmann
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in secretory epithelial cells of airways and intestine. Previous studies provided evidence for a role of ANO1 in mucus secretion. In the present study we investigated
Externí odkaz:
https://doaj.org/article/06c1135f56334127a708313a72426579
Autor:
Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, Ronan Smith, Elena Schneider-Futschik, Nina Eikelis, Piraveen Pirakalathanan, David Parsons, Martin Donnelley
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/725af926fa9c429f9377c586aaa5b7a7
Autor:
Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, Ronan Smith, Elena Schneider-Futschik, Nina Eikelis, Piraveen Pirakalathanan, David Parsons, Martin Donnelley
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction:Phe508del is the most common cystic fibrosis transmembrane conductance regulator (CFTR) gene variant that results in the recessive genetic disorder cystic fibrosis (CF). The recent development of highly effective CFTR modulator therapies
Externí odkaz:
https://doaj.org/article/d6e52064a46e407fbcacadcbcf9524f1
Akademický článek
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Akademický článek
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To bead or not to bead: A review of Pseudomonas aeruginosa lung infection models for cystic fibrosis
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Cystic fibrosis (CF) lung disease is characterised by recurring bacterial infections resulting in inflammation, lung damage and ultimately respiratory failure. Pseudomonas aeruginosa is considered one of the most important lung pathogens in those wit
Externí odkaz:
https://doaj.org/article/969e444d6b584b46a13f2b92e4981943