Zobrazeno 1 - 10
of 52
pro vyhledávání: '"P. C. Churchill"'
Autor:
Janette M. Watkins, Julia E. Brunnemer, Kathleen N. Heeter, Andrew M. Medellin, William C. Churchill, Janelle M. Goss, James M. Hobson, Nicole E. Werner, R. Glenn Weaver, Vanessa M. Martinez Kercher, Kyle A. Kercher
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Lack of physical activity is a concern for children across diverse backgrounds, particularly affecting those in rural areas who face distinct challenges compared to their urban counterparts. Community-derived interventions are nee
Externí odkaz:
https://doaj.org/article/8ca2ad00805b4cfcad714926e463ded5
Autor:
Caroline C. Churchill, Cristina D. Peterson, Kelley F. Kitto, Kelsey R. Pflepsen, Lalitha R. Belur, R. Scott McIvor, Lucy Vulchanova, George L. Wilcox, Carolyn A. Fairbanks
Publikováno v:
Frontiers in Pain Research, Vol 4 (2024)
Agmatine, a decarboxylated form of L-arginine, prevents opioid analgesic tolerance, dependence, and self-administration when given by both central and systemic routes of administration. Endogenous agmatine has been previously detected in the central
Externí odkaz:
https://doaj.org/article/52efa26146094fbbb8d8e7459e96d505
Autor:
Michael Strupp, Grant C. Churchill, Ivonne Naumann, Ulrich Mansmann, Amani Al Tawil, Anastasia Golentsova, Nicolina Goldschagg
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundBetahistine was registered in Europe in the 1970s and approved in more than 80 countries as a first-line treatment for Menière's disease. It has been administered to more than 150 million patients. However, according to a Cochrane systemat
Externí odkaz:
https://doaj.org/article/461639fe2ac04f599647a45524256226
Publikováno v:
Journal of King Saud University: Science, Vol 35, Iss 7, Pp 102817- (2023)
Date palm “Phoenix dactylifera” variety Zahidi is a unique well-known cultivar. Mature fruits are semi-dry, medium size, cylindrically shaped and golden brown. However, there are three stages to harvesting the dates soft, hard or semi-soft. In th
Externí odkaz:
https://doaj.org/article/91ef7bf4216c4d34aca8f4634c51ef5b
Autor:
Belén Fernández, Pablo Olmedo, Fernando Gil, Elena Fdez, Yahaira Naaldijk, Pilar Rivero-Ríos, Franz Bracher, Christian Grimm, Grant C. Churchill, Sabine Hilfiker
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-11 (2022)
Abstract Increased brain iron content has been consistently reported in sporadic Parkinson’s disease (PD) patients, and an increase in cytosolic free iron is known to cause oxidative stress and cell death. However, whether iron also accumulates in
Externí odkaz:
https://doaj.org/article/db30149298db4ba5a54b6218b3d20ab2
Autor:
Grant C. Churchill, Michael Strupp, Cailley Factor, Tatiana Bremova-Ertl, Mallory Factor, Marc C. Patterson, Frances M. Platt, Antony Galione
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Small changes to molecules can have profound effects on their pharmacological activity as exemplified by the addition of the two-carbon acetyl group to make drugs more effective by enhancing their pharmacokinetic or pharmacodynamic propertie
Externí odkaz:
https://doaj.org/article/8ec79fdb99cd4403ad6f39300b2c4f15
Autor:
Aarti Jagannath, Norbert Varga, Robert Dallmann, Gianpaolo Rando, Pauline Gosselin, Farid Ebrahimjee, Lewis Taylor, Dragos Mosneagu, Jakub Stefaniak, Steven Walsh, Teele Palumaa, Simona Di Pretoro, Harshmeena Sanghani, Zeinab Wakaf, Grant C. Churchill, Antony Galione, Stuart N. Peirson, Detlev Boison, Steven A. Brown, Russell G. Foster, Sridhar R. Vasudevan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms are unclear. Here, the authors show that adenosine A1/A2A receptor antagonists, such as caffeine, shift circadian rhythms and enhance the effects of light,
Externí odkaz:
https://doaj.org/article/fe29a732cf334692a98923abc1d068d8
Autor:
T. Fields, M. Patterson, T. Bremova-Ertl, G. Belcher, I. Billington, G. C. Churchill, W. Davis, W. Evans, S. Flint, A. Galione, U. Granzer, J. Greenfield, R. Karl, R. Kay, D. Lewi, T. Mathieson, T. Meyer, D. Pangonis, F. M. Platt, L. Tsang, C. Verburg, M. Factor, M. Strupp
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background The lack of approved treatments for the majority of rare diseases is reflective of the unique challenges of orphan drug development. Novel methodologies, including new functionally relevant endpoints, are needed to render the deve
Externí odkaz:
https://doaj.org/article/7e79df41cea1412ebe6936c900bbe966
Autor:
Amber C. Churchill, Haiyang Zhang, Kathryn J. Fuller, Burhan Amiji, Ian C. Anderson, Craig V. M. Barton, Yolima Carrillo, Karen L. M. Catunda, Manjunatha H. Chandregowda, Chioma Igwenagu, Vinod Jacob, Gil Won Kim, Catriona A. Macdonald, Belinda E. Medlyn, Ben D. Moore, Elise Pendall, Jonathan M. Plett, Alison K. Post, Jeff R. Powell, David T. Tissue, Mark G. Tjoelker, Sally A. Power
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Shifts in the timing, intensity and/or frequency of climate extremes, such as severe drought and heatwaves, can generate sustained shifts in ecosystem function with important ecological and economic impacts for rangelands and managed pastures. The Pa
Externí odkaz:
https://doaj.org/article/3d0ccb4caccd4964b328afcd3f96ceaf
Autor:
Oscar C. W. Chen, Alexandria Colaco, Lianne C. Davis, Fedir N. Kiskin, Nicole Y. Farhat, Anneliese O. Speak, David A. Smith, Lauren Morris, Emily Eden, Patricia Tynan, Grant C. Churchill, Antony Galione, Forbes D. Porter, Frances M. Platt
Publikováno v:
JIMD Reports, Vol 56, Iss 1, Pp 46-57 (2020)
Abstract Niemann‐Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder caused by mutations in either NPC1 (95% of cases) or NPC2. Reduced late endosome/lysosome calcium (Ca2+) levels and the accumulation of unesterified choles
Externí odkaz:
https://doaj.org/article/0e1a6412d2a14de1a7841b940a26ea33