Zobrazeno 1 - 10
of 208
pro vyhledávání: '"P. C. Sinha"'
Autor:
Celeste Parra Bravo, Karen Krukowski, Sarah Barker, Chao Wang, Yaqiao Li, Li Fan, Edwin Vázquez-Rosa, Min-Kyoo Shin, Man Ying Wong, Louise D. McCullough, Ryan S. Kitagawa, H. Alex Choi, Angela Cacace, Subhash C. Sinha, Andrew A. Pieper, Susanna Rosi, Xu Chen, Li Gan
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-19 (2024)
Abstract Background Tau is aberrantly acetylated in various neurodegenerative conditions, including Alzheimer’s disease, frontotemporal lobar degeneration (FTLD), and traumatic brain injury (TBI). Previously, we reported that reducing acetylated ta
Externí odkaz:
https://doaj.org/article/3740b616df0e4c68b196af27d37bdb39
Autor:
William J. Netzer, Anjana Sinha, Mondana Ghias, Emily Chang, Katherina Gindinova, Emily Mui, Ji-Seon Seo, Subhash C. Sinha
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
We previously showed that the anticancer drug imatinib mesylate (IMT, trade name: Gleevec) and a chemically distinct compound, DV2-103 (a kinase-inactive derivative of the potent Abl and Src kinase inhibitor, PD173955) lower Aβ levels at low micromo
Externí odkaz:
https://doaj.org/article/8e5f35bf5ec14ed0b3b22c64a5fe5708
Autor:
Tajnin Sultana, David M. Morgan, Beau D. Jernberg, Peyton Zak, Sangita C. Sinha, Christopher L. Colbert
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1108 (2024)
Abstract: Cell surface signaling (CSS) is a means of rapidly adjusting transcription in response to extracellular stimuli in Gram-negative bacteria. The pseudobactin BN7/8 uptake (Pup) system not only imports iron but also upregulates its own transcr
Externí odkaz:
https://doaj.org/article/0951e8fbafff474e99a3e0a51e884266
Autor:
Dionnet L. Bhatti, Junghee Jin, Jia Cheng, Kathryn McCabe, Ko-Woon Lee, Clara Berdasco, Yu Young Jeong, Subhash C. Sinha, Yong Kim
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
The prefrontal cortex (PFC) is a key neural node mediating behavioral responses to stress and the actions of ketamine, a fast-acting antidepressant. The molecular mechanisms underlying these processes, however, are not fully understood. Our recent st
Externí odkaz:
https://doaj.org/article/845b09bf82bf497e8e027498e00a068f
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-17 (2023)
Abstract DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the DNA sensors, cyclic GMP-AMP synthase (cGAS) is a primary player in d
Externí odkaz:
https://doaj.org/article/c19a965ed47e49e6bf3579534077e085
Publikováno v:
Journal of Road Engineering, Vol 3, Iss 3, Pp 239-251 (2023)
The motivation for cost-effective management of highway pavements is evidenced not only by the massive expenditures associated with these activities at a national level but also by the consequences of poor pavement condition on road users. This paper
Externí odkaz:
https://doaj.org/article/44879406cbc84c7c81e6ed1093bf7e00
Autor:
Abena B. Redwood, Xiaomei Zhang, Sahil B. Seth, Zhongqi Ge, Wendy E. Bindeman, Xinhui Zhou, Vidya C. Sinha, Timothy P. Heffernan, Helen Piwnica-Worms
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract The relationship between ATR/Chk1 activity and replication stress, coupled with the development of potent and tolerable inhibitors of this pathway, has led to the clinical exploration of ATR and Chk1 inhibitors (ATRi/Chk1i) as anticancer the
Externí odkaz:
https://doaj.org/article/f52fc4ae77174e23822274182d58cffc
Autor:
Vidya C. Sinha, Amanda L. Rinkenbaugh, Mingchu Xu, Xinhui Zhou, Xiaomei Zhang, Sabrina Jeter-Jones, Jiansu Shao, Yuan Qi, John A. Zebala, Dean Y. Maeda, Florencia McAllister, Helen Piwnica-Worms
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The classification of breast lesions as indolent or aggressive to tailor treatment is crucial. Here, the authors use single-cell transcriptomics and multiparametric imaging of a breast cancer mouse model, report distinct tumor-immune features for the
Externí odkaz:
https://doaj.org/article/edf450673bba4946ad0410cdc2344397
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The anisotropy in resonant tunneling transport through an electrostatic barrier in monolayer black phosphorus either in presence or in absence of an oscillating potential is studied. Non-perturbative Floquet theory is applied to solve the ti
Externí odkaz:
https://doaj.org/article/a11a454f12c84235a73d51685cfdb041
Autor:
Sunil Kumar Singh, Navin Viswakarma, Gautam Sondarva, Rakesh Sathish Nair, Periannan Sethupathi, Matthew Dorman, Subhash C Sinha, Kent Hoskins, Gregory Thatcher, Basabi Rana, Ajay Rana
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The mitogen-activated protein kinases (MAPKs) are important for T cell survival and their effector function. Mixed lineage kinase 3 (MLK3) (MAP3K11) is an upstream regulator of MAP kinases and emerging as a potential candidate for targeted
Externí odkaz:
https://doaj.org/article/a88048066d8f4bf1819a611e152d52ec