Zobrazeno 1 - 10
of 767
pro vyhledávání: '"P. Canoll"'
Autor:
Mao, Lingchao, Wang, Hairong, Hu, Leland S., Tran, Nhan L, Canoll, Peter D, Swanson, Kristin R, Li, Jing
Cancer remains one of the most challenging diseases to treat in the medical field. Machine learning has enabled in-depth analysis of rich multi-omics profiles and medical imaging for cancer diagnosis and prognosis. Despite these advancements, machine
Externí odkaz:
http://arxiv.org/abs/2401.06406
Autor:
Hairong Wang, Michael G. Argenziano, Hyunsoo Yoon, Deborah Boyett, Akshay Save, Petros Petridis, William Savage, Pamela Jackson, Andrea Hawkins-Daarud, Nhan Tran, Leland Hu, Kyle W. Singleton, Lisa Paulson, Osama Al Dalahmah, Jeffrey N. Bruce, Jack Grinband, Kristin R. Swanson, Peter Canoll, Jing Li
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Intratumoral heterogeneity poses a significant challenge to the diagnosis and treatment of recurrent glioblastoma. This study addresses the need for non-invasive approaches to map heterogeneous landscape of histopathological alterations thro
Externí odkaz:
https://doaj.org/article/d5dad2992549480bb73b3faa28c1de97
Autor:
Xu Hua, Hui Zhou, Hui-Chen Wu, Julia Furnari, Corina P. Kotidis, Raul Rabadan, Jeanine M. Genkinger, Jeffrey N. Bruce, Peter Canoll, Regina M. Santella, Zhiguo Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Aberrant DNA methylation patterns have been used for cancer detection. However, DNA hemi-methylation, present at about 10% CpG dinucleotides, has been less well studied. Here we show that a majority of differentially hemi-methylated regions
Externí odkaz:
https://doaj.org/article/50798e554b5e4411b46deb180e2635df
Autor:
Dennis Huang, Angeliki Mela, Natarajan V. Bhanu, Benjamin A. Garcia, Peter Canoll, Patrizia Casaccia
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101042- (2024)
Proneural gliomas are brain tumors characterized by enrichment of oligodendrocyte progenitor cell (OPC) transcripts and genetic alterations. In this study we sought to identify transcriptional and epigenetic differences between OPCs with Trp53 deleti
Externí odkaz:
https://doaj.org/article/6db1d6b7c3b943999a65b9f97ac8f027
Autor:
Natanael Zarco, Athanassios Dovas, Virginea de Araujo Farias, Naveen K.H. Nagaiah, Ashley Haddock, Peter A. Sims, Dolores Hambardzumyan, Christian T. Meyer, Peter Canoll, Steven S. Rosenfeld, Rajappa S. Kenchappa
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111311- (2024)
Summary: While mitotic spindle inhibitors specifically kill proliferating tumor cells without the toxicities of microtubule poisons, resistance has limited their clinical utility. Treating glioblastomas with the spindle inhibitors ispinesib, aliserti
Externí odkaz:
https://doaj.org/article/fff89d0ebc074d0d9a058fe324ae3cb5
Applications of single-cell RNA sequencing in various biomedical research areas have been blooming. This new technology provides unprecedented opportunities to study disease heterogeneity at the cellular level. However, unique characteristics of scRN
Externí odkaz:
http://arxiv.org/abs/2110.12964
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 973 (2024)
Glioblastoma remains a devastating disease with a bleak prognosis despite continued research and numerous clinical trials. Convection-enhanced delivery offers researchers and clinicians a platform to bypass the blood–brain barrier and administer dr
Externí odkaz:
https://doaj.org/article/b94e5f7c13ac4ce7a69df87e089fbd3b
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Alzheimer’s disease (AD) is the most frequent form of dementia. It is characterized by pronounced neuronal degeneration with formation of neurofibrillary tangles and deposition of amyloid β throughout the central nervous system. Animal models have
Externí odkaz:
https://doaj.org/article/916d114859f74b4a88719425c2630917
Autor:
Sun, Haoran, Liu, Xueqing, Feng, Xinyang, Liu, Chen, Zhu, Nanyan, Gjerswold-Selleck, Sabrina J., Wei, Hong-Jian, Upadhyayula, Pavan S., Mela, Angeliki, Wu, Cheng-Chia, Canoll, Peter D., Laine, Andrew F., Vaughan, J. Thomas, Small, Scott A., Guo, Jia
Publikováno v:
The IEEE International Symposium on Biomedical Imaging (ISBI) 2020
Cerebral blood volume (CBV) is a hemodynamic correlate of oxygen metabolism and reflects brain activity and function. High-resolution CBV maps can be generated using the steady-state gadolinium-enhanced MRI technique. Such a technique requires an int
Externí odkaz:
http://arxiv.org/abs/2001.05551
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