Zobrazeno 1 - 10
of 402
pro vyhledávání: '"P. Casillo"'
Autor:
Alessandro Ottaiano, Mariachiara Santorsola, Monica Ianniello, Anna Ceccarelli, Marika Casillo, Francesco Sabbatino, Nadia Petrillo, Marco Cascella, Francesco Caraglia, Carmine Picone, Francesco Perri, Roberto Sirica, Silvia Zappavigna, Guglielmo Nasti, Giovanni Savarese, Michele Caraglia
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background TAS-102 (Lonsurf®) is an oral fluoropyrimidine consisting of a combination of trifluridine (a thymidine analog) and tipiracil (a thymidine phosphorylation inhibitor). The drug is effective in metastatic colorectal cancer (mCRC) p
Externí odkaz:
https://doaj.org/article/0cb75c489e0747b7a5a221e4b1270d45
Autor:
Antonietta Monda, Maria Ester La Torre, Antonietta Messina, Girolamo Di Maio, Vincenzo Monda, Fiorenzo Moscatelli, Marida De Stefano, Marco La Marra, Marilena Di Padova, Anna Dipace, Pierpaolo Limone, Maria Casillo, Marcellino Monda, Giovanni Messina, Rita Polito
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The ketogenic diet (KD) is marked by a substantial decrease in carbohydrate intake and an elevated consumption of fats and proteins, leading to a metabolic state referred to as “ketosis,” where fats become the primary source of energy. Recent res
Externí odkaz:
https://doaj.org/article/939532e2c9e641d2a7fc05dda90761db
Autor:
Sergio D’ambrosio, Azza Dabous, Saba Sadiq, Angela Casillo, Chiara Schiraldi, Elisabetta Cassese, Emiliano Bedini, Maria Michela Corsaro, Donatella Cimini
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Introduction:B. animalis subsp. lactis HN019 is a commercially available well-characterized probiotic with documented effects on human health, such as the ability to enhance the immune function and to balance the intestinal microbiome. Therefore, opt
Externí odkaz:
https://doaj.org/article/f7906f863d724447935bb844803e95d8
Publikováno v:
Journal of Biological Research, Vol 77, Iss 1-3 (2024)
The detailed mechanism by which the primary sequence of a protein encodes its tertiary structure, and by which a protein spontaneously acquires its native fold, is still unclear. Myoglobin provides a good versatile system to investigate the factors t
Externí odkaz:
https://doaj.org/article/a0bc1d51bb354ee2ad619a041dc32825
Autor:
M. Smimmo, V. Casale, G.M. Casillo, E. Mitidieri, R. d'Emmanuele di Villa Bianca, I. Bello, A. Schettino, R. Montanaro, V. Brancaleone, C. Indolfi, G. Cirino, A. Di Lorenzo, M. Bucci, E. Panza, V. Vellecco
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116466- (2024)
Here, by using in vitro and ex vivo approaches, we elucidate the impairment of the hydrogen sulfide (H2S) pathway in vascular complications associated with metabolic syndrome (MetS). In the in vitro model simulating hyperlipidemic/hyperglycemic condi
Externí odkaz:
https://doaj.org/article/94e7c7f836464a949e420b8d7de95de1
To provide privacy-aware software systems, it is crucial to consider privacy from the very beginning of the development. However, developers do not have the expertise and the knowledge required to embed the legal and social requirements for data prot
Externí odkaz:
http://arxiv.org/abs/2202.01035
Autor:
Antonietta Monda, Maria Ida de Stefano, Ines Villano, Salvatore Allocca, Maria Casillo, Antonietta Messina, Vincenzo Monda, Fiorenzo Moscatelli, Anna Dipace, Pierpaolo Limone, Girolamo Di Maio, Marco La Marra, Marilena Di Padova, Sergio Chieffi, Giovanni Messina, Marcellino Monda, Rita Polito
Publikováno v:
Foods, Vol 13, Iss 16, p 2627 (2024)
The prevalence of obesity has become a global health concern, with significant impacts on quality of life and mortality rates. Recent research has highlighted the role of ultra-processed foods (UPFs) in driving the obesity epidemic. UPFs undergo exte
Externí odkaz:
https://doaj.org/article/a55ede1e0a7242e08e1d13670976b0c7
Publikováno v:
Marine Drugs, Vol 22, Iss 8, p 363 (2024)
In marine ecosystems, communication among microorganisms is crucial since the distance is significant if considered on a microbial scale. One of the ways to reduce this gap is through the production of extracellular vesicles, which can transport mole
Externí odkaz:
https://doaj.org/article/ffde26df864845cbb819ae8283c8505e
Autor:
Stephanie M. Casillo, Taylor A. Gatesman, Akanksha Chilukuri, Srinidhi Varadharajan, Brenden J. Johnson, Daniel R. David Premkumar, Esther P. Jane, Tritan J. Plute, Robert F. Koncar, Ann-Catherine J. Stanton, Carlos A.O. Biagi-Junior, Callie S. Barber, Matthew E. Halbert, Brian J. Golbourn, Katharine Halligan, Andrea F. Cruz, Neveen M. Mansi, Allison Cheney, Steven J. Mullett, Clinton Van’t Land, Jennifer L. Perez, Max I. Myers, Nishant Agrawal, Joshua J. Michel, Yue-Fang Chang, Olena M. Vaske, Antony MichaelRaj, Frank S. Lieberman, James Felker, Sruti Shiva, Kelsey C. Bertrand, Nduka Amankulor, Costas G. Hadjipanayis, Kalil G. Abdullah, Pascal O. Zinn, Robert M. Friedlander, Taylor J. Abel, Javad Nazarian, Sriram Venneti, Mariella G. Filbin, Stacy L. Gelhaus, Stephen C. Mack, Ian F. Pollack, Sameer Agnihotri
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113557- (2024)
Summary: Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results in aberrantly permissive activation of oncogenic signaling pathways. Previous stu
Externí odkaz:
https://doaj.org/article/a1cfb726d57743518bf0449e2947643f
Autor:
Esther P. Jane, Matthew C. Reslink, Taylor A. Gatesman, Matthew E. Halbert, Tracy A. Miller, Brian J. Golbourn, Stephanie M. Casillo, Steven J. Mullett, Stacy G. Wendell, Udochukwu Obodo, Dinesh Mohanakrishnan, Riya Dange, Antony Michealraj, Charles Brenner, Sameer Agnihotri, Daniel R. Premkumar, Ian F. Pollack
Publikováno v:
Molecular Oncology, Vol 17, Iss 9, Pp 1821-1843 (2023)
In previous studies, we demonstrated that panobinostat, a histone deacetylase inhibitor, and bortezomib, a proteasomal inhibitor, displayed synergistic therapeutic activity against pediatric and adult high‐grade gliomas. Despite the remarkable init
Externí odkaz:
https://doaj.org/article/855c1c665c7544d3830b200c1e512815