Zobrazeno 1 - 10
of 14
pro vyhledávání: '"P. C. Humphries"'
Autor:
Ashley C Humphries, Claudia Molina-Pelayo, Parijat Sil, C Clayton Hazelett, Danelle Devenport, Marek Mlodzik
Publikováno v:
PLoS Genetics, Vol 19, Iss 7, p e1010849 (2023)
Epithelial tissues can be polarized along two axes: in addition to apical-basal polarity they are often also polarized within the plane of the epithelium, known as planar cell polarity (PCP). PCP depends upon the conserved Wnt/Frizzled (Fz) signaling
Externí odkaz:
https://doaj.org/article/e58b5580bc26439bbce8e75a92338bf5
Autor:
Lisa Bashorum, Gerard McCaughey, Owen Evans, Ashley C. Humphries, Richard Perry, Alasdair MacCulloch
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-12 (2022)
Abstract Background Fabry Disease (FD) is a rare X-linked metabolic lysosomal disorder. FD has a broad range of symptoms which vary markedly between patients. The heterogenous nature of the disease makes diagnosis difficult for health care profession
Externí odkaz:
https://doaj.org/article/7a8b89bed0a34dcaaef5e492331700e1
Autor:
Duncan C. Humphries, Richard A. O’Connor, Hazel L. Stewart, Tom M. Quinn, Erin E. Gaughan, Beth Mills, Gareth O.S. Williams, James M. Stone, Keith Finlayson, Martine Chabaud-Riou, Florence Boudet, Kevin Dhaliwal, Vincent Pavot
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPulmonary-resident memory T cells (TRM) and B cells (BRM) orchestrate protective immunity to reinfection with respiratory pathogens. Developing methods for the in situ detection of these populations would benefit both research and clinica
Externí odkaz:
https://doaj.org/article/3f4db45336fc448c8b477921e7dd0a20
Autor:
Duncan C. Humphries, Ross Mills, Cecilia Boz, Brian J. McHugh, Nikhil Hirani, Adriano G. Rossi, Anders Pedersen, Hans T. Schambye, Robert J. Slack, Hakon Leffler, Ulf J. Nilsson, Wei Wang, Tariq Sethi, Alison C. Mackinnon
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Rationale: Galectin-3 (Gal-3) drives fibrosis during chronic lung injury, however, its role in acute lung injury (ALI) remains unknown. Effective pharmacological therapies available for ALI are limited; identifying novel concepts in treatment is esse
Externí odkaz:
https://doaj.org/article/012f04bc0d6f4ad19f571846d1bf801d
Autor:
Thomas H. Craven, Tashfeen Walton, Ahsan R. Akram, Emma Scholefield, Neil McDonald, Adam D.L. Marshall, Duncan C. Humphries, Bethany Mills, Thane A. Campbell, Annya Bruce, Joanne Mair, James W. Dear, David E. Newby, Adam T. Hill, Timothy S. Walsh, Chris Haslett, Kevin Dhaliwal
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neutrophil activation is an integral process to acute inflammation and is associated with adverse clinical sequelae. Identification of neutrophil activation in real time in the lungs of patients may permit biological stratification of patien
Externí odkaz:
https://doaj.org/article/e52c1d397194451fb7aab2ac97bdda7d
Autor:
Siu-Fun Wong, Joseph M. Unger, James L. Wade, Lynne I. Wagner, Mario E. Lacouture, Keisha C. Humphries, Anna Moseley, Kathryn Arnold, Mario R. Velasco, Justin D. Floyd, Benjamin T. Esparaz, Afsaneh Barzi, Heinz-Josef Lenz, Marianna Koczywas, Shaker Dakhil, Gary V. Burton, Michael J. Fisch, N. Lynn Henry, Dawn L. Hershman, Carol M. Moinpour
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 4, Iss 1, Pp 1-12 (2020)
Abstract Background Papulopustular rash is a common class effect of epidermal growth factor receptor inhibitors (EGFRI) that can affect patients’ health-related quality of life and cause disruptions to treatment. SWOG S1013 (NCT01416688) is a multi
Externí odkaz:
https://doaj.org/article/cc8f4d5ab8574139b368be4cd9f29553
Autor:
Duncan C. Humphries, Richard A. O’Connor, Daniel Larocque, Martine Chabaud-Riou, Kevin Dhaliwal, Vincent Pavot
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
There is increasing evidence that lung-resident memory T and B cells play a critical role in protecting against respiratory reinfection. With a unique transcriptional and phenotypic profile, resident memory lymphocytes are maintained in a quiescent s
Externí odkaz:
https://doaj.org/article/50ce235d18f047938dfb786049099ccb
Autor:
Duncan C. Humphries, Ross Mills, Ross Dobie, Neil C. Henderson, Tariq Sethi, Alison C. Mackinnon
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Rationale: Galectin-3 (Gal-3) is an immune regulator and an important driver of fibrosis in chronic lung injury, however, its role in acute lung injury (ALI) remains unknown. Previous work has shown that global deletion of galectin-3 reduces collagen
Externí odkaz:
https://doaj.org/article/514aa246c23f4d81a2d479d419fca3f5
Publikováno v:
eLife, Vol 9 (2020)
Planar cell polarity (PCP) and neural tube defects (NTDs) are linked, with a subset of NTD patients found to harbor mutations in PCP genes, but there is limited data on whether these mutations disrupt PCP signaling in vivo. The core PCP gene Van Gogh
Externí odkaz:
https://doaj.org/article/eaa6d68ace4f472f8ea44b2b97473795
Autor:
Neeta Bala Tannan, Giovanna Collu, Ashley C Humphries, Ekatherina Serysheva, Ursula Weber, Marek Mlodzik
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007153 (2018)
AKAP200 is a Drosophila melanogaster member of the "A Kinase Associated Protein" family of scaffolding proteins, known for their role in the spatial and temporal regulation of Protein Kinase A (PKA) in multiple signaling contexts. Here, we demonstrat
Externí odkaz:
https://doaj.org/article/0aaf061388774320b0ae9a0d79c38fcd